Navigation Links
High cholesterol fuels the growth and spread of breast cancer
Date:11/28/2013

DURHAM, N.C. A byproduct of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancers, researchers at the Duke Cancer Institute report.

The researchers also found that anti-cholesterol drugs such as statins appear to diminish the effect of this estrogen-like molecule.

Published in the Nov. 29, 2013, edition of the journal Science, the findings are early, using mouse models and tumor cells. But the research for the first time explains the link between high cholesterol and breast cancer, especially in post-menopausal women, and suggests that dietary changes or therapies to reduce cholesterol may also offer a simple, accessible way to reduce breast cancer risk.

"A lot of studies have shown a connection between obesity and breast cancer, and specifically that elevated cholesterol is associated with breast cancer risk, but no mechanism has been identified," said senior author Donald McDonnell, Ph.D., chair of the Department of Pharmacology and Cancer Biology at Duke. "What we have now found is a molecule not cholesterol itself, but an abundant metabolite of cholesterol called 27HC that mimics the hormone estrogen and can independently drive the growth of breast cancer."

The hormone estrogen feeds an estimated 75 percent of all breast cancers. In a key earlier finding from McDonnell's lab, researchers determined that 27-hydroxycholesterol or 27HC behaved similarly to estrogen in animals.

For their current work, the researchers set out to determine whether this estrogen activity was sufficient on its own to promote breast cancer growth and metastasis, and whether controlling it would have a converse effect.

Using mouse models that are highly predictive of what occurs in humans, McDonnell and colleagues demonstrated the direct involvement of 27HC in breast tumor growth, as well as the aggressiveness of the cancer to spread to other organ
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Amgen Presents Pooled Analysis Showing AMG 145 Significantly Reduced LDL Cholesterol In Over 1,200 Patients
2. Nordic diet lowers cholesterol, study finds
3. 4 genes indentified that influence levels of bad cholesterol
4. U-M researchers find new way to clear cholesterol from the blood
5. Cholesterol rafts deliver drugs inside cancer cells
6. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
7. Study identifies liver gene that regulates cholesterol and fat blood levels
8. Cholesterol helps regulate key signaling proteins in the cell
9. Host cholesterol secretion likely to influence gut microbiota
10. Vitamin D supplements do not improve cholesterol as previous research suggested
11. Zebrafish research shows how dietary fat regulates cholesterol absorption
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High cholesterol fuels the growth and spread of breast cancer
(Date:5/19/2015)... , May 19, 2015 ... has announced the addition of the  "Genetic ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent ... an in-depth analysis of the current and ... of gene-based tests, their working principles and ...
(Date:5/14/2015)... and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) has announced ... Smart Mobile Devices " report to their offering. ... watershed year for fingerprint sensors in smartphones and tablets, ... fingerprint sensors a raison d,etre in the mobile milieu ... must-have feature in flagship smartphones. The key ...
(Date:5/11/2015)... May 11, 2015  Synaptics Incorporated (NASDAQ: ... solutions, today announced the appointment of Wajid ... Financial Officer, reporting to Rick Bergman , ... Chief Financial Officer, Kathleen Bayless , who ... Mr. Ali brings extensive financial management expertise ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... professor Sandy Pentland, former Advertising Research Foundation Chief Research Officer ... June 23 Innerscope Research (R), a ... added two new members to its Advisory Board who will ... the measurement and application of Emotional Engagement. , , ...
... PARK, Calif., June 29 Kornberg Associates | Architects ( ... University to design a new Cognitive & Neurobiological Imaging ... The firm has worked with Stanford University ... 30 years, one of which is the two-story, 32,000 square-foot ...
... an award-winning biometric technology research and development firm, ... with ACS Technologies, the leading provider of information ... other faith-based organizations. , , Through the ... offering Bio-SnapON(TM), a robust biometric identification system developed ...
Cached Biology News:Innerscope Research Adds to Its Advisory Board Two Pioneers in the Measurement and Application of Emotional Engagement 2Kornberg Associates Architects Selected to Develop Design for New Stanford University Imaging Center 2ACS Technologies(TM) Selects M2SYS for Innovative Biometric Software 2
(Date:5/21/2015)... , May 21, 2015  Prima Biomed Ltd. (NASDAQ: ... is striving to become a leader in the development ... announced that the final CVac data from the Phase ... clear trend for a clinically meaningful improvement in Overall ... remission patients. In the group of second ...
(Date:5/21/2015)... Patent Offering, The patent’s technology pertains ... therapeutic imaging within a body lumen (open space). ... a low cost, single-use disposable illumination and camera module ... 18, 2013 and the patent approval was received on ... to customize the lighting and magnification of the endoscope ...
(Date:5/21/2015)... 21, 2015 Veolia’s environmental monitoring ... North American distribution agreement with VWR to distribute ... With more than 160 years of experience, VWR, ... for laboratory and production facilities, has cultivated a ... differentiated services to enable science. Endetec’s TECTA™ ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) has ... Market Outlook 2020 " report to their offering. ... regenerative medicine is expected to have huge marketing potential. ... in the growth of deregulated organs. Several therapeutic molecules ... to form new tissue or sometimes organ transplant is ...
Breaking Biology Technology:Correction Continues after Big Move - BrokerBank Securities, Inc. 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... Inc. (Nasdaq:,BIOD) today announced the addition of Brian ... Dr. Pereira is the President and CEO of ... development and,commercialization of therapeutic and diagnostic products. At ... advancing the,company,s key product candidate, Ferumoxytol, towards marketing ...
... Nov. 21 Syngenta and the Royal,Society of Chemistry ... to help promote the economic and social development of,the ... continent,is being established initially in Kenya. Its purpose is ... to achieve greater levels of,innovation and scientific development., ...
... Breathing new life into an old idea, ... are developing innovative materials for controlling temperatures that ... more efficient car engines, photovoltaic cells and electronic ... resulted in a new consumer product: a simple, ...
Cached Biology Technology:Brian J.G. Pereira, M.D. Joins Biodel's Board of Directors 2Brian J.G. Pereira, M.D. Joins Biodel's Board of Directors 3Brian J.G. Pereira, M.D. Joins Biodel's Board of Directors 4Syngenta and The Royal Society of Chemistry Launch African Science Initiative 2Syngenta and The Royal Society of Chemistry Launch African Science Initiative 3MIT: Thermoelectric materials are 1 key to energy savings 2MIT: Thermoelectric materials are 1 key to energy savings 3