Navigation Links
Herpes drug inhibits HIV in patients infected with both viruses
Date:9/15/2008

This release is available in French.

Researchers at the U.S. National Institutes of Health (NIH), McGill University and other institutions have discovered how a simple antiviral drug developed decades ago suppresses HIV in patients who are also infected with herpes. Their study was published in the Sept. 11 issue of the journal Cell Host and Microbe.

An NIH research team led by Dr. Leonid Margolis made the initial discovery, while Dr. Matthias Gotte, Associate Professor in Biochemical Virology at McGill's Department of Microbiology and Immunology, along with colleagues at Emory University, helped explain the precise molecular mechanisms.

According to Dr. Gotte, HIV/herpes co-infection rates are very high and carry significant health burdens for those patients who are already coping with HIV.

"In co-infected individuals, HIV disease progression is enhanced by the presence of herpes," he explained. "Why this is the case is not clear, but there's a lot of evidence for it. Moreover, if you're infected with HIV and herpes, it makes it easier for you to transmit HIV to other people. And if you're infected with herpes alone, it makes it easier for you to acquire HIV."

Though it was long-believed that acyclovir was an ineffective drug against HIV, it was often prescribed to co-infected patients in the hope of indirectly treating HIV by reducing the herpes load. Surprisingly, the NIH team discovered that in the presence of herpes virus HHV-6, acyclovir actually attacks HIV directly and is able to suppress its reproduction.

Acyclovir is a "prodrug," which is converted into its active form only after it is administered to a patient. The research team demonstrated that the herpes virus contains an enzyme not present in HIV and it is this enzyme that converts acyclovir into a compound capable of attacking in HIV. Acycl
'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Herpes virus link to complications in pregnancy
2. Penn researchers shine the light of venus to learn how the herpes virus invades cells
3. A compound extracted from olives inhibits cancer cells growth and prevents their appearance
4. Majority of osteoporosis patients not receiving calcium and vitamin D with treatment
5. A home early warning system for cardiac patients
6. New sensory devices will aid Parkinsons and stroke patients
7. Unlocking mystery of why dopamine freezes Parkinsons patients
8. CMV infections affect more than just patients with compromised immune systems, researchers find
9. Smothered genes combine with mutations to yield poor outcome in cancer patients
10. Cross fire from the brain makes patients tremble
11. New treatment approach promising for lymphoma patients in the developing world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... visible in in this image of the Para and ... were most likely intentionally set in order to deforest ... or stand of trees where the land is thereafter ... conversion of forestland to farms, ranches, or urban use. ... of the Amazon Rainforest in the middle of the ...
(Date:8/20/2014)... discovered that acral melanomas the rare type of skin ... genetically distinct from other more common types of skin cancer, ... journal Pigment Cell & Melanoma Research . , Acral ... of the feet, nail-beds and other hairless parts of the ... caused by UV damage from the sun. , The team, ...
(Date:8/20/2014)... Feng has built upon a National Science Foundation (NSF) ... program, and synergistically complemented it with subsequent collaborative grants, ... on "big computing" for mini-drones and a $1 million ... on "big data" for the life sciences. , As ... grant, he was able to tell a much larger, ...
Breaking Biology News(10 mins):Scientists learn more about rare skin cancer that killed Bob Marley 2The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4
... measly angstrom's difference in diameter is a road-closed sign: ... water-molecule-sized sports car, say scientists at the University of ... a class of proteins that form trans-membrane channels in ... for water movement between the cell and its environment. ...
... management is the key to regulating cell volume says Dutch ... water by the plasma membrane of animal and human cells. ... balance between water uptake and secretion by the cell plasma ... salt concentrations in and around the cell. Exactly how this ...
... Johns Hopkins who has spent nearly three decades studying ... fever warns that the first widespread outbreak of the ... sign of how humans can inadvertently help spread infectious ... to be published in The New England Journal of ...
Cached Biology News:Cells direct membrane traffic by channel width 2Water management in cells 2Infectious disease expert warns of spread of Rocky Mountain spotted fever 2Infectious disease expert warns of spread of Rocky Mountain spotted fever 3
(Date:8/19/2014)... 2014 Robin Williams’ passing is a ... on an individual. Symptoms range from slowness of ... swallowing and severe depression. Parkinson’s disease progressively gets ... dopamine producing neurons of the brain. As these ... slowly and progressively gets worse, they look for options. ...
(Date:8/19/2014)... 2014 Research and Markets ... "Spectroscopy Equipment and Accessories - Global ... offering. This report analyzes ... Accessories in US$ Thousands by the following ... Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) Spectrometers, ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 In November 2012, ... Benefit Risk Evaluation Report (PBRER) in a new PSUR – ... post-authorization safety benefit-risk profile of a drug. Adopted in many ... , Present a comprehensive and critical analysis of ... , Highlight any new evidence of the potential ...
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics Inc. ... today reported results of its Oral Amphotericin B ... reservoirs.  The study, conducted by ImmuneCarta®, the immune ... vitro effectiveness of Oral Amp B in ... in individuals despite intensive treatment with antiretroviral therapy. ...
Breaking Biology Technology:As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3
... Inc. (Nasdaq: SGMO ) announced today that Edward ... the progress of,Sangamo,s ZFP Therapeutic development programs and an ... on Tuesday, August 5, 2008,at the BMO Capital Markets ... The presentation will be webcast live and may be ...
... - Federal, state, and,local forensic crime labs received ... 2005, according to a report by the Justice,Department,s ... for a variety of forensic services, such as ... An estimated 359,000 cases were backlogged (or not ...
... C. Powell, former,President and Chief Operating Officer of ... Nerites Corporation., Under Powell,s guidance, SurModics developed ... to commercialize products.,Powell joined SurModics in 1987 as ... the company,s transition from a diagnostics kit,manufacturer to ...
Cached Biology Technology:Sangamo BioSciences to Present at the BMO Capital Markets Focus on Healthcare Conference 2Crime Labs Received an Estimated 2.7 Million Cases in 2005 2Crime Labs Received an Estimated 2.7 Million Cases in 2005 3James C. Powell Joins Nerites Board of Directors 2
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... powerful solution for all plate washing needs in ... ,The PW 384 provides an excellent solution ... Drug Discovery (Assay development, Screening or Lead Optimization) ... ,The PW 384 has set a standard ...
... a compact benchtop and stackable multi-function ... with a large display screen to ... Air circulation inside to evenly distribute ... be easily calibrated from the microprocessor ...
... siTrio siRNA --- a cocktail of 3 ... of interestis our most popular product. The ... 75% knockdown of your target gene when ... for transfection and confirmation of optimal transfection ...
Biology Products: