Navigation Links
High-strain tendons repair less frequently
Date:5/25/2010

In a discovery that seems counterintuitive, a study appearing in the May 21st Journal of Biological Chemistry has found that tendons in high-stress and strain areas, like the Achilles tendon, actually repair themselves less frequently than low-stress tendons. This study sheds some light on the increased susceptibility of certain tendons to injury during aging.

Tendons, composed of collagen and other proteins, serve to connect muscle to bone and thus are vital for movement. Considering their strenuous activity, tendons need to be continually repairing collagen damage to avoid buildup of degraded proteins that could cause serious complications. Not all tendons are equal though; some tendons, like those in the hand, are primarily used to maintain proper limb placement while others, like the Achilles tendon in humans and the superficial digital flexor tendon (SDFT) in horses, have to bear a lot of weight and strain.

It would be expected that high-strain tendons would repair more frequently, yet Dr Helen Birch at University College London and colleagues examined protein turnover in the tendons of horses of various ages and found that the high-strain SDFT (located at the rear of the limb) repairs much less frequently than the low-strain common digital extensor tendon (CDET, located at the front of the limb). Birch and colleagues used an approach called amino acid racemization to measure protein age in the horse tendons. Amino acids are always incorporated into proteins in a specific orientation called the L-form, but afterwards can spontaneously convert into a mirror image called the D-form. Therefore, by measuring the ratio of L and D amino acids over time, one can estimate the half-life of a protein.

Through this method, the researchers found that non-collagen proteins in tendon have an average half life of 2.2 years in SDFT and 3.5 years in CDET, which would be expected. However, SDFT collagen had a half-life of 198 years, comp
'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Engineers create bone that blends into tendons
2. Human derived stem cells can repair rat hearts damaged by heart attack
3. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
4. Enzyme alerts cells powerful army to repair DNA damage
5. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
6. Simulation reveals how body repairs balance after damage
7. Using nanotubes to detect and repair cracks in aircraft wings, other structures
8. Enhanced DNA-repair mechanism can cause breast cancer
9. Yale receives $8.4 million to study DNA repair in cancer cells
10. Building the future -- 21st century nano tools to repair the nervous system
11. Researchers probe a DNA repair enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... manufacturers in China . The order value ... of + 1 000 MSEK for 2015.   Jörgen ...
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a ... established helmet producer, announced today that they will expand ... the world,s first bio-sensing cycling helmet and the first ... in two new colors in order to give cyclists ... product. In addition, LifeBEAM and Lazer announced their plan ...
(Date:4/27/2015)... , Apr. 27, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... shipping to pre-order customers the first week of May, ... the month of May. Gino ... significant milestone for the company as Wocket® enters the ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3
... before. Whether it,s the death of a physically fit high school ... woman gardening in the middle of the day in July, heat ... treatment beyond submersion in ice water or the application of ice ... But, in a new study published today in the journal ...
... The decade from 2000 to 2009 was the warmest ... studies have shown evidence of changes in mountain plant ... yet taken a continental-scale view of the situation ... of mountain vegetation to climate change," scheduled for Advance ...
... this month, Biology of Reproduction is shifting its ... in Press production will remain unchanged for the time ... www.biolreprod.org as they are completed, rather than being ... the versions of record. At the end of each month, ...
Cached Biology News:'Couch potato pill' might stop heat stroke too 2'Couch potato pill' might stop heat stroke too 3European mountain vegetation shows effects of warmer climate 2
(Date:6/2/2015)... 2, 2015   Intrexon Corporation (NYSE: ... announced today the appointment of Olivier R. ... Sector.  Mr. Jarry will lead the expansion of ... applications for consumer markets.  Mr. ... experience in leading global life sciences and consumer ...
(Date:6/2/2015)... Cord Blood Corporation (NYSE: CO ) ("CCBC," the "Company," ... provider of cord blood collection, laboratory testing, hematopoietic stem cell ... Special Committee of the Company,s board of directors (the "Special ... ) Limited as its independent financial advisor, Cleary ... United States legal counsel and Maples & Calder ...
(Date:6/2/2015)... AZ (PRWEB) June 02, 2015 Through ... microscope technology, Yancy Corporation is enabling World ... desired material and biological sample, displaying the full nature ... bonds between atoms. , Jeff Porter, Co-Founder of the ... are just that – rare. They come once in ...
(Date:6/2/2015)... Orleans, LA (PRWEB) June 02, 2015 ... custom gene synthesis to improve protein expression, announced the ... board includes six executives and entrepreneurs with a broad ... software industries. , The team includes: , Jimmy ... Fund: , Roussel has a background in technology and ...
Breaking Biology Technology:Intrexon Announces New Sector Leader 2Intrexon Announces New Sector Leader 3China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 2China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 3Scientists Eying Rare Discovery Of New Physics & Light Microscope Technology 2GenoCAD Announces New Board of Advisors, Improves Protein Expression Using Custom Gene Synthesis 2GenoCAD Announces New Board of Advisors, Improves Protein Expression Using Custom Gene Synthesis 3
... to coordinate 700 patient trial of EGFR targeting, ... and neck cancer,MISSISSAUGA, ON, Jan. 5 /PRNewswire-FirstCall/ - ... an oncology company that identifies, develops and commercializes ... the National Cancer Centre of Singapore (NCCS) has ...
... Officials of the West Penn Allegheny,Health System and ... recognized burn surgeons Larry M. Jones, MD, FACS,and Roger ... Burn Center. , Drs. Jones ... one of the,country,s preeminent programs for the treatment of ...
... NEWNAN, Ga., Dec. 31 Against the backdrop ... is a biotechnology firm in,suburban Atlanta with a ... Only,days after receiving FDA approval to market the ... tumors (tumors with a large number of blood ...
Cached Biology Technology:YM BIOSCIENCES' NIMOTUZUMAB SELECTED FOR MULTINATIONAL PHASE III TRIAL BY NATIONAL CANCER CENTRE OF SINGAPORE 2YM BIOSCIENCES' NIMOTUZUMAB SELECTED FOR MULTINATIONAL PHASE III TRIAL BY NATIONAL CANCER CENTRE OF SINGAPORE 3YM BIOSCIENCES' NIMOTUZUMAB SELECTED FOR MULTINATIONAL PHASE III TRIAL BY NATIONAL CANCER CENTRE OF SINGAPORE 4West Penn Allegheny Health System Announces Recruitment of Leading Burn Specialists 2West Penn Allegheny Health System Announces Recruitment of Leading Burn Specialists 3First U.S. Implants of Newly Approved Embozene(TM) Color-Advanced Microspheres Embolization Platform 2First U.S. Implants of Newly Approved Embozene(TM) Color-Advanced Microspheres Embolization Platform 3First U.S. Implants of Newly Approved Embozene(TM) Color-Advanced Microspheres Embolization Platform 4
Anti-human C3a/C3a des-Arg (neo-epitope), Clone 2991, Monoclonal Antibody...
Phospho-FADD (Ser194) Antibody (Human Specific)...
... polyclonal to FANCM ( Abpromise for ... Synthetic peptide derived from within residues ... (Note: the amino acid sequence is ... ab27787 .) Entrez ...
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Biology Products: