Navigation Links
High blood sugar's impact on immune system holds clues to improving islet cell transplants
Date:12/17/2008

l of Immunology. In fact, the early recipients did not require immunosuppression, which transplants patients receive to reduce the risk that their new insulin-producing cells also will become targets for their immune system. However, this generalized immune suppression puts patients at increased risk for infections, cancer and other diseases. "Basically, your guard is down," Dr. Pacholczyk said.

Seventy percent of mice that got transplants two days after they became hyperglycemic did not need immunosuppression, the Canadian researchers found; after nine days, the acceptance rate was reduced to about 10 percent. "The question is why?" Dr. Pacholczyk said.

Typically the path isn't easy for transplanted cells. Many die from the stress of transplantation or immune system attack either because they are rejected as invaders or because the same autoreactive mechanism that led to destruction of the patient's own cells is resurrected. "Cells that survive are the ones being counted on. Over time, they should increase in mass to a level that should produce sufficient amounts of insulin," the researcher said.

Type 1 diabetes results from the wrong mix of genes and environmental triggers. For example, early exposure of a genetically predisposed child to cow's milk and a viral infection could trigger an immune response to bovine insulin which, in turn, leads to islet cell destruction.

The researcher's animal model reflects the human condition fairly well; it's inbred to have diabetes but Dr. Pacholczyk developed a system to chemically induce the disease when he wants so he'll know exactly when islet cells are destroyed by the immune system. He'll document hyperglycemia's impact on all immune cells with the long term goals of identifying the magic that enables acceptance of islet cells and finding a safer, more direct way to replicate it.

In 2007, he and colleague Dr. Leszek Ignatowicz caused a stir in the scientific community when th
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Using the other guys toolkit: Similarities of pumping blood, oil examined
2. Master gene plays key role in blood sugar levels
3. Caltech scientists develop barcode chip for cheap, fast blood tests
4. Scripps research scientists identify blood component that turns bacteria virulent
5. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
6. Femtomolar optical tweezers may enable sensitive blood tests
7. Battling bacteria in the blood: Researchers tackle deadly infections
8. Apelin hormone injections powerfully lower blood sugar
9. Building the blood-brain barrier
10. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
11. On the trail of a targeted therapy for blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High blood sugar's impact on immune system holds clues to improving islet cell transplants
(Date:8/22/2014)... Thanks to important discoveries in basic and clinical ... has mobilized into a complex offensive spanning multiple ... Alberta chemistry lab could help find new and ... a compound that targets a specific enzyme overexpressed ... in cells from brain tumours. , Chemistry professor ...
(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
(Date:8/22/2014)... the birds and the bees. But that old ... fertilized. The fertilization process for flowering plants is ... male and female reproductive cells. New research from ... Munich, and including Carnegie,s Wolf Frommer, David Ehrhardt, ... signaling process that guides flowering plant fertilization. It ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Calcium and reproduction go together 2
... and philosophers across the nation are protesting a new ... a letter sent Monday to U.S. Secretary of the ... Public Works, and the House Committee on Natural Resources, ... legal opinion from the Solicitor of the U.S. Department ...
... to a new brain study, even people who seemed resilient but ... toppled on Sept. 11, 2001, have brains that are more reactive ... away. , That is the finding of a new Cornell study ... post-traumatic stress disorder (PTSD) or major depression. One of the first ...
... launched to try to boost the income of the world’s ... provide consumers with more nutritious, better tasting food. , New ... rice varieties that could fetch a higher price from consumers, ... The main aim of the new International Network for Quality ...
Cached Biology News:Legal ruling may put endangered species in danger 2Traumas like Sept. 11 make brains more reactive to fear 2New knowledge improves rice quality 2
(Date:8/22/2014)... The AMA is pleased to share ... Alaska that Alaska Governor Sean Parnell has signed House ... public use of Unmanned Aircraft Systems and the continuation ... 255states that it is, “An Act relating to unmanned ... unmanned aircraft system.” It defines State of Alaska laws ...
(Date:8/22/2014)... Canada (PRWEB) August 22, 2014 ... in model organisms can be accelerated by exome ... and manufacturing technologies, the custom SeqCap EZ Developer ... research. , Mr. Watson will additionally present how ... with commercially available human and mouse exome kits. ...
(Date:8/21/2014)... 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products marketed as XIAFLEX ® ... U.S. and XIAPEX ® in the EU, ... randomized, double-blind Phase 2a study of CCH for ... panniculopathy. The results showed that all three doses ...
(Date:8/21/2014)... A Finnish-Swedish research group at the Institute for ... Karolinska institutet, Stockholm, has developed a novel "man ... infection. This innovative diagnostic aid was described in ... August. The method is based on computer vision ... systems combined with visualization of only the diagnostically ...
Breaking Biology Technology:State of Alaska Signs Unmanned Aircraft Systems Bill 2Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2
... Forecasts Growth of More Than 40%, NEW ... /Xinhua-PRNewswire-,FirstCall/ -- China Pharma Holdings, Inc. ("China Pharma") ... generic and brand,bio-pharmaceutical products in China, announced today ... to exceed 40%., According to recent sales ...
... Genome,Sciences, Inc. (Nasdaq: HGSI ) announced today that ... be webcast and may be accessed at, http://www.hgsi.com , ... of Human Genome Sciences, senior management team will present,a ... am Eastern,Time., Investors interested in listening to the ...
... physicians credentialed,to practice at the Texas Institute for Surgery ... at its annual Best Doctors event., "Texas Institute ... in the country and it is a tremendous honor ... this prestigious list. The physicians who,operate at TIS are ...
Cached Biology Technology:China Pharma Holdings, Inc. Projects 3rd Quarter 2008 Revenue Growth to Exceed 40% 2Annual List of 'Best Doctors in Dallas' Showcases Texas Institute for Surgery Physicians 2
This antibody detects cdc42 on SDS-PAGE immunoblots....
Goat polyclonal to DDDDK tag (FITC) ( Abpromise for all tested applications)....
Rabbit polyclonal to TRPM8 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 79054 SwissProtID: Q3YFM7...
...
Biology Products: