Navigation Links
High-res view of zinc transport protein
Date:9/13/2009

solution of their x-ray vision by a mere angstrom (tenth of a nanometer). But because it brought the overall resolution of their structure to just below 3 angstroms the point at which individual atoms begin to become visible it enabled the scientists to see the protein in action as it bound to and transported zinc ions.

Using fluorescent probes, the scientists also studied how the protein changed shape in response to zinc binding. And they tested how changes to structural elements of the zinc transporter protein would affect its ability to transport zinc.

Together, these experiments suggest an auto-regulatory mechanism for zinc transport: Zinc binding within the cell triggers hinge-like movements of two electrically repulsive portions of the protein that lie within the cell's interior, which results in a conformational change in the portion of the protein that traverses the cellular membrane. So when zinc levels inside the cell rise too high, this shape shifting somehow pushes zinc ions through the membrane and out of the cell.

"Exactly how the protein pushes the zinc ions through the membrane has yet to be determined," said Fu, who added that this will be a focus of future research.

Conceivably, he added, drugs that bind to the zinc-sensing portions of the protein could be used to modulate zinc transport activity and help adjust zinc levels as possible treatments for diseases such as seizure disorders or diabetes. Brookhaven Science Associates, which manages Brookhaven Lab, has filed a patent application related to this work.

In addition, because other metal transporting proteins share similar architecture with the zinc transporter protein, the findings from this study may advance the understanding of other medical disorders linked to metal imbalance, as well as the development of possible treatments for those conditions.

Furthermore, this work may have implications for researchers trying to improve the prospe
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First high-res 3D structures of mammalian HSP90 protein solved
2. Book is the first high-resolution digital mouse brain atlas designed for Web applications
3. Mechanism for the in-vivo transport of siRNA
4. Conference on sustainable transportation is Oct. 29-31
5. Contribution of cholesterol transporter to vascular disease
6. Cornell researchers prove how plants transport sugars
7. Floating a big idea: MIT demos ancient use of rafts to transport goods
8. Montana State University researchers map iron transport protein
9. Livermore researchers use carbon nanotubes for molecular transport
10. UCLA researchers clarify function of glucose transport molecule
11. Protein transports nutrients believed to protect against eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ...  report to their offering. One ... in technology. With continuous advances in technology, it ... latest standard that meets the needs and expectations ...
(Date:12/10/2014)... 9, 2014  Valencell, a leader in performance biometric ... staggering demand from its licensees for highly accurate, clinically ... not solely coming from fitness and health sectors, but ... "A wearable is only as useful as the biometric ... ultimate driver in long-term mass consumer adoption of wearable ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... inside the nuptial gift that a potential suitor brings to ... the whole package, white silk wrappings and all, that can ... Mariana Trillo, Valentina Melo-Gonzlez and Mara Jos Albo of the ... out the first study to look at the role of ...
... matter microstructure, the communication pathways of the brain, continues ... in white matter microstructure to specific cognitive abilities in ... not include individuals from the entire life span or ... knowledge gap prompted a new study published this week ...
... Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) is pleased ... AIDS treatment and prevention programs in six districts ... for International Development (USAID) and the U.S. President,s ... services offered through EGPAF,s Strengthening Clinical Services (SCS) ...
Cached Biology News:White silk wrappings key to female spider's heart 2Your brain is fine-tuning its wiring throughout your life 2Lesotho takes new steps toward HIV/AIDS elimination 2
(Date:12/19/2014)... Charm Sciences is pleased to announce that ... Aflatoxin M1 in raw commingled milk is the first ... The peer reviewed report of the validation by Technology ... and Fisheries Research (ILVO-T&V) has been published by the ... most toxic aflatoxin and a known carcinogen, can be ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. ... announced today that they have been acquired by Roche ... is a privately held company that provides a big ... generation sequencing (NGS) data for the academic and translational ... Sequencing Unit, and will continue to focus on development ...
(Date:12/19/2014)... December 18, 2014 Today, ... its pilot production facility and future company headquarters ... produce innovative new materials that safely and effectively ... only because of its historic, strong support for ... to attract leading edge, technology-based companies such as ...
(Date:12/19/2014)... iLab Solutions, the global leader in ... Bryant as the new Director of Institutional Implementations and ... These two new leadership positions were created to support ... that iLab continues to meet the needs of its ... iLab has been deployed at over 450 core facilities ...
Breaking Biology Technology:Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2
... Ga., Jan. 10, 2012  MiMedx Group, Inc. (OTCBB: ... patent protected regenerative biomaterials and bioimplants processed from ... received the certification for the Company,s proprietary CollaFix™ ... Mesh CD, which is a Class III product ...
... 10, 2012 iBio, Inc. (NYSE AMEX: IBIO) announced ... units at $0.65 per unit for gross proceeds of approximately ... stock and 0.75 of a warrant to purchase one share ... of $0.88 per share, will be exercisable beginning one year ...
... BOTHELL, Wash., Jan. 10, 2012   BioLife Solutions Inc. ... hypothermic storage and cryopreservation freeze media ... the fourth quarter and full calendar year 2011. Highlights include: ... Preliminary fourth quarter revenue of $809,000, up 13% over the ...
Cached Biology Technology:MiMedx Group, Inc. Receives CE Certification for Its CollaFix™ Surgical Mesh CD 2iBio, Inc. Prices $10 Million Public Offering 2iBio, Inc. Prices $10 Million Public Offering 3iBio, Inc. Prices $10 Million Public Offering 4BioLife Solutions 2011 Revenue Up 33% 2BioLife Solutions 2011 Revenue Up 33% 3
Any form, any size, any number of mutageneses. ExonBio provides the best service with double sequecing to make sure the success of the mutagenesis....
Loading Buffer...
Request Info...
Request Info...
Biology Products: