Navigation Links
High-performance computing reveals missing genes
Date:4/13/2010

Scientists at the Virginia Bioinformatics Institute (VBI) and the Department of Computer Science at Virginia Tech have used high-performance computing to locate small genes that have been missed by scientists in their quest to define the microbial DNA sequences of life. Using an ephemeral supercomputer made up of computers from across the world, the mpiBLAST computational tool used by the researchers took only 12 hours instead of the 90 years it would have required if the work were performed on a standard personal computer.

The new study, reported in the journal BMC Bioinformatics, is the first large-scale attempt to identify undetected genes of microbes in the burgeoning GenBank DNA sequence repository that contains over 100 billion bases of DNA sequence. The genes uncovered may have important functions in the cell, but those functions need to be established by further experiment.

Skip Garner, executive director of VBI and professor of biological sciences at Virginia Tech, commented, "This is a perfect storm, where an overwhelming amount of data is analyzed by state-of-the-art computational approaches, yielding important new information about genes. These genes may be tomorrow's new targets for pharmaceutical research, for example to find new antibiotics or vaccines, which is extremely important since we need novel approaches to combat the emergence of new drug-resistant bugs."

In the past few years, enormous progress has been made in sequencing technologies that allow scientists to produce astonishing amounts of sequence data. Today more than 1200 genome sequences of microbes are housed in the GenBank database. By far one of the biggest problems facing scientists is not generating the sequence data but reliably locating and assigning a function to the many genes in a genome, a process that scientists refer to as annotation. This process crucially depends on sophisticated computational tools. The field of bioinformatics is c
'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. CareFusion Launches 10-Pound High-Performance Critical Care Ventilator in the U.S.
2. CareFusion Launches EnVe(TM) Ventilator: 10-Pound High-Performance Critical Care Ventilator
3. SRNL, automakers to develop high-performance wireless sensors networks
4. DOE awards over a billion supercomputing hours to address scientific challenges
5. Petascale computing tools could provide deeper insight into genomic evolution
6. A genomic CluE for cloud computing
7. Harnessing cloud computing for data-intensive research on oceans, galaxies
8. Cloud computing brings cost of protein research down to Earth
9. Developer of advanced computing memory, father of biochemical engineering, and innovative engineering educators win highest engineering honors of 2009
10. PNNL researchers earn top honors at Supercomputing conference
11. Multithreaded supercomputer seeks software for data-intensive computing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... the unique bioelectric signaling system of the electric fish, ... The OU researcher is working to understand how these ... used to map the world around them. Electric ... discharges a second throughout their lives. The energetic ... necessary for survival. , "There is evidence that electric ...
(Date:9/19/2014)... of fairness did not evolve for the sake of ... benefits of continued cooperation, so say Frans de Waal, ... article about inequity aversion (IA), which is defined as ... published in Science . , Their conclusion ... studies to address their hypothesis that it is the ...
(Date:9/19/2014)... 2014 Nxt-ID, Inc. (Nasdaq: NXTD and ... the growing m-commerce market, updates the "Wocket in Your Pocket" celebrity ... and light middleweight weight classes, Vinny Pazienza (PAZ). ... Game of Thrones actor Ciaran Hinds and ... star Katey Sagal have been cast in Bleed ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3
... smell the coffee and enjoy a cup of it ... get your juices flowing. It might keep you going for ... cyclist, University of Illinois kinesiology and community health professor Robert ... fuel up on caffeine prior to hitting the pavement on ...
... a genetic engineering breakthrough that could help everyone from bed-ridden ... Nobel Prize winner Mario R. Capecchihave created a "switch" that ... muscle stem cells to monitor muscle regeneration in a living ... switch, or drug, that allows people to grow new muscle ...
... CA--A Cancer Genomics Browser developed by researchers at the ... to visualize and analyze data from studies aimed at ... of the disease. The browser consists of ... find patterns in the huge amounts of clinical and ...
Cached Biology News:A little java makes it easier to jive, researcher says 2A little java makes it easier to jive, researcher says 3A little java makes it easier to jive, researcher says 4Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle 2Cancer Genomics Browser gives cancer researchers a powerful new tool 2Cancer Genomics Browser gives cancer researchers a powerful new tool 3Cancer Genomics Browser gives cancer researchers a powerful new tool 4
(Date:9/22/2014)... Manchester have generated a new star-shaped molecule made up of ... ever created. , Known as a ,Star of ... over a quarter of a century and the team,s findings ... , Consisting of two molecular triangles, entwined about each other ... tiny each triangle is 114 atoms in length around ...
(Date:9/22/2014)... YORK , Sept. 22, 2014 US ... US demand for specialty biocides is forecast to rise ... In volume terms, demand is projected to increase 1.3 ... same period. A strong rebound in construction expenditures will ... paint and coatings markets, while growth in consumer spending ...
(Date:9/22/2014)... September 22, 2014 Invisible Sentinel ... for the food and beverage industries, announced today ... distributed under a non-exclusive agreement by Enartis, a ... , Enartis, an Esseco Group company headquartered in ... in California and other global markets for their ...
(Date:9/22/2014)... LONDON , September 22, 2014 ... ended on a mixed note as the Dow Jones ... NASDAQ Composite closed at 4,579.79, down 0.30%. The S&P ... the trading session, six out of ten sectors finished ... Sector Index ended the day at 751.48, up 0.10%, ...
Breaking Biology Technology:US Biocides Market 2US Biocides Market 3Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5
... Consortium With Broad ... Portfolio of IV Products, ... BAX ) announced today that Novation, the University HealthSystem,Consortium,s (UHC) ... behalf of UHC valued at over $200 million over the,contract ...
... (Pink Sheets: BIEL), announced today that the ... sale by its,distributor, Endotherapeutics Party Limited. ... professionals of,Endotherapeutics will successfully launch ActiPatch in ... of experience in the,medical devices market and ...
... to Identify Pathways and ... to Metabolomic Data, REDWOOD CITY, Calif., Oct. ... solutions to help life science researchers,generate insights from ... solution within Ingenuity,Pathways Analysis to help researchers understand ...
Cached Biology Technology:Baxter and Novation Sign Multi-Year Contract Extension Valued at Over $200 Million for Medication Delivery Products 2Baxter and Novation Sign Multi-Year Contract Extension Valued at Over $200 Million for Medication Delivery Products 3Australian Therapeutics Goods Administration Approval for ActiPatch Achieved 2Ingenuity Systems Launches New Metabolomics Solution Within IPA 2
Contains L-glutamine...
... the 11(R)-LOs of the sea urchin, ... hydra, H. vulgaris. The biological activity ... and tentacle regeneration, respectively, in these ... aspirin-treated recombinant COX-2 is incubated with ...
Rabbit anti-T-box 6...
karyopherin alpha2 (2G7)...
Biology Products: