Navigation Links
Hepatitis C virus may need enzyme's help to cause liver disease
Date:7/9/2008

PITTSBURGH, July 9 A key enzyme may explain how hepatitis C infection causes fatty liver a buildup of excess fat in the liver, which can lead to life-threatening diseases such as cirrhosis and liver cancer, report University of Pittsburgh Graduate School of Public Health and School of Medicine researchers.

The study, published in the July 9 online issue of Hepatology, shows that an enzyme known to play a major role in lipid production, fatty acid synthase (FAS), was highly elevated in human liver cells exposed to the hepatitis C virus. While preliminary, the research suggests that testing for elevated levels of FAS could help determine which patients with hepatitis C virus may go on to develop more serious, long-lasting health consequences brought on by fatty liver.

Nearly 200 million people worldwide are infected by hepatitis C, including 4 million Americans. Seventy percent of people with hepatitis C develop chronic liver disease, and the infection is the leading reason for liver transplantation in the United States.

Unlike hepatitis A and B, there is no vaccine to prevent hepatitis C infection. Since hepatitis C typically has no symptoms, many people do not know they have the infection until they develop signs of liver failure or fatty liver, sometimes decades after infection. The virus replicates and mutates quickly, helping it to evade discovery and attack by the immune system and allowing it to slowly wreak damage on the liver.

"Our study has provided new insight into how hepatitis C causes fatty liver. This has important implications for future studies and efforts to understand how the virus causes an increase in fatty acid levels that can lead to serious liver conditions," said Tianyi Wang, Ph.D., assistant professor, Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, and the study's lead author.

To identify possible proteins in the he
'/>"/>

Contact: Clare Collins
CollCX@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clearance of hepatitis C viral infection after liver transplantation
2. Who will recover spontaneously from hepatitis C virus infection
3. Possible hepatitis C vaccine
4. Eltrombopag effective for hepatitis C patients with low blood-platelet counts
5. Nucleonics initiates hepatitis B clinical trial with expressed interfering RNA therapeutic
6. New hope for hepatitis C sufferers
7. BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients
8. Features of replication suggest viruses have common themes, vulnerabilities
9. First all-African GM crop is resistant to maize streak virus
10. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
11. Gamma globulin effective in treating eye infections caused by adenoviruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 2014 Research and Markets , ... has announced the addition of the "Biometrics Market ... One major trend emerging in this ... technology, it is important to upgrade biometric solutions to ...
(Date:12/11/2014)... 10, 2014  That blood pressure plays a role in human ... the medical term for high blood pressure – was first ... inflatable cuff that,s used in measuring blood pressure was invented ... new about hypertension, its triggers and its effects. In fact, ...
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately need to ... site key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security company, launches ... the frustration that comes with usernames, passwords and PINs – ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... nanoparticles, tiny pieces of gold so small that they ... in electronics, healthcare products and as pharmaceuticals to fight ... the nanoparticles requires dangerous and extremely toxic chemicals. While ... of nanoparticles in the near future, researchers have been ...
... Can a road-trip across eastern North America, ancient ice sheets, ... trees? Julie Godbout and colleagues from the Universit Laval, ... Canada to collect samples from jack pine trees would shed ... genetics. About 20,000 years ago, ice sheets covered ...
... genetic material. Endogenous retroviruses (ERV) are those sequences derived ... that, being incorporated in the genome, are transmitted from ... the expression of ERV can benefit the host if ... the protection of the embryo. However, given its pathogenic ...
Cached Biology News:Cinnamon can replace harmful chemicals used to create nanoparticles 2Blast from the past: Jack pine genetics support a coastal glacial refugium 2Blast from the past: Jack pine genetics support a coastal glacial refugium 3Ph.D. thesis describes 35 hitherto unknown families of endogenous retroviruses 2
(Date:1/22/2015)... January 22, 2015 Eckert & Ziegler ... Spectrometry (AMS) services to the pharmaceutical and biotech industry, ... the company in the position of Director of Science ... broad and valuable experience in drug metabolism and bioanalysis ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2
... a developer of follow-on biologics and biopharmaceuticals, announced,today that ... Stewart Fourth Annual Growth Conference on Thursday, July 10, ... conference will take place at the Mandarin Oriental Hotel ... July 10. Insmed,s,presentation will be webcast live over the ...
... Inc.,(Nasdaq: ATSI ), manufacturer and marketer of ... has obtained new in vivo,data to support the ... Heart Valve., (Logo: http://www.newscom.com/cgi-bin/prnh/20040202/ATSILOGO ), ... in Lausanne, Switzerland,on May 4, 1992 by Professor ...
... July 8, 2008Biotech and pharmaceutical firms are developing ... the complicated drug discovery process, reports Genetic ... Most successful approaches rely on a combination of ... tools, according to an article in the July ...
Cached Biology Technology:Insmed to Present at Collins Stewart Fourth Annual Growth Conference 2ATS Medical Confirms Excellent Durability of the ATS Open Pivot Mechanical Heart Valve 2
Component in MasterPure™ Purification Kits...
Mouse monoclonal [TU-20] to beta III Tubulin (FITC) ( Abpromise for all tested applications). entrezGeneID: 10381 SwissProtID: Q13509...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Mouse anti-Insulin-Like-3 Class: Antibody Product Group: Adipokine and Obesity related...
Biology Products: