Navigation Links
High-fat diet during puberty linked to breast cancer risk later in life
Date:8/31/2010

EAST LANSING, Mich. Girls eating a high-fat diet during puberty, even those who do not become overweight or obese, may be at a greater risk of developing breast cancer later in life, according to Michigan State University researchers.

The implications that a high-fat diet may have detrimental effects independent of its effect to cause obesity could drive new cancer prevention efforts.

The findings come from research at MSU's Breast Cancer and the Environment Research Center, established in 2003 and funded through 2010 by the National Institute of Environmental Health Sciences and the National Cancer Institute.

Physiology professor Sandra Haslam, director of the center, and Richard Schwartz, microbiology professor and associate dean in the College of Natural Science, are now expanding that research with a new, five-year, $2.3 million federal grant. They will use that funding to continue their work studying the impact of prenatal-to-adult environmental exposures that predispose women to breast cancer as part of the extended nationwide Breast Cancer and the Environment Research Program.

"The pubertal time period is crucial, as this is when the basic framework is created for mammary gland development," Haslam said. "What we are seeing from preliminary research in animals is that a high-fat diet during puberty can lead to the production of inflammatory products in the mammary glands of adults, which can promote cancer growth."

The work builds on the team's previous research that found the hormone progesterone activates genes that trigger inflammation in the mammary gland; that inflammation may be a key factor in increasing the risk of breast cancer. Those findings were published last year in the Journal of Steroid Biochemistry and Molecular Biology.

Haslam and Schwartz discovered that a high-fat diet during puberty produced many of the same effects seen as part of their progesterone research.

"Understanding what genes were turned on by progesterone led us to look at some of the same suspects with high-fat diets," Schwartz said. "It appears both processes may lead to inflammation in the mammary glands."

Since these inflammatory changes first occur during the crucial time of puberty, a period of intense development and cell division, it can have effects lasting a lifetime.

To test their findings, Haslam and Schwartz will lead a team analyzing two different mouse models of breast cancer and the effects of high-fat diets during puberty. They also will test several anti-inflammation interventions designed to overcome the negative effects of a high-fat diet on inflammation.

The initial MSU Breast Cancer and the Environment Research Center brought together researchers from MSU's colleges of Natural Science, Human Medicine and Veterinary Medicine to perform research into environmental impacts during puberty that affect breast cancer risk, as well as researchers in the College of Communication Arts and Sciences to study how to best communicate breast cancer health messages to the public.

The next phase of the studies will be through the expanded national Breast Cancer and the Environment Research Program. Besides performing biomedical research, the new project also will strive to communicate findings that can lessen the risk of breast cancer via awareness and avoidance of environmental risk factors. To that end, the Michigan Breast Cancer Coalition and colleagues in MSU's College of Communication Arts and Sciences are helping bring research findings to the public.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Related biology news :

1. Scientists discover why a mothers high-fat diet contributes to obesity in her children
2. High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
3. Researchers uncover obesity gene involved in weight gain response to high-fat diet
4. High-fat diet affects physical and memory abilities of rats after 9 days
5. Do high-fat diets make us stupid and lazy?
6. TV bombards children with commercials for high-fat and high-sugar foods
7. Flavonoids in orange juice suppress oxidative stress from high-fat, high-carb meal
8. Experts discuss climate change during UH lecture series
9. During exercise, the human brain shifts into high gear on alternative energy
10. New study indicates link between weight gains during pregnancy and dieting history
11. Rethinking who should be considered essential during a pandemic flu outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics today announced ... comes after the company changed focus to making analytical tools for biopharmaceutical quality ... new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart and David ...
(Date:4/19/2017)... New York, NY (PRWEB) , ... April 19, ... ... working to combat Clostridium difficile (C. diff) infections through education and advocacy. ... lost her life to a C. diff infection, the foundation has become the ...
(Date:4/19/2017)... April 19, 2017  As a Bronze ... Heroin Summit ,  Proove® Biosciences, Inc. announces ... environmental, and lifestyle factors to accurately predict prescription ... of Southern California (USC), the Interventional Pain Institute ... publish results showing that Proove Opioid Risk® accurately ...
(Date:4/19/2017)... 2017   Thermo Fisher Scientific Inc . ... MOnitoring SEpsis (MOSES) Study have been published in ... Care Medicine . Researchers from the study, titled ... Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) ... (procalcitonin) assay to assess risk for 28 day ...
Breaking Biology Technology: