Navigation Links
High-throughput screen finds compounds that regulate cancer cell invasion
Date:7/26/2011

LA JOLLA, Calif., July 25, 2011 Metastasisthe spread of cancer from the place where it first started to another place in the bodyis the most common reason that cancer treatments fail. To metastasize, some types of cancer cells rely on invadopodia, cellular membrane projections that act like feet, helping them "walk" away from the primary tumor and invade surrounding tissues. To determine how cells control invadopodia formation, scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) screened a collection of pharmacologically active compounds to identify those that either promote or inhibit the process. The study, led by Sara Courtneidge, Ph.D. and postdoctoral researcher Manuela Quintavalle, Ph.D. in collaboration with scientists in Sanford-Burnham's Conrad Prebys Center for Chemical Genomics (Prebys Center), revealed compounds that inhibit invadopodia formation without causing toxicity. The search also turned up several other compounds that increased the number of invadopodia.

Two major findings came out of this research. First, several of the newly identified invadopodia inhibitors targeted a family of enzymes called cyclin-dependent kinases (Cdks), revealing a previously unrecognized role for Cdks in invadopodia formation. Secondly, one of the pro-invadopodia compounds was the chemotherapeutic agent paclitaxela finding that might have implications for the drug's current use in treating cancer. These findings will appear online July 26 in Science Signaling.

"Previous studies by our group and others have demonstrated that we might be able to target invadopodia to prevent cancer cell invasiveness," said Dr. Courtneidge, professor and director of the Tumor Microenvironment Program in Sanford-Burnham's NCI-Designated Cancer Center. "In this study, we established a cell-based screening assay to help us identify regulators of invadopodia formation."

Dr. Courtneidge's group has been studying invadopodia for
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Microfluidic device rapidly orients hundreds of embryos for high-throughput experiments
2. High-throughput analysis of gene regulation, DNA synthesis in Cold Spring Harbor Protocols
3. High-throughput genotyping, protein purification featured in Cold Spring Harbor Protocols
4. New high-throughput screening technique makes probing puzzling proteins possible
5. NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
6. Agilent Technologies and A*STAR launch all-in-one drug screening platform
7. Strides in identifying and improving screening practices and treatment for liver diseases
8. Racial disparities still exist in colorectal cancer screening despite increased Medicare coverage
9. Screening very preterm infants for autism at 18 months often inaccurate
10. 5-minute screen identifies subtle signs of autism in 1-year olds
11. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High-throughput screen finds compounds that regulate cancer cell invasion
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, featuring FPC,s ... in 2015 that relate to sales of FPC1025 for this smartphone ... MSEK for 2015. Jörgen Lantto, CEO of FPC, comments: ... China and we are proud that ... Axon , its first smartphone ...
(Date:7/20/2015)... 2015  Acuity Market Intelligence,s latest research "The ... Commerce and Privacy" forecasts that between 2014 and ... be downloaded to smart mobile devices by 2.2 ... is projected to generate more than $67.9 billion ... forecast period.    "Biometrics is at ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2
... Current standards for classifying foods as "whole grain" are ... new study by Harvard School of Public Health (HSPH) ... the Whole Grain Stamp, actually identified grain products that ... without the Stamp. The researchers urge adoption of a ...
... hybrid fish in his time as a graduate student in ... helped him create one of the most comprehensive snapshots of ... in evolutionary biology. "We can see a surprisingly complex ... species," said Martin, who with Professor Peter Wainwright published a ...
... scientist with Texas A&M AgriLife Research has begun work on ... lipid which can then be used to make more fuel. ... the U.S. Department of Energy, could help solve the challenge ... Yuan of College Station, AgriLife Research plant pathologist and lead ...
Cached Biology News:Foods identified as 'whole grain' not always healthy 2Foods identified as 'whole grain' not always healthy 3A snapshot of pupfish evolution in action 2AgriLife Research gets grant to crack biofuel production waste issue 2
(Date:7/30/2015)... , July 30, 2015   Aratana ... pet therapeutics company focused on the licensing, development ... animals, today announced that its strategic partner VetStem ... dose confirmation study of AT-016, an adipose-derived allogeneic ... the treatment of osteoarthritis pain in dogs. ...
(Date:7/30/2015)... 2015  With over 60,000 customers across the globe, ISN improves the efficiency and ... with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers ... Headquartered in Dallas, TX , ISN has ...
(Date:7/30/2015)... LOUIS, July 30, 2015 HIGHLIGHTS:Q2 ... in 2014) , Reported sales were $697 million ... 2014.  Sales grew organically by 8%, and changes in ... acquisitions increased sales by 1%. , By business ... in Applied and 11% in SAFC Commercial. , ...
(Date:7/30/2015)... ... ... part of its 2015 growth plan and as a follow up to the recently announced ... Laboratories is pleased to announce that it has begun construction on a new Microbiological Laboratory. ... be strictly dedicated to basic USP 51, USP 61, and USP 62 testing specific to ...
Breaking Biology Technology:Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... Nanogea Adds Drs. ... ... Nanogea, a nano-biotech company focused on commercializing the industry,s most sensitive single molecular detection platform, ... have joined its scientific advisory board. , , ,Dr. Caskey is a prominent medical geneticist ...
... Oct. 8 /PRNewswire-FirstCall/ - Medicago Inc. (TSX-V: MDG), ... and affordable vaccines based on proprietary manufacturing technologies ... has been awarded a proof of concept contract ... Command laboratory specifically the Edgewood Chemical Biological Center ...
... ... work based on data collected at the U.S. Department of Energy,s (DOE) Argonne National Laboratory. ... Argonne, Ill. (Vocus) ... award-winning work based on data collected at the U.S. Department of Energy,s (DOE) Argonne National ...
Cached Biology Technology:Nanogea Announces New Scientific Advisory Board Members 2Nanogea Announces New Scientific Advisory Board Members 3Medicago awarded contract by the U.S. Army to explore applications of its plant-based technology in renewable energy 2Argonne's Advanced Photon Source Lit the Way to Chemistry Nobel 2Argonne's Advanced Photon Source Lit the Way to Chemistry Nobel 3
Rabbit polyclonal to NIRF ( Abpromise for all tested applications). Antigen: Synthetic peptide derived from residues 186-235 of human NIRF. Entrez Gene ID: 115426 Swiss Protein ID: Q96PU...
...
...
...
Biology Products: