Navigation Links
High dietary phosphate intake may promote skin cancer formation
Date:3/23/2010

A high dietary intake of phosphate promotes tumor formation in an animal model of skin cancer, researchers at Emory University School of Medicine have found. The results, published in the journal Cancer Prevention Research, suggest that a high intake of phosphates may promote tumor development and contribute to tumor growth in skin cancer, while restricting phosphate intake may help prevent cancer.

The researchers applied dimethylbenzanthracene, a carcinogen found in cigarette smoke, to the skins of mice, followed by another chemical that stimulates cell growth. Feeding these mice a high phosphate diet (1.2 percent by weight) increased skin papilloma number by 50 percent compared with a low phosphate diet (0.2 percent). Skin papillomas are the initial stage of skin cancer development, which may progress to full carcinoma.

"This is a very well established model for the initiation and progression of cancer, and the effects of many physiological conditions on cancer initiation have been measured this way," says senior author George Beck, PhD, assistant professor of medicine (endocrinology). Beck also is a member of the Winship Cancer Institute, Emory University.

Phosphate is an essential nutrient forming both the physical support for bones, when complexed with calcium, and the chemical backbone of DNA. Phosphate chemical bonds provide the energy currency in the cell, in the form of ATP (adenosine triphosphate). In addition, many oncogenes, the motors driving cancer cells to divide relentlessly, are regulatory enzymes that attach phosphate chemically to other proteins, turning their activity up or down depending on the protein target.

Altered levels of phosphate could be tipping the balance of these chemical reactions in complex ways, Beck says.

Public health researchers say that phosphate dietary intake has increased over the last 30 years and also may be underestimated because of the increasing contribution of
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dietary supplements discouraged for prostate cancer patients
2. Dietary factors influence ovarian cancer survival rates
3. Researchers develop dietary formula that maintains youthful function into old age
4. Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths
5. Dietary supplements manufacturers gain new tool to help ensure quality products
6. Two dietary oils, two sets of benefits for older women with diabetes
7. Following the dietary guidelines may slow heart disease in women
8. Desert woodrats switch one dietary poison for another
9. Desert woodrats switch one dietary poison for another
10. Results of the third school nutrition dietary assessment study published
11. Annual Bibliography of Significant Advances in Dietary Supplement Research 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... pledge of $1 million from the Cornelia Cogswell Rossi ... Biometry Center. , The newly established Connie ... to develop a greater breadth and depth of knowledge ... the pace of research to improve human health. , ... for the Laboratory and its external partners, supporting research ...
(Date:7/30/2014)... July 30, 2014 ResearchMoz ... Government Biometric Systems Market 2014-2024   Business Strategies, Industry ... Biometric Systems Market 2014-2024" offers the reader detailed ... the next ten years, alongside potential market opportunities ... forecasts. To view the table of ...
(Date:7/30/2014)... across-the-board increase in Impact Factors for its molecular ... Reports (Thomson Reuters, 2014) show that Clinical ... in Biochemistry , Biochemical Society Transactions ... in their Impact Factors. The journals are owned ... Press Limited. , 2014 Impact Factors (2013 Impact ...
Breaking Biology News(10 mins):Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10Across-the-board Impact Factor increases for Portland Press Limited 2
... / b3c newswire / - Kinaxo Biotechnologies GmbH has ... identify the protein kinase mTOR as a new ... a non-steroidal, anti-inflammatory Cox-2 inhibitor approved for the ... In addition, celecoxib’s anti-proliferative effect has earned it ...
... of memories for a lifetime. But when our eyes ... also creates temporary memories that help us process complex ... For decades, scientists have held that such short-term memories ... the course of several seconds. Now researchers at ...
... of healthy people can cause serious infections in premature ... university Karolinska Institutet have now found an explanation for ... to the skin and quickly develop dynamic ecosystems: the ... establishes itself on the child,s skin and mucous ...
Cached Biology News:KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex 2Some short-term memories die suddenly, no fading 2Tufted bacteria cause infection in premature babies 2
(Date:7/29/2014)... DIEGO , July 29, 2014   Sequenom, ... sciences company that provides innovative genetic analysis solutions, and ... of esoteric laboratory services in the United ... noninvasive prenatal testing patents and applications. "We ... innovation, and patient care, and we welcome the opportunity ...
(Date:7/29/2014)... Can a particle be separated from its properties? On ... published the results of the first Cheshire Cat experiment, ... Chapman University in Orange, CA, and Vienna University of ... without a grin," thought Alice in Wonderland, "but a ... I ever saw in my life!" Alice,s surprise stems ...
(Date:7/29/2014)... researchers has created a new way of manufacturing ... surfaces, made by self-assembly of carbon nanotubes, could ... controllable mechanical stiffness and strength, or the ability ... "We have demonstrated that mechanical forces can be ... microstructures, and that we can independently control ...
(Date:7/29/2014)... , July 29, 2014  Pomerantz LLP is ... Inc. ("Impax" or the "Company") (NASDAQ: IPXL).  Such investors ... at rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... its officers and/or directors have violated Sections 10(b) and ... On July 29, 2014, Impax Laboratories, Inc. ...
Breaking Biology Technology:Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4A new way to make microstructured surfaces 2SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2
... KALAMAZOO, Mich., Oct. 28 Stryker Corporation (NYSE: SYK ... District of Massachusetts has returned an indictment charging Stryker Biotech ... with wire fraud, conspiracy to defraud the U.S. Food and ... statements to the FDA. The Company disclosed in March of ...
... INCLINE VILLAGE, Nev., Oct. 28 PDL BioPharma, Inc. ... has priced a $300 million securitization transaction intended to ... , Upon closing of the transaction, which is expected ... sell to QHP Royalty Sub LLC ("QHP"), a newly-formed ...
... , GAITHERSBURG, Md., Oct. 28 GenVec, Inc. (Nasdaq: ... the third quarter ended September 30, 2009 on Thursday, November ... call at 10:00 a.m. EST on Friday, November 6, 2009 ... http://www.newscom.com/cgi-bin/prnh/20081205/DC50112LOGO ) , To listen to ...
Cached Biology Technology:Stryker Statement in Response to the Indictment of Its Biotech Division 2PDL BioPharma Announces Pricing of $300,000,000 Securitization Transaction 2PDL BioPharma Announces Pricing of $300,000,000 Securitization Transaction 3GenVec Announces Third Quarter 2009 Results Conference Call 2
Recombinant Feline IL-2, CF...
Recombinant Equine IL-4, CF...
Recombinant Rat Leptin, CF...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: