Navigation Links
Herpes virus link to complications in pregnancy
Date:2/17/2008

Researchers at Adelaide's Women's & Children's Hospital and the University of Adelaide, Australia, have made a world-first discovery that links viral infection with high blood pressure during pregnancy and pre-term birth.

The research findings, published in the British Journal of Obstetrics & Gynaecology, are a major step forward in unravelling the mystery of the cause of high blood pressure in pregnancy.

The research has been conducted by the South Australian Cerebral Palsy Research Group, based in the University of Adelaide's School of Paediatrics & Reproductive Health and the Women's and Children's Hospital Microbiology & Infectious Diseases Department.

Their work demonstrates, for the first time, that exposure to viral infection -- especially viruses of the herpes group -- may be associated with pregnancy-induced hypertensive disease (pre-eclampsia) and also with pre-term birth.

The research discovered the presence of viral nucleic acid in heel-prick blood samples from 1326 newborn babies, taken over a 10-year period. More than 400 of these babies were diagnosed with cerebral palsy.

"This is an exciting finding and further studies are now required to look at the link between viral exposure in pregnancy and genetic susceptibility to adverse pregnancy outcomes, such as high blood pressure, premature delivery and cerebral palsy," says Professor Alastair MacLennan, leader of the research group.

Pregnancy hypertension (high blood pressure) occurs in up to 10% of first pregnancies throughout the developed world, such as in the UK, the United States and Australia. When untreated, it can lead to uncontrolled epileptic fits of eclampsia with loss of baby and mother. It is a common cause of maternal death in Third World countries.

The cause of high blood pressure in pregnancy has been an enigma for decades and a holy grail for many researchers.

The Adelaide research group has already demonstrated a link between viral infection in pregnancy, genetic mutations in genes controlling inflammatory and blood clotting processes, and the development of cerebral palsy.

The group has also found an association between several hereditary gene mutations with changes in inflammatory proteins that may cause dysfunction and constriction of the blood vessels of the placenta and brain, thus causing the rise in blood pressure in pregnancy. If not controlled, this can be lethal.

"We are just beginning to understand the interaction and importance of exposure to viruses and genetic susceptibility to infection both in pregnancy and the newborn," says Associate Professor Paul Goldwater, the virologist of the team.


'/>"/>

Contact: Professor Alastair MacLennan
alastair.maclennan@adelaide.edu.au
61-881-617-619
University of Adelaide
Source:Eurekalert

Related biology news :

1. Penn researchers shine the light of venus to learn how the herpes virus invades cells
2. The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
3. Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
4. Poxvirus potency uncovered in new atomic map
5. Great apes endangered by human viruses
6. Ebola virus disarmed by excising a single gene
7. Yellowstone viruses jump between hot pools
8. Iowa State researchers develop technology for early detection of viruses
9. Study proposes new theory of how viruses may contribute to cancer
10. West Nile virus spread through nerve cells linked to serious complication
11. Feline virus, antiviral drug studied to understand drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
(Date:3/10/2016)... , March 10, 2016 ... market research report "Identity and Access Management Market by ... Compliance, and Governance), by Organization Size, by Deployment, by ... published by MarketsandMarkets, The market is estimated to grow ... Billion by 2020, at a Compound Annual Growth Rate ...
(Date:3/9/2016)... Nigeria . Recently, ... 23,000 public service employees either did not exist with ... unlawfully.    --> Nigeria . ... than 23,000 public service employees either did not exist ... salary unlawfully.    --> DERMALOG, the biometrics ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... and ongoing support for Connecticut's innovative, growing companies, today announced the launch of ... and financial technology (fintech) companies. , “VentureClash looks to attract the ...
(Date:4/27/2016)... ... ... Cambridge Semantics, the leading provider of Smart Data analytic and data ... to The Silicon Review’s “20 Fastest Growing Big Data Companies of 2016.” , ... of end users facing some of the most complex data challenges in the industry,” ...
(Date:4/27/2016)... , April 27, 2016 ... (CSE: NSK) (OTCPink: NSKQB) ( Frankfurt ... an ihre Pressemitteilung vom 13. August 2015 die ... ihre Finanzen um zusätzliche 200.000.000 Einheiten auf 400.000.000 ... Dollar zu bringen. Davon wurden 157.900.000 Einheiten mit ...
(Date:4/27/2016)... Baltimore, MD (PRWEB) , ... April 27, 2016 ... ... appointed Greg Lamka, PhD to its Scientific Advisory Board. Dr. Lamka will assist ... of plant pathogen detection. , PathSensors deploys the CANARY® test platform for ...
Breaking Biology Technology: