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High red blood cell folate levels linked to silenced tumor-suppressors
Date:12/22/2010

HOUSTON People with higher levels of folate in their red blood cells were more likely to have two tumor-suppressing genes shut down by methylation, a chemical off switch for genes, researchers report in the December issue of Cancer Prevention Research.

DNA hypermethylation, notes co-author Jean-Pierre Issa, M.D., professor in MD Anderson's Department of Leukemia, is found in a variety of cancers and diseases of aging, such as heart disease. Methyl groups attach to genes at sites called CpG islands and protrude like tags or book marks from the promoter region, preventing gene expression.

"Our new finding is that having high levels of folate in the blood, as observed in a sensitive measure of red blood cell (RBC) folate, is related to higher levels of DNA methylation," Issa said.

Folate is a naturally occurring B-vitamin that plays a role in DNA creation, repair and function as well as red blood cell production. Pregnant women who have a folate deficiency are at elevated risk of giving birth to a child with neural tube defects, which are caused by the failure of the spinal cord or brain to fully close during development.

Folate is found in leafy vegetables, fruits, dried beans and peas. Since 1998 its synthetic version, folic acid, has been added to breads cereals, flours, pastas, rice and other grain products under order from the U.S. Food and Drug Administration. This has driven down the rate of neural tube defects in the United States, according to the U.S. Centers for Disease Control and Prevention.

Folate also is taken as a dietary supplement. The recommended daily requirement is 400 micrograms for adult men and women and an additional 400 for women capable of becoming pregnant.

Folate's effect on cancer, once thought to be mainly preventive, has become less clear in recent years, with scientists finding cancer-promoting aspects of folate intake in colorectal, prostate and other cancers.

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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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