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Herding cancer cells to their death
Date:6/20/2013

rapy that addresses cancer cell heterogeneity, that eradicates the tendency of cancer cells to become invasive, that works on cells that are resistant to other therapies and that targets only the cancer cells and not any others. I think we've ticked all those boxes."

"By inducing melanoma to differentiate using an old chemotherapy drug, Saez-Ayala and colleagues took advantage of a protein expressed at high levels as a consequence of that differentiation to turn a molecule they have designed into a prolific melanoma killer," said Antoni Ribas, MD, PhD, Professor of Medicine at the University of California Los Angeles and the Jonsson Comprehensive Cancer Center in Los Angeles. "Based on their preclinical data, I believe that this two-step approach may have promise for treating melanoma."

Still, Goding notes, cancer cells are so mutable that some melanoma cells will inevitably develop resistance to the novel therapy. So he expects that, aside from showing that the strategy works in patients, future research will have to show that it can be combined with other cancer therapies to get around such resistance. "That's how we should be thinking about cancer therapy," he says. "The complexity of the disease is such that any one therapy probably won't work on its own. But if you give complementary therapies that work in completely different ways, then I think you have a chance against this disease."


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Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

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