Navigation Links
High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
Date:2/18/2009

CINCINNATIA study by researchers at the University of Cincinnati (UC) shows that high-fat diets, even if consumed for a short amount of time, can inflame fat tissue surrounding blood vessels, possibly contributing to cardiovascular disease.

These findings will be published in the Feb. 20 edition of the American Heart Association journal Circulation Research.

Neal Weintraub, MD, and colleagues examined adipose tissueor fatsurrounding the coronary arteries of humans. The researchers found these fat cells to be highly inflamed, suggesting that they could trigger inflammation of the blood vessels, an important component of atherosclerosis.

They also found that the inflammation of fat tissues around the arteries of mice is increased by feeding the animals a high-fat diet for just two weeks.

"This is independent of weight gain or blood lipidscholesterol levels," says Weintraub, senior author of the study and chair of the cardiovascular diseases division at UC.

Weintraub says that high fat diets contribute to atherosclerosisor the hardening of arteriesin a number of ways.

"Elevated blood lipidsor cholesterol levelscan worsen with the intake of high fat diets, and this is known to contribute to atherosclerosis," he says. "However, many patients who consume high fat diets do not exhibit abnormal lipid profiles but still develop atherosclerosis nonetheless.

"These new findings suggest a direct link between poor dietary habits and inflammation of blood vessels, mediated by the fat cells surrounding the blood vessel wall."

Weintraub adds that the diet fed to the mouse models was not unlike the diets consumed by many Americans.

"It produced striking abnormalities of the fat tissue surrounding blood vessels in a very short period of time," he says. "This is a warning to those who say there isn't a problem because their weight and cholesterol levels are under control. Lipid profiles don't hold all the answers.

"Bad dietary habits can lead to a number of problems, and this suggests that a high fat diet is detrimental in ways we didn't previously understand."

Weintraub says there is no real way to measure the effects of poor dietary habits on fat tissue surrounding blood vessels.

"We don't know why these cells are so responsive to high-fat diets," he says. "We must now conduct further experiments to answer these types of questions."


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

Related biology news :

1. New discovery could reduce the health risk of high-fat foods
2. Scientists discover why a mothers high-fat diet contributes to obesity in her children
3. Sea otter study reveals striking variability in diets and feeding strategies
4. New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets
5. U of M finds teens who eat breakfast daily eat healthier diets than those who skip breakfast
6. Eliminating soda from school diets does not affect overall consumption
7. Low-carb diets can affect dieters cognition skills
8. Nutrigenomics -- developing personalized diets for disease prevention
9. Scientists find link between inflamed gums and heart disease
10. A step toward tissue-engineered heart structures for children
11. Researchers create system to build transplant tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... 15, 2016 Yissum Research Development Company ... company of the Hebrew University, announced today the formation ... technology of various human biological indicators. Neteera Technologies has ... from private investors. ... detection of electromagnetic emissions from sweat ducts, enables reliable ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
(Date:3/8/2016)... March 8, 2016   Valencell , the ... announced it has secured $11M in Series D ... a new venture fund being launched by UAE-based ... from existing investors TDF Ventures and WSJ Joshua ... continue its triple-digit growth and accelerate its pioneering ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... Oxitec CEO Hadyn Parry will testify ... before the United States House Committee on Science, Space and ... controlling the spread of the Aedes aegypti mosquito, ... (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) Oxitec has pioneered ... in Brazil , Panama ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... molecular nanotechnology, announced the winners for the 2015 Foresight Institute Feynman Prizes. ... given in two categories, one for experiment and the other for theory in ...
(Date:5/20/2016)... ... 20, 2016 , ... Kablooe Design, a leading provider of product design and ... anniversary of the business. “We have worked hard to build long-term relationships,” says President ... privilege and honor of serving their product design and development needs through the years.” ...
(Date:5/19/2016)... ... May 19, 2016 , ... Anton Paar USA, located in ... office building is complete. The new structure adds a third office building to the ... USA purchased 2.4 acres of land, along with office space adjacent to the ...
Breaking Biology Technology: