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Highly exposed to phthalates as fetuses, female mice have altered reproductive lives
Date:3/16/2012

pertain to reproductive hormone receptors.

The story the evidence from the paper seems to tell is that a high level of in utero exposure to MEHP causes female mice to have a shortened but more intense reproductive life, possibly because greater hormone levels induce an elevated number of follicles to release more eggs per estrus cycle. Their lifetime egg supply is therefore used up sooner and along the way their mammary glands end up significantly altered.

A question that Hixon said she'd now like to ask is whether doses of phthalates, combined with a known carcinogen, might result in something closer to cancer in exposed mice. For people and animals outside the lab, encountering low doses of a combination of such potentially harmful chemicals would be a more realistic exposure scenario.

"We don't live in a bubble," Hixon said.


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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

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