Navigation Links
High blood sugar's impact on immune system holds clues to improving islet cell transplants
Date:12/17/2008

l of Immunology. In fact, the early recipients did not require immunosuppression, which transplants patients receive to reduce the risk that their new insulin-producing cells also will become targets for their immune system. However, this generalized immune suppression puts patients at increased risk for infections, cancer and other diseases. "Basically, your guard is down," Dr. Pacholczyk said.

Seventy percent of mice that got transplants two days after they became hyperglycemic did not need immunosuppression, the Canadian researchers found; after nine days, the acceptance rate was reduced to about 10 percent. "The question is why?" Dr. Pacholczyk said.

Typically the path isn't easy for transplanted cells. Many die from the stress of transplantation or immune system attack either because they are rejected as invaders or because the same autoreactive mechanism that led to destruction of the patient's own cells is resurrected. "Cells that survive are the ones being counted on. Over time, they should increase in mass to a level that should produce sufficient amounts of insulin," the researcher said.

Type 1 diabetes results from the wrong mix of genes and environmental triggers. For example, early exposure of a genetically predisposed child to cow's milk and a viral infection could trigger an immune response to bovine insulin which, in turn, leads to islet cell destruction.

The researcher's animal model reflects the human condition fairly well; it's inbred to have diabetes but Dr. Pacholczyk developed a system to chemically induce the disease when he wants so he'll know exactly when islet cells are destroyed by the immune system. He'll document hyperglycemia's impact on all immune cells with the long term goals of identifying the magic that enables acceptance of islet cells and finding a safer, more direct way to replicate it.

In 2007, he and colleague Dr. Leszek Ignatowicz caused a stir in the scientific community when th
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Using the other guys toolkit: Similarities of pumping blood, oil examined
2. Master gene plays key role in blood sugar levels
3. Caltech scientists develop barcode chip for cheap, fast blood tests
4. Scripps research scientists identify blood component that turns bacteria virulent
5. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
6. Femtomolar optical tweezers may enable sensitive blood tests
7. Battling bacteria in the blood: Researchers tackle deadly infections
8. Apelin hormone injections powerfully lower blood sugar
9. Building the blood-brain barrier
10. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
11. On the trail of a targeted therapy for blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High blood sugar's impact on immune system holds clues to improving islet cell transplants
(Date:3/24/2015)... 24, 2015   Crossmatch ™, a leading ... that its U.are.U ® 4500 Fingerprint Readers ... Bros . to achieve PCI compliance for Point-of-Sale ... to the POS terminal, protecting the retailer and ... breaches. With one-third of worldwide ...
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces its biometric payment ... campaign on CNBC television starting March 30 th . ... airing in New York markets. ... "We are excited about our new ad campaign following the ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... TEMPE, Ariz. Research conducted in a computerized ... University, including Nobel laureate Elinor Ostrom, show how common-pool ... even bandwidth can be managed effectively by self-organized ... published April 30 in the journal Science . ...
... Protection Agency (EPA) is making it easier to find ... ToxRefDB, which allows scientists and the interested public to ... hundreds of chemicals. ToxRefDB captures 30 years and $2 ... chemicals are in commerce and current chemical testing is ...
... Williams of Baltimore was hired by Carnegie,s Department of Embryology ... program for inner city youth. Now as head technician and ... two degrees from Johns Hopkins University under her belt, she ... has been acknowledged for technical assistance on countless others. Genetics ...
Cached Biology News:Communication trumps penalties in new study of social-ecological systems 2Communication trumps penalties in new study of social-ecological systems 3US Environmental Protection Agency opens access to chemical information 2From lab dishwasher to distinguished researcher 2From lab dishwasher to distinguished researcher 3
(Date:4/30/2015)... PARK, Calif. , April 30, 2015  Asterias ... in the emerging field of regenerative medicine, today announced ... results on Thursday, May 7, 2015 after the close ... a conference call and webcast on Thursday, May 7, ... to discuss the results and recent corporate developments. ...
(Date:4/30/2015)... (PRWEB) April 30, 2015 Available ... at http://www.lespausa.com , Fleur’s ... product combining the benefits of makeup, skin care ... subtly tinted cream is designed with specific complexion-correcting ... an even complexion and a healthy glow. Far ...
(Date:4/30/2015)... Clinovo Staffing Solutions will ... held in Orlando, FL on May 17-20th, 2015. ... Leslie Kolman, Manager of Staffing Solutions, will present Clinovo’s ... Booth #17. , “We are excited to be ... Says Trisha Heredia, Senior Director of Staffing Solutions at ...
(Date:4/29/2015)... BALTIMORE, Maryland, USA (PRWEB) April 29, 2015 ... photonics, optical sensing, and imaging on the East Coast, ... government program managers, researchers, applications developers, and industry suppliers ... sensing and imaging for multiple applications. , The event ... security, and commercial and scientific sensing and imaging -- ...
Breaking Biology Technology:Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 2Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 3SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4
... Sept. 21 Emissary Capital Group, Inc. has initiated ... SNBP) with a Buy rating and target price of ... Ying Pharmaceutical Co. Ltd., is a fully integrated and ... distribution of biopharmaceutical products. The company focuses primarily ...
... , , ... Bulletin Board: GOVX) (the "Company"), an Atlanta-based, biopharmaceutical company developing ... and other infectious agents, today announced that it has requested ... and Drug Administration (FDA) to discuss a proposed IND for ...
... BETHESDA, Md., Sept. 21 Micromet, Inc. (Nasdaq: ... antibodies for the treatment of cancer, inflammation and autoimmune diseases, ... clinical study for BiTE antibody MT110, the first T-cell engaging ... were presented at the Multidisciplinary Congress of the European ...
Cached Biology Technology:Emissary Capital Group Initiates Coverage on Sinobiopharma 2GeoVax Labs Requests pre-IND Meeting With FDA 2GeoVax Labs Requests pre-IND Meeting With FDA 3Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 2Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 3Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 4
...
...
Alexa Fluor 647 anti-mouse Qa-2...
... Luminex 100 IS System is ideal for ... Beadlyte reagents. This system contains the new, ... by Luminex. The user can design specific ... The system has fully integrated graphing and ...
Biology Products: