Navigation Links
Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer
Date:4/18/2008

Berlin, Germany: Women with a particularly aggressive form of breast cancer seem to do better if they are treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab (Herceptin) before and after surgery, according to results from the largest multi-centre trial to investigate this treatment.

Professor Michael Untch told the 6th European Breast Cancer Conference (EBCC-6) in Berlin today (Friday) that the women in the trial did not suffer from any serious side effects of the treatment such as severe heart problems. These results are very challenging, as both trastuzumab and anthracyclines are associated with cardiac toxicity.

Prof Untch said: When we started this trial it was considered very courageous to give patients anthracyclines plus trastuzumab, but we wanted to expose patients to trastuzumab for as long as possible before surgery to make it as effective as possible. To minimise the risk, we excluded patients with any previous heart problems and excluded patients with ejection fractions of below 55%. However, our results showed no increase in toxicity for the combination chemotherapy plus trastuzumab compared with chemotherapy alone. There were no cases of congestive heart failure or cardiac-related deaths, and other cardiac-related symptoms were not severe. The combination chemotherapy plus trastuzumab proved to be the most effective combination, but, at the same time, we have to keep an eye on the heart. Therefore, cardiac monitoring every three months is a must for patients treated with this regimen.

A total of 1510 breast cancer patients were recruited to the GeparQuattro trial between 2006-2007; 453 of them had tumours that over-expressed the HER2 receptor (a particularly aggressive form of the disease). Before surgery they received four cycles of epirubicin/cyclophosphamide (EC) and were then randomised to receive either four cycles of docetaxel (D) or four cycles of D-capec
'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC health news: molecular pathway may predict chemotherapy effectiveness
2. A search for protection against chemotherapy cardiotoxicity
3. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
4. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
5. Exercise improves thinking, reduces diabetes risk in overweight children
6. Endobronchial valve significantly improves emphysema
7. Teamwork improves learning and career success
8. New clinical data shows chromium picolinate improves cognitive function
9. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
10. Key to out-of-control immune response in lung injury found
11. Flies can turn off their immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... news release is available in German . ... get new information about the metabolism of plants can ... However, Erich Kombrink from the Max Planck Institute for ... the University of Duisburg-Essen adopt a different approach. They ... metabolic process like brake pads and prevent the downstream ...
(Date:8/19/2014)... Daylight was breaking over the central Pacific and ... about a dozen scientists strategized for the day ahead. ... to collect water samples around the southern Line Islands, ... gizmos and delicate machinery strewn throughout the 158-foot research ... research group to bring a DNA sequencer out into ...
(Date:8/18/2014)... , August 19, 2014 ... Ready biometric authentication in smart devices  ... (TEEs) for smart devices, and Fingerprint Cards AB ... availability of FIDO Ready™ secure biometric authentication on ... FPCs touch fingerprint sensors (FPC1020, FPC1021 and FPC1150) ...
Breaking Biology News(10 mins):Researchers block plant hormone 2Researchers block plant hormone 3Sequencing at sea 2Sequencing at sea 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 2Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 4
... LOS ANGELES In research that one day may lead to ... disease, investigators at Childrens Hospital Los Angeles have identified PDGF ... epicardial cells, one type of cell that surrounds heart muscle ... September 21 in advance of the publication of the ...
... COLUMBIA, Mo. A cancer drug that benefits people ... teaching professor of oncology at the MU College of ... that examines the efficacy of Attaxol in dogs with ... by CritiTech, a Lawrence, Kan. drug development company. ...
... long encouraged by doctors as a supplement to support heart ... and colon cancer in mice in research led by Michigan ... Cancer Research . Jenifer Fenton, a food science and ... establishing a dose limit for docosahexaenoic acid (DHA), one of ...
Cached Biology News:Childrens Hospital LA discovers growth factor essential to epicardial cell function 2MU College of Veterinary Medicine to study efficacy of cancer drug in dogs 2Fish oil linked to increased risk of colon cancer in mice 2
(Date:8/18/2014)... (PRWEB) August 19, 2014 2014 ... Industryā€¯ is a professional and in-depth research report ... basic Linalool information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:8/18/2014)... 18, 2014 BioElectronics Corporation (OTC ... medical devices said that its EVP Dr. ... CEOLIVE.TV as part of its Executive Interview ... available at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel ... investors the unique advantages of BioElectronics patented ...
(Date:8/18/2014)... Global HIV Infection Drug Market and ... Reportstack. The rate of HIV infection and the number of ... at a positive rate across the globe. It has been ... 2005 to 1.5 in 2013, with the rates for children ... changes in the infection rates has been the improved access ...
(Date:8/18/2014)... -- TNI BioTech, Inc. (OTC-BB: TNIB) ("we" or the ... of innovative therapies for autoimmune diseases in emerging nations, ... notice of TNI BioTech,s annual meeting of September 4, ... Griffin , founder and CEO of TNI BioTech Inc. ... the Annual Meeting. On behalf of our employees and ...
Breaking Biology Technology:Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4
... 2010 , , , ... and Safety Endpoints , , , ... European Medicines Agency in,2010 , , , ... focused on,women,s reproductive medicine, announces positive Phase III data from its,second pivotal study (PEARL I) for its ...
... PARIS , June 2 Cellectis ... Frederic Paques, PhD, Chief Scientific Officer, Julianne Smith , ... genome surgery, and Feng Zhang , PhD, Research Director ... results on meganucleases and genome surgery at the FASEB ...
... ... Council survey examines consumer attitudes toward food technology. , ... Washington, DC (Vocus) Junw 2, 2010 -- ... survey found that consumers support the use of food biotechnology when they consider its ...
Cached Biology Technology:PregLem Announces Positive Phase III Results for Esmya(TM) 2PregLem Announces Positive Phase III Results for Esmya(TM) 3PregLem Announces Positive Phase III Results for Esmya(TM) 4Cellectis to Present at the FASEB Summer Research Conference on Genome Engineering 2Cellectis to Present at the FASEB Summer Research Conference on Genome Engineering 3Interest in Environment & Sustainability Prevails in Food Technology Survey 2Interest in Environment & Sustainability Prevails in Food Technology Survey 3Interest in Environment & Sustainability Prevails in Food Technology Survey 4Interest in Environment & Sustainability Prevails in Food Technology Survey 5
... of large numbers of samples may be carried ... which requires minimum operator attention. System control ... and interface CE 4900. The elegant, powerful ... Windows XP and Windows 98 and 2000., The ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (F1676) or contact customer s...
... is a new product number, created ... If showing no availability yet, please ... (E6152) or contact customer service for ... diam. 11.25 6.40 in. ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: