Navigation Links
Herpes-loaded stem cells used to kill brain tumors
Date:5/16/2014

hat MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking," he continued. "So, we loaded MSCs with oncolytic herpes virus and encapsulated these cells in biocompatible gels and applied the gels directly onto the adjacent tissue after debulking. We then compared the efficacy of virus-loaded, encapsulated MSCs versus direct injection of the virus into the cavity of the debulked tumors."

Using imaging proteins to watch in real time how the virus combated the cancer, Shah's team noticed that the gel kept the stem cells alive longer, which allowed the virus to replicate and kill any residual cancer cells that were not cut out during the debulking surgery. This translated into a higher survival rate for mice that received the gel-encapsulated stem cells.

"They survived because the virus doesn't get washed out by the cerebrospinal fluid that fills the cavity," Shah said. "Previous studies that have injected the virus directly into the resection cavity did not follow the fate of the virus in the cavity. However, our imaging and side-by-side comparison studies showed that the naked virus rarely infects the residual tumor cells. This could give us insight into why the results from clinical trials with oncolytic viruses alone were modest."

The study also addressed another weakness of cancer-killing viruses, which is that not all brain tumors are susceptible to the therapy. The researchers' solution was to engineer oncolytic herpes viruses to express an additional tumor-killing agent, called TRAIL. Again, using mouse models of glioblastomathis time created from brain tumor cells that were resistant to the herpes virusthe therapy led to increased animal survival.

"Our approach can overcome problems associated with current clinical procedures," Shah said. "The work will have direct implications for designing clinical trials using oncolytic viruses, not only for brain tumors, but fo
'/>"/>

Contact: Joseph Caputo
joseph_caputo@harvard.edu
617-496-1491
Harvard University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Herpes-loaded stem cells used to kill brain tumors
(Date:11/7/2014)... Dr. Debra Auguste, associate professor, biomedical engineering, in ... College of New York, have identified a molecule ... of the most aggressive forms of breast cancer. ... high mortality rate owing to aggressive proliferation and ... However, Professor Auguste,s team, discovered the overexpression of ...
(Date:11/6/2014)... that predator runs so fast that it essentially blinds itself. ... fastest creature on Earth. Some of these half-inch-long beetles cover ... per hour). The fastest human can do about five body ... a person would have to hit 480 miles per hour. ... speeds, everything becomes a blur. They can,t gather enough light ...
(Date:11/4/2014)... Nov. 5, 2014 – University of Utah engineers developed ... help jet fuel produce electricity without needing to ignite ... to power portable electronics, off-grid power and sensors. , ... in the American Chemical Society journal ACS Catalysis ... a chemical reaction between a fuel and an oxygen-rich ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2Jet-fueled electricity at room temperature 2
... An international team led by scientists at The ... and Albert Einstein College of Medicine of Yeshiva University ... attacks the tuberculosis (TB) bacterium in two different ways. ... one of the major global health crises of our ...
... professors in Wayne State University,s Department of Physics kicked ... for Undergraduates (REU) program. This program aims to give ... and in particle and nuclear physics. According ... State,s College of Liberal of Arts, principal investigator and ...
... foundations with more modern elements. Using this same approachbut ... Dietrich School of Arts and Sciences have designed a ... storage, and gas transport more efficient and at a ... issue of the Journal of the American Chemical ...
Cached Biology News:New compound excels at killing persistent and drug-resistant tuberculosis 2New compound excels at killing persistent and drug-resistant tuberculosis 3New compound excels at killing persistent and drug-resistant tuberculosis 4Wayne State welcomes undergraduates from around the US for physics research experience 2'Chemical architects' build materials with potential applications in drug delivery and gas storage 2
(Date:11/27/2014)... The Europe Thermal Protective Clothing market report ... revenue forecasts. It estimates the market to reach ... of 7.5%, from 2013 to 2018. , Browse ... Clothing market report for a glimpse of the ... tables and figures. , http://www.micromarketmonitor.com/market/europe-thermal-protective-clothing-5957050557.html , ...
(Date:11/27/2014)... USA (PRWEB) November 26, 2014 Biomedical ... accuracy, additive systems to enable 3D manufacture at the ... road conditions are among finalists in nine categories for ... The awards are sponsored by SPIE, the international ... Media . , Winners will be announced by industry ...
(Date:11/26/2014)... Chicago, IL (PRWEB) November 26, 2014 ... is giving customers a bevy of last-minute Thanksgiving ... coupon codes and offers across all product lines this ... Thanksgiving. , Thanksgiving, Black Friday, and Cyber Monday ... expressing its' own thanks to both loyal customers and ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 The ... City’s award-winning technology innovation centers, announced today that ... closing on December 1st. “Do you have a ... so, I want to know about it. AccelerateBaltimore ... idea to product in just 13 weeks.” ...
Breaking Biology Technology:The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 2The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 3Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
... Coalition,s Annual Meeting, FREMONT, Calif., Sept. 8 ... announced today that a,team of scientists at Stanford University ... at the Annual General Meeting of the,PAD Coalition. Led ... Eric T.,Fung, Chief Scientific Officer at Vermillion, Inc., the ...
... Sept. 8 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, ... enrolment in a Phase 2 clinical trial using ... in patients with advanced head and neck cancers. ... Cancer Therapy & Research Center,(CTRC) at The University ...
... International,Inc. (Nasdaq: CHDX ), a leading independent American provider ... China, today,announced that the Company will appear at the following ... held at the Grand Hyatt Hotel ... available for this event. -- ...
Cached Biology Technology:Vermillion and Stanford Scientists Receive 'Best Research Award' From the PAD Coalition 2Vermillion and Stanford Scientists Receive 'Best Research Award' From the PAD Coalition 3Oncolytics Biotech Inc. Starts Patient Enrolment in U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 2Oncolytics Biotech Inc. Starts Patient Enrolment in U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 3Chindex International, Inc. Announces Appearances at Upcoming Investor Conferences 2Chindex International, Inc. Announces Appearances at Upcoming Investor Conferences 3
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
Black Polypropylene 384 Round Well Plate 70/Box...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
... Synucleins are small, soluble proteins expressed ... tumors. The family includes three known proteins: ... The alpha and beta synuclein proteins are ... are seen mainly in presynaptic terminals. ...
Biology Products: