Navigation Links
Higher calcium intake may reduce body fat, mitigating genetic risk for diabetes
Date:4/29/2014

SAN DIEGO (April 29, 2014) As the number of people with type 2 diabetes continues to rise and its toll increases, scientists are scrambling to unravel the complex genetic and lifestyle factors behind the disease. A new study finds that African American children with a genetic predisposition to diabetes may be able to reduce their risk by getting the USDA-recommended dose of calcium.

"Even though life expectancy for people with diabetes has gone up, the disease has a significant impact on quality of life, so finding ways to prevent people from developing diabetes is critical," said Laura Tosi, M.D., director of the bone health program at Children's National Medical Center and one of the study's lead investigators. "We were excited to find that higher calcium intake appears to mitigate the impact of some of the risk genes for type 2 diabetes, and we're eager to see if these results hold true in other populations."

An estimated 25 million people in the United States have diabetes, or about 1 in 12 people. African Americans are at especially high risk, and the trajectory for the disease is often set in childhood.

The researchers analyzed DNA samples, detailed nutrition information, body mass index and other health indicators in 142 African American children age 5-9. None of the study participants were diabetic, although 40 percent were overweight and 20 percent were obese.

Among children who tested positive for gene variants known to be associated with type 2 diabetes, those who consumed higher amounts of calcium had a significantly lower body mass index and percent body fat than those with lower calcium intake. Body mass index and percent body fat are strong indicators of a child's risk for developing diabetes later in life.

The USDA recommends children age 4-8 get 1,000 milligrams of calcium per day, the equivalent of about 3.5 8-ounce glasses of milk or 4.5 ounces of cheese. Children age 9-13 years should get about 1,300 milligrams. In addition to dairy products, other calcium-rich foods include tofu, sardines, salmon and some green vegetables.

The study underscores the work of previous researchers, who have shown that many African American children do not get the recommended levels of calcium in their diet. "Twenty percent of participating children consumed no milk in their diet whatsoever and 55 percent consumed less than one serving of milk per day. Only one-quarter of the children met the USDA standard," said Tosi.

Co-investigator Joseph Devaney, Ph.D., said the study could help lead to a more personalized approach to diabetes prevention. "The ultimate goal would be to be able to predict, from a child's genotype, his or her specific risk factors for developing type 2 diabetes, and then develop a targeted preventative approach to mitigate those risk factors with specific lifestyle interventions such as increasing calcium intake or physical activity, for example," said Devaney, director of DNA technologies at Children's National Medical Center.

Although the researchers do not know the exact reason for the association, they speculate that calcium or related dietary factors may cause epigenetic changes that affect how the diabetes-linked genes are expressed.

"What got us interested in this is the whole question of how the environmentincluding a person's dietinfluences gene expression," said Tosi. Although scientists have intensely studied the impact of environmental factors during prenatal development and early infancy, few researchers have examined the impact of such factors later in childhood.

Understanding the interactions of genes and environmental factors in children is especially helpful for a disease as complex as diabetes, said Devaney. By the time an adult is diagnosed with diabetes, there are usually numerous risk factors that need to be addressed. "The earlier you can identify a person's risk factors, the better the opportunity to prevent, or at least delay, full-blown disease," said Devaney.


'/>"/>

Contact: Nancy Lamontagne
media@faseb.org
919-617-1330
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. Obese patients face higher radiation exposure from CT scans -- but new technology can help
2. Higher risk of birth defects from assisted reproduction
3. Higher pain tolerance in athletes may hold clues for pain management
4. Levels of hepatitis C virus higher among African-Americans and males
5. Infants exposed to specific molds have higher asthma risk
6. Risk of developing diabetes higher in neighborhoods that arent walk-friendly: Study
7. Higher-math skills entwined with lower-order magnitude sense
8. How the protein transport machinery in the chloroplasts of higher plants developed
9. Being overweight linked to higher risk of gum disease
10. Kids consumption of sugared beverages linked to higher caloric intake of food
11. Co-Q10 deficiency may relate to concern with statin drugs, higher risk of diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
(Date:3/21/2016)... , March 22, 2016 ... with passcodes for superior security   ... leading provider of secure digital communications services, today announced ... technology and offer enterprise customers, particularly those in the ... recognition and voice authentication within a mobile app, alongside, ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... and READING, England , ... Indegene ( http://www.indegene.com ), ein führender Anbieter ... die Life-Science-Branche, Pharmaunternehmen und Gesundheitsorganisationen, und TranScrip ... von innovativen wissenschaftlichen Support-Services für den gesamten ... IntraScience heute den Ausbau ihrer bestehenden Allianz ...
(Date:5/26/2016)... Despite the volatility that continues to ... Today,s pre-market research on ActiveWallSt.com directs the investor community,s focus ... RDUS ), Cerus Corp. (NASDAQ: CERS ), ... Prime Therapeutics Inc. (NASDAQ: FPRX ). Register with ... http://www.activewallst.com/ On Wednesday, shares in ...
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s Board of Investment’s New ... San Francisco. Located at booth number 7301, representatives from the Thai Government, research ... the Thai biotechnology and life sciences sector. , Deputy Secretary General of ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on the ... Charles W. Stellar has been named by the WEDI Board of Directors as WEDI’s ... an executive leader with more than 35 years of experience in healthcare, association management ...
Breaking Biology Technology: