Navigation Links
Herpesviruses undercover
Date:6/6/2014

This news release is available in German.

The Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus that can cause multiple forms of cancer, establishes lifelong infections within the body. To do so the virus has to find a way to modulate the immune system of its host.

Intruders are usually fought off immediately by an antiviral immune response that is triggered by sensors including the toll-like receptors (TLR)," says HZI researcher Dr. Kendra Bussey, author of the study that was published in the "Journal of Virology". Toll-like receptors detect the virus by binding to structures on the viral surface or the viral DNA, and trigger a signal chain that in the end leads to an antiviral immune response. Ideally this means that the pathogen is eliminated immediately. This mechanism, however, does not seem to work for KSHV and other gammaherpesviruses, as those can remain within the body for a long time.

How the virus does this was unknown until now. The scientists from the HZI research group "Viral Immune Modulation" under the leadership of Prof. Melanie Brinkmann have now been able to show that the virus is actively preventing activation of the innate immune system through Toll-like receptors.

It has yet to be established how exactly and in which part of the Toll-like receptor function is disturbed. This is one of the leverage points for future research: "The better we understand how the virus protects itself from attacks by the immune system, the better we can use this knowledge to fight infections," Brinkmann says.

This may lead to the development of new drugs against gammaherpesviruses. "Those agents could actively protect the immune system and prevent viruses from winning the fight against it," says Bussey. "However, this is still a long way off."


'/>"/>

Contact: Rebecca Winkels
rebecca.winkels@helmholtz-hzi.de
49-531-618-11403
Helmholtz Centre for Infection Research
Source:Eurekalert  

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Herpesviruses undercover
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Liquid Biotech USA , Inc. ... Research Agreement with The University of Pennsylvania ("PENN") ... patients.  The funding will be used to assess ... outcomes in cancer patients undergoing a variety of ... to support the design of a therapeutic, decision-making ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of 8.5 ... end machines that use the more unconventional z-dimension of 20mm. Z-dimension or ... the cuvette holder. , FireflySci has developed several Agilent flow cell product lines ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, ... microbial test has received AOAC Research Institute approval 061601. , “This is another ... year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel ...
Breaking Biology Technology: