Navigation Links
High red blood cell folate levels linked to silenced tumor-suppressors
Date:12/22/2010

HOUSTON People with higher levels of folate in their red blood cells were more likely to have two tumor-suppressing genes shut down by methylation, a chemical off switch for genes, researchers report in the December issue of Cancer Prevention Research.

DNA hypermethylation, notes co-author Jean-Pierre Issa, M.D., professor in MD Anderson's Department of Leukemia, is found in a variety of cancers and diseases of aging, such as heart disease. Methyl groups attach to genes at sites called CpG islands and protrude like tags or book marks from the promoter region, preventing gene expression.

"Our new finding is that having high levels of folate in the blood, as observed in a sensitive measure of red blood cell (RBC) folate, is related to higher levels of DNA methylation," Issa said.

Folate is a naturally occurring B-vitamin that plays a role in DNA creation, repair and function as well as red blood cell production. Pregnant women who have a folate deficiency are at elevated risk of giving birth to a child with neural tube defects, which are caused by the failure of the spinal cord or brain to fully close during development.

Folate is found in leafy vegetables, fruits, dried beans and peas. Since 1998 its synthetic version, folic acid, has been added to breads cereals, flours, pastas, rice and other grain products under order from the U.S. Food and Drug Administration. This has driven down the rate of neural tube defects in the United States, according to the U.S. Centers for Disease Control and Prevention.

Folate also is taken as a dietary supplement. The recommended daily requirement is 400 micrograms for adult men and women and an additional 400 for women capable of becoming pregnant.

Folate's effect on cancer, once thought to be mainly preventive, has become less clear in recent years, with scientists finding cancer-promoting aspects of folate intake in colorectal, prostate and other cancers.

The r
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cord blood cell transplantation provides improvement for severely brain-injured child
2. Malaria-infected cells stiffen, block blood flow
3. Firefly protein lights pathway to improved detection of blood clots
4. CCNY professor gets grant to develop artificial blood
5. Scientists discover new mechanism for controlling blood sugar level
6. HIV drugs interfere with blood sugar, lead to insulin resistance
7. The lifeblood of leaves: Vein networks control plant patterns
8. Nanoengineers aim to grow tissues with functional blood vessels
9. McMaster scientists turn skin into blood
10. UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells
11. X-ray crystallography reveals structure of precursor to blood-clotting protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... Baltimore, MD, November 6, 2014 - Insilico Medicine, ... in aging and age related diseases announced a ... medicine of cancer, Champions Oncology, Inc (OTC: CSBR). ... genomics for personalized medicine, but Champions Oncology,s TumorGraft ... can validate the chemotherapy regimen experimentally generating vast ...
(Date:11/5/2014)... RENO – Kelly Redmond has dedicated his career ... knowledge to a general audience. , As deputy ... Climate Center at Nevada,s Desert Research Institute, Redmond ... the management, application and dissemination of climate data ... Annual Fall Meeting in San Francisco on December ...
(Date:11/4/2014)... SALT LAKE CITY, Nov. 5, 2014 – University of ... uses enzymes to help jet fuel produce electricity without ... can be used to power portable electronics, off-grid power ... appears online today in the American Chemical Society journal ... into electricity through a chemical reaction between a fuel ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Jet-fueled electricity at room temperature 2
... 2012 The Phoenix Community Alliance (PCA) will honor ... Institute (TGen), with its most prestigious award. Dr. ... Award for his work in improving the lives of ... such as Alzheimer,s, diabetes and many types of cancer. ...
... The National Institutes of Health has awarded The Scripps ... pathway in the development and maintenance of B-cell lymphoma, a ... normal disease fighting cells into cancers. The disease affects immune ... blood cells. John Cleveland, PhD, chair of the ...
... MD FASEB MARC (Maximizing Access to Research Careers) ... 2012 American Society for Clinical Investigation/Association of American Physicians ... 2012. These awards are meant to promote the ... the mainstream of the basic science community and to ...
Cached Biology News:Phoenix Community Alliance honors TGen's Dr. Jeffrey Trent 2Scientists win $2 million to study new pathway in development and maintenance of lymphoma 2
(Date:11/18/2014)... 2014 Cirrascale Corporation ®, ... and rackmount computing infrastructure, today announced it will ... throughout its GPU-enabled blade server and high-performance workstation ... latest proprietary 80-lane Gen3 PCIe switch-enabled risers, the ... K80 dual-GPU accelerator cards in a single blade, ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
(Date:11/18/2014)... Nov. 18, 2014 PDL BioPharma, Inc. (PDL) ... connection with the acquisition of Durata Therapeutics, Inc. by ... with the termination of PDL,s credit agreement with Durata, ... of $40 million, accrued interest, and prepayment and change ... a structured financing transaction with Durata in which PDL ...
(Date:11/17/2014)... The new METTLER TOLEDO White Paper " Traceability ... becoming the first calibration laboratory in the world ... the microgram range. National Metrology Institutes (NMI's), private ... in nanotechnology applications will benefit from understanding the ... weights in the range of 0.05 mg to ...
Breaking Biology Technology:Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3PDL BioPharma Announces Successful Conclusion of Debt Financing Agreement with Durata Therapeutics 2New White Paper on Microgram Weights Describes How to Achieve Traceable Measurement Down to 0.05 Milligrams 2
... Jan. 31, 2011 Fox Chase Cancer Center , one ... the posting of clinical outcomes data to its website ... seek cancer care.  This initiative follows on a survey Fox Chase ... success rates as the factor that would be the most ...
... China-Biotics, Inc. ("China-Biotics", the "Company") (Nasdaq: ... of probiotics products in China, today announced it will ... p.m. Beijing Time on Wednesday, February 9, 2011, to ... for the period ended December 31, 2010. ...
... Mass., Jan. 31, 2011 Haemonetics Corporation (NYSE: HAE ... net income of $19.7 million, up 8%, and earnings per share ... third quarter net income was $ 22.6 million, up 21%, and ... revenue was up 6%, adjusted net income was up 21%, and ...
Cached Biology Technology:Fox Chase Cancer Center Publishes Clinical Outcomes for Patient Use 2Fox Chase Cancer Center Publishes Clinical Outcomes for Patient Use 3China-Biotics to Report Fiscal Year 2011 Third Quarter Financial Results on February 9 2Haemonetics Reports Third Quarter of Fiscal 11 2Haemonetics Reports Third Quarter of Fiscal 11 3Haemonetics Reports Third Quarter of Fiscal 11 4Haemonetics Reports Third Quarter of Fiscal 11 5Haemonetics Reports Third Quarter of Fiscal 11 6Haemonetics Reports Third Quarter of Fiscal 11 7Haemonetics Reports Third Quarter of Fiscal 11 8Haemonetics Reports Third Quarter of Fiscal 11 9Haemonetics Reports Third Quarter of Fiscal 11 10Haemonetics Reports Third Quarter of Fiscal 11 11Haemonetics Reports Third Quarter of Fiscal 11 12Haemonetics Reports Third Quarter of Fiscal 11 13
... configured specifically for pharmaceutical powder packaging, ... are precision-joined to create ultra-smooth surfaces ... and disinfect. One-inch radius corners simplify ... strong, rigid surface without external bracing. ...
... sensitive reagent for the detection of inorganic ... of recombinant E. coli phosphate-binding protein labeled ... to changes in its environment.How it worksBinding ... rapid and tight (Kd ~ 0.1 M), ...
... This benchtop ductless exhaust hood ... allowing safe indoor release of exhaust. ... contaminants. Over 28" of vertical clearance ... glassware. Includes polypropylene spill tray; options ...
... ideal modular cleanroom for biological safety ... require cleanliness (to Class 10/ISO 3) ... to create ultra-smooth surfaces that are ... One-inch radius corners simplify cleaning. Unique ...
Biology Products: