Navigation Links
Herpes virus: To vaccinate or not to vaccinate
Date:2/12/2009

Saranac Lake, N.Y., February 12, 2009--Dr. Marcia Blackman and her research team at the Trudeau Institute have followed up on an intriguing report published in the journal Nature in May 2007 by Dr. Herbert Virgin, et al., showing that mice persistently infected with certain forms of herpesvirus, which can establish lifelong latent infections, are resistant to infection with bacterial pathogens.

Although herpesvirus infections are generally considered undesirable and can be associated with declining immune function in the elderly or the development of a variety of tumors later in life, the Virgin report raised the unexpected possibility that they may also be beneficial.

Dr. Blackman's research has now confirmed Dr. Virgin's findings, but with some further refinements about herpes' roles in preventing other infections: "We discovered that the effect of herpesvirus infection is transient, lasting only a few months. Interestingly, although the effect was shown by the Virgin group to be dependent on establishing a latent infection, it wanes despite lifelong latency."

Recognizing that her data had implications for the interpretation of Dr. Virgin's data, Dr. Blackman shared her findings with the Virgin group prior to publication. This led to an interesting exchange between the two labs in the form of letters to the editor regarding the potential benefits of a transient protective effect. The letters will be published concurrently with Blackman's data in the February issue of Viral Immunology (Vol. 22, No.1). The scientists agree that even short-acting protection, especially during childhood, might have long-lasting implications in terms of survival rates.

A major point of discussion between the two groups concerned the implications of such research for the development of vaccines against herpesvirus infections. Dr. Virgin suggested that "decreased infection may be associated with unintended negative consequences for vaccinated individuals." In response, Dr. Blackman argues that possible transient protective effects did not outweigh the already recognized pathological consequences of herpesvirus infection. Both groups agreed that the protective effects of herpesvirus infections merit further study.

Importantly, both groups hope their observations will stimulate epidemiological and clinical studies to determine whether herpesvirus infections really protect humans against bacterial diseases.


'/>"/>

Contact: Brian Turner
bturner@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert  

Related biology news :

1. Penn researchers shine the light of venus to learn how the herpes virus invades cells
2. Herpes virus link to complications in pregnancy
3. Herpes drug inhibits HIV in patients infected with both viruses
4. Potential new herpes therapy studied
5. Prostate cancer: Watchful wait or vaccinate?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Herpes virus: To vaccinate or not to vaccinate
(Date:4/13/2017)... -- According to a new market research report "Consumer IAM ... and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global ... grow from USD 14.30 Billion in 2017 to USD 31.75 Billion by ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:7/25/2017)... New Canaan, CT (PRWEB) , ... July 25, ... ... developing sustainable products that enhance the microbiome and improve efficiency of livestock farming ... today announced that it has licensed additional intellectual property from Cornell University. ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering and Computer Science ... Award winner. Presented annually, the award recognizes an individual who has made ...
(Date:7/20/2017)... ... 20, 2017 , ... Corista, a leader in integrated pathology ... July 25, during the Association of Pathology Chairs’ Jubilee Meeting in Washington, DC. ... Associate Director of Pathology Informatics, will present “The Digital Pathology Experience at Johns ...
(Date:7/18/2017)... ... , ... Sourcing custom glass or quartz parts can be a daunting task. ... execute your job can take many hours of emails, phone calls and on-line research. ... showcase the company’s capabilities and core custom categories, and enables you to start the ...
Breaking Biology Technology: