Navigation Links
High blood pressure takes big toll on small filtering units of the kidney
Date:9/19/2008

Take a kidney out of the body and it still knows how to filter toxins from the blood.

But all bets are off in the face of high blood pressure.

"How does the kidney know how to do it and why does it break in hypertension?" says Dr. Edward W. Inscho, physiologist in the Medical College of Georgia Schools of Medicine and Graduate Studies.

The kidneys filter about 200 quarts of plasma daily, eliminating about two quarts of waste product and extra water as urine, according to the National Institute of Diabetes and Digestive and Kidney Diseases. But the complete physiology remains a mystery.

He challenged colleagues to fill in important blanks in how this process works normally and how to make it work better in disease during the Sept. 19 Lewis K. Dahl Memorial Lecture at the 62nd High Blood Pressure Research Conference and Workshop in Atlanta.

One thing is clear: Hypertension takes a serious toll on the kidneys and damaged kidneys worsen hypertension. Dr. Inscho believes the kidneys' million hard-working filters, or glomeruli, are direct victims of high pressure. His research focuses on the minute arteries, or arterioles, that feed blood into each of them. These afferent arterioles are responsible for keeping blood pressure at a comfortable 60 mmHg inside glomeruli. At a healthy blood pressure of 120/80 mmHg, blood enters the artery at a mean pressure of 100 mmHg, but higher pressures mean the arterioles must work even harder to reach the 60 mmHg target. They seem up to the task at least initially, contracting to make it harder for blood to pass and reducing pressure in the process. "We want to know how it does that," Dr. Inscho says as he watches the near instantaneous contraction.

He thinks he may at least know the messenger. The first reaction to high pressure actually is for the small vessel to stretch. That stretch prompts smooth muscle cells on the vessel wall to release ATP, a common molecule known
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. High blood pressure, low energy -- a recipe for heart failure
2. Right breakfast bread keeps blood sugar in check all day
3. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
4. Folic acid lowers blood arsenic levels, according to Mailman School of Public Health study
5. Folic acid lowers blood arsenic levels in Bangladesh
6. Study reveals a key to blood vessel growth and possible drug target
7. Expecting an afternoon nap can reduce blood pressure
8. MIT: blood may help us think
9. Immune cells promote blood vessel formation in mouse endometriosis
10. Elevated nitric oxide in blood is key to high altitude function for Tibetans
11. Fine-tuning lasers to destroy blood-borne diseases like AIDS
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High blood pressure takes big toll on small filtering units of the kidney
(Date:9/30/2014)... 30, 2014 Winners of The Economist,s prestigious ... scheduled to take place at the JW Marriott Hong Kong on ... winners will share their experiences and the lessons those hold for ... proven innovation over the past decade, will be presented at a ... the summit. It will be the first time the ceremony has ...
(Date:9/29/2014)... tar tended to be lower for smokers of slim ... nicotine tended to be lower. , Slim cigarettes are ... around the world. Previous studies have shown that the ... these cigarettes are lower than those in regular cigarettes. ... are not necessarily linked to a reduced exposure to ...
(Date:9/29/2014)... Monday, September 29: Between 1970 and 2010 ... around the globe dropped 52 percent, says the ... Wildlife Fund (WWF). This biodiversity loss occurs disproportionately ... use of high-income countries. , In addition to ... data point to other warning signs about the ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Slim cigarette smokers not exposed to more harmful chemicals 2Half of global wildlife lost, says new WWF report 2
... mighty animal sounds are all around us. In a few ... discussed and heard at the largest meeting ever devoted to ... Monday June 30 through Friday July 4 at the Palais ... one dimension of Acoustics ,08 Paris. It is the field ...
... engineer who has developed optical technology shown to be ... received a $7.5 million grant over five years from ... that potentially could become a routine colon cancer screening ... cancer is the second-leading cause of cancer deaths in ...
... 25, 2008 An authority on the quality ... consumers and municipal water supply systems, including unexpected ... first of a special series of podcasts from ... scientific society. Marc Edwards, Ph.D., notes that ...
Cached Biology News:Killer whales, blind bats, discriminating dolphins, mating birds 2Killer whales, blind bats, discriminating dolphins, mating birds 3Killer whales, blind bats, discriminating dolphins, mating birds 4Killer whales, blind bats, discriminating dolphins, mating birds 5Killer whales, blind bats, discriminating dolphins, mating birds 6Killer whales, blind bats, discriminating dolphins, mating birds 7Killer whales, blind bats, discriminating dolphins, mating birds 8Killer whales, blind bats, discriminating dolphins, mating birds 9Killer whales, blind bats, discriminating dolphins, mating birds 10Killer whales, blind bats, discriminating dolphins, mating birds 11Killer whales, blind bats, discriminating dolphins, mating birds 12Killer whales, blind bats, discriminating dolphins, mating birds 13Killer whales, blind bats, discriminating dolphins, mating birds 14NCI grant launches clinical trials for colon cancer screening 2NCI grant launches clinical trials for colon cancer screening 3Global Challenges/Chemistry Solutions debuts with focus on drinking water 2
(Date:10/1/2014)... WARRINGTON, Pa. , Oct. 1, 2014 /PRNewswire/ ... the Company has been awarded a Phase II ... up to $3.0 million from the National Institute ... National Institutes of Health (NIH) to support the ... surfactant as a medical countermeasure to mitigate acute ...
(Date:10/1/2014)... Md. , Oct. 1, 2014  Spherix ... to the fostering and monetization of intellectual property, ... litigation against VTech and Uniden in the U.S. ... Texas has been rescheduled for ... for October 2, 2014.  The Court Order setting ...
(Date:10/1/2014)... The participants committed to not only ... their own time adjusting, tweaking and testing virtual models ... ready for judging. , “I enjoyed being involved as ... “The entries showed a commendable range exploring the ... the print medium and the creativity of the contestants.” ...
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
Breaking Biology Technology:Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Array Architects Challenges Staff to Create with 3D Printer 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3
... , , PRINCETON, N.J., July 24 ... companies from around the world who gather at InformexUSA 2010 will ... past, allowing them to connect more precisely with others in their ... The show opens February 16, 2010 in San Francisco, with a ...
... , SILVER SPRING, Md., July 24 ... that it will release its 2009 second quarter financial results ... , United Therapeutics Corporation will host ... a.m. Eastern Time. The teleconference is accessible by dialing ...
... ... offers Fetal Bovine Serum (FBS) originating from abattoirs located in the US, ... treatments such as heat inactivation, dialysis, or gamma irradiation are available as ... FBS for embryonic stem cell research. Each FBS order includes a ...
Cached Biology Technology:Informex Rebrands Into Separate Pharmaceutical and Specialty Chemical Segments to Better Serve Exhibitors and Attendees 2Informex Rebrands Into Separate Pharmaceutical and Specialty Chemical Segments to Better Serve Exhibitors and Attendees 3Spectrum Announces Fetal Bovine Serum Product Line 2
... exchange media are hydrophilic, ... binding capacity. The UNOsphere ... strong cation exchanger with ... 120 micrometers. Fully supported ...
... This CLS number is a new ... Cornings product number. If showing no ... old Sigma-Aldrich number (Z71,487-9) or contact ... clarifier: centre neck 100 mm, No. ...
Packaging: 6 bottles for 1 l ready-to-use-solution ID clarifier: ready-to-use solution ...
... S-X media are neutral, porous ... exclusion chromatography of lipophilic polymers ... organic eluents. The beads are ... carbon tetrachloride, dimethylformamide, ketones, aromatics, ...
Biology Products: