Navigation Links
High-res view of zinc transport protein
Date:9/13/2009

UPTON, NY How much difference can a tenth of a nanometer make? When it comes to figuring out how proteins work, an improvement in resolution of that miniscule amount can mean the difference between seeing where atoms are and understanding how they interact.

Case in point: New, improved-resolution views of a zinc transporter protein deciphered at the U.S. Department of Energy's Brookhaven National Laboratory provide not just a structure but also a suggested mechanism for how cells sense and regulate zinc, an element that is essential for life, but which must be kept at a steady state to avoid problems like seizures, diabetes, and possibly Alzheimer's disease.

The new findings, to be published online on September 13, 2009, by Nature Structural & Molecular Biology, also suggest targets for zinc-regulating drugs, and may even advance the understanding of similar zinc-regulating enzymes in plant chloroplasts with possible implications for biofuel production.

"Our goal is to reveal atomic interactions in a protein structure to understand the chemistry that underlies the protein's biological function," said Brookhaven biologist Dax Fu, who led the research. "With this structure, we can begin to understand the mechanism of zinc transport at a chemical level."

The structure was revealed using x-ray crystallography at Brookhaven Lab's [http://www.nsls.bnl.gov/] National Synchrotron Light Source (NSLS), a source of intense x-ray, ultraviolet, and infrared light. By studying how x-rays bounce off crystallized samples of a protein, scientists can reconstruct the location and orientation of the protein's atoms in three dimensions.

The Brookhaven team had previously used NSLS to solve a zinc transporter protein structure at lower resolution*. To achieve the new-and-improved structure, the scientists added mercury atoms to stabilize protein packing in the crystals. This increased the re
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First high-res 3D structures of mammalian HSP90 protein solved
2. Book is the first high-resolution digital mouse brain atlas designed for Web applications
3. Mechanism for the in-vivo transport of siRNA
4. Conference on sustainable transportation is Oct. 29-31
5. Contribution of cholesterol transporter to vascular disease
6. Cornell researchers prove how plants transport sugars
7. Floating a big idea: MIT demos ancient use of rafts to transport goods
8. Montana State University researchers map iron transport protein
9. Livermore researchers use carbon nanotubes for molecular transport
10. UCLA researchers clarify function of glucose transport molecule
11. Protein transports nutrients believed to protect against eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... Germany , June 17, 2015 ... Standard: QIA) today launched new Investigator ® STR assay ... the United States . The new genetic ... key genomic markers (short tandem repeats or STRs) for DNA ... evaluate the quality of DNA in each sample, a novel ...
(Date:6/17/2015)... Fla. , June 17, 2015  Crossmatch™, ... today announced that its U.are.U ® 4500 ... Togo,s Eateries, Inc., a ... sandwich chain, to increase security, improve accountability and ... readers enable instant, non-repudiable identity confirmation for employee ...
(Date:6/16/2015)... , June 16, 2015  With the increasing number ... remains a top concern. The recent compromise of ... need for strong authentication within government agencies. ... biometric one-time password (OTP) authenticator, has been submitted for ... 140-2 Level 3 validation for tamper proofing. ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... 2011, Cleveland: Researchers have identified a genetic mutation found ... a fatal developmental disease in fetuses and infants, according ... of Science . The genetic mutation is ... causing microcephalic osteodysplastic primoridal dwarfism type 1 (MOPD1), a ...
... using biofuels for gasoline. About a quarter of their ... carbon dioxide emissions that otherwise would be emitted from ... of Global Ecology have found that sugarcane has a ... occupied by other Brazilian crops cools the local climate. ...
... annual Nutrition & The Eye conference, April 16-17, hosted by ... St. Louis, says molecular medicine is beginning to provide hope ... been exhausted. "These nutritional molecules have begun to be ... and some human studies", Dr Richer reported. Dr. Richer ...
Cached Biology News:Genetic mutation linked to lethal disease 2Sugarcane cools climate 2Low-cost molecular medicine should be included in modern eye physicians' tool kit 2
(Date:7/6/2015)... 6, 2015  Approximately 1% of the population inherits ... chromosomes. These individuals are three times more likely to ... one of the nation,s leading medical journals by researchers ... Photo - http://photos.prnewswire.com/prnh/20150706/230685 ... causes roseola (also known as "sixth disease") and occasional ...
(Date:7/6/2015)... ... 06, 2015 , ... Discovery of new biomarkers for patient ... of the global molecular diagnostics market. BCC Research reveals in its new report ... diagnostic tests will increase demand for inexpensive and accurate tests for genetic compatibility ...
(Date:7/6/2015)... July 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), a ... Scheller , Viveve,s Chief Executive Officer, and Scott Durbin ... on July 9, 2015. , , , DATE:    ... , , , TIME:     , , , 12:15 ... , , http://tinyurl.com/viveve   , ...
(Date:7/6/2015)... , July 6, 2015 ImmunoCellular Therapeutics, ... of an agreement with Novella Clinical (Novella), ... in patients with newly diagnosed glioblastoma. Novella is a ... services to small to mid-sized oncology companies. The ICT-107 ... in the US, Europe and ...
Breaking Biology Technology:Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2
... SUMMIT and TOKYO, February 4 Bluegiga,announced today ... with,Bluetooth Health Device Profile (HDP). The Health Device ... the Bluegiga,module, significantly simplifying and reducing the need ... health or medical device. , ...
... model isn,t your father,s nanocar. It runs cool. , The ... versions of their creation have the ability to roll at ... be years away, the breakthrough suggests they,ll be easier to ... which had to be heated to 200 degrees Celsius before ...
... high-performing cold weather biodieselSAN FRANCISCO, Feb. 3 /PRNewswire/ ... producer of small-to-medium scale biodiesel production equipment and ... the release of "Greenline Tea FASTRACK ", ... of materials with a new equipment and process ...
Cached Biology Technology:Bluegiga Provides Health Device Profile for its Bluetooth OEM Modules 2Rice rolls out new nanocars 2Rice rolls out new nanocars 3New Greenline Tea FASTRACK Solves Cold-Flow Issues 2
... ester can be used to ... The covalently bound acridinium NHS ... the presence of hydrogen peroxide. ... be used as a detection ...
... up to 6 strain chambers with precise uniaxial ... design ensures that cells grow over long periods ... This unit allows you to control the frequency ... unique strain settings. The instrument fits in a ...
... a novel procedure for the uniform amplification ... genome DNA from small samples. This method ... and highly reproducible amplification and labeling procedure ... REPLI-g Mini Kit module (QIAGEN) and a ...
... using PULSin may be superior to transfection ... traditional transfection, with PULSin you can study ... time course of proteins in cells. Likewise, ... information than traditional RNA interference experiments. ...
Biology Products: