Navigation Links
High blood sugar's impact on immune system holds clues to improving islet cell transplants
Date:12/17/2008

AUGUSTA, Ga. A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientist.

In type 1, the immune system attacks insulin-producing cells causing high blood glucose levels that may temporarily reduce the attack, said Dr. Rafal Pacholczyk, an immunologist in the MCG Center for Biotechnology and Genomic Medicine.

He just received a three-year, $495,000 grant from Juvenile Diabetes Research Foundation to find out whether this counteraction offers insight for transplants.

High blood glucose, or hyperglycemia, causes all sorts of dysregulation throughout the body. "It throws off metabolism, hormonal interplay and increases the risk of severe infections," Dr. Pacholczyk said. A shot of insulin or an islet cell transplant normalizes blood glucose levels, enabling, among other things, restoration of the usual balance between effector T cells which mount an immune or autoimmune response and regulatory T cells which suppress attacks.

He's obviously not saying hyperglycemia is good; in fact if diabetics were to get a transplant while their blood glucose was high the procedure alone could be lethal. But Dr. Pacholczyk hypothesizes it causes a temporary shift in the immune playing field that gives advantage to regulatory T-cells long enough for the body to accept the transplanted cells. One reason may be that suppressive regulatory cells recover differently or are less influenced by hyperglycemia.

Researchers at Canada's University of Alberta were the ones to find high blood glucose causes a short-lived suppression of the attack mode of the immune system followed by a slow return of homeostasis. The result: Islet cell transplants done in mice immediately after a blood glucose spike were dramatically more successful than those done days later, according to the research published in 2007 in the Scandinavian Journa
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Using the other guys toolkit: Similarities of pumping blood, oil examined
2. Master gene plays key role in blood sugar levels
3. Caltech scientists develop barcode chip for cheap, fast blood tests
4. Scripps research scientists identify blood component that turns bacteria virulent
5. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
6. Femtomolar optical tweezers may enable sensitive blood tests
7. Battling bacteria in the blood: Researchers tackle deadly infections
8. Apelin hormone injections powerfully lower blood sugar
9. Building the blood-brain barrier
10. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
11. On the trail of a targeted therapy for blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High blood sugar's impact on immune system holds clues to improving islet cell transplants
(Date:9/17/2014)... Biomedical Informatics at IMIM (Hospital del Mar Medical Research ... have recently published a study in eLife ... role in the evolution of new proteins, some of ... discovered., Ribosomes produce proteins from the instructions found in ... genome is RNA containing information for the synthesis of ...
(Date:9/17/2014)... Mutations in the human retinoblastoma protein gene are ... University scientists have turned to fruit fly eyes to ... , In a paper featured on the cover of ... Chemistry , Michigan State University researchers provide the first ... those present in the human cancer gene, said Irina ...
(Date:9/17/2014)... R.I. [Brown University] After decades of decline, grasses ... saltmarshes. To the eye, the marsh in those places ... that a key service of the marsh coastal ... back but the ecosystem function hasn,t come back," said ... senior author of the study in the journal ...
Breaking Biology News(10 mins):Parts of genome without a known function may play a key role in the birth of new proteins 2Abnormal properties of cancer protein revealed in fly eyes 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... of Minnesota researchers are a key step closer to making ... funded by a $2.2 million United States Department of Energy ... in January, made the critical step by figuring out how ... the bacteria into ketones, which can be cracked to make ...
... ID An a l ... risk management, today announced the addition of three senior executives ... Steven Seoane has joined the company as vice president of ... Rando as director of analytics. Seoane, Barr and Rando bring ...
... of Wisconsin-Madison limnologist Stephen Carpenter has been awarded ... prestigious award for water-related activities, it was announced ... The award, which comes with $150,000 and a ... "whose work contributes broadly to the conservation and ...
Cached Biology News:U of M researchers close in on technology for making renewable petroleum 2ID Analytics Strengthens Management Team With Appointment of Senior Executives 2ID Analytics Strengthens Management Team With Appointment of Senior Executives 3UW-Madison lake scientist gets world's top water prize 2
(Date:9/18/2014)... 2014   Sigma-Aldrich Corporation (Nasdaq: ... into a new gene editing partnership with the ... Under the partnership, Sigma-Aldrich will provide the Vector ... and dedicated gene editing bioinformaticians. The ... at the U-M Medical School. One initiative already ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
(Date:9/18/2014)... new microscopy technology that allows them to view ... , Dubbed "Complementation Activated Light Microscopy" (CALM), the ... order of magnitude finer than conventional optical microscopy, ... at the nanometer scale. , In a paper ... , the researchers behind CALM used it to ...
(Date:9/18/2014)... California (PRWEB) September 18, 2014 Silicon-valley ... forces with Digitaliza TXT , the latest addition ... to its Clinical Research Organization (CRO) Program, Clinovo further ... “After three days of ClinCapture training, we are now ... TXT CEO Ana Pulido. “We can also rely on ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 3
... August 28 XTL Biopharmaceuticals,Ltd. (NASDAQ: XTLB ... in the acquisition, development and commercialization of,therapeutics for ... and hepatitis C, today announced the receipt on ... indicating that, according to the,Company,s financial statements for ...
... to the NASDAQ Capital Market, NEW YORK, ... ; LSE: XTL; TASE: XTL), a biopharmaceutical company,engaged ... the treatment of unmet medical needs, particularly,neuropathic pain ... August 23,2007, of a NASDAQ Staff Deficiency Letter ...
... CITY, Aug. 27 ARUP Laboratories, a national,clinical ... in,innovative laboratory research and development, announced today that ... Premier Purchasing,Partners, L.P., one of the nation,s largest ... The agreement extends a previous,contract between ARUP and ...
Cached Biology Technology:XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 3XTL Receives Staff Letter From NASDAQ 2XTL Receives Staff Letter From NASDAQ 3ARUP Laboratories and Premier Extend Contract for Reference Laboratory Testing Services 2
... Mouse L1210 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
... P815 cells were cultured in DMEM and harvested ... order to keep the antigens in their native ... cells are arrayed on a 12-well (5 mm) ... treated to enhance cellular attachment and to minimize ...
...
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
Biology Products: