Navigation Links
Hepatitis C virus genotype 1 is most prevalent worldwide

In one of the largest prevalence studies to date, researchers from the U.K. provide national, regional, and global genotype prevalence estimates for the hepatitis C virus (HCV). Findings published in Hepatology, a journal of the American Association for the Study of Liver Diseases, indicate that genotype 1 is the most prevalent worldwide, with over 83 million patients infected of which one-third reside in East Asia. Genotype 3, at just over 54 million cases, is the next most prevalent, followed by genotypes 2, 4, 6, and 5.

Despite efforts to control HCV, it remains one of the most prevalent diseases globally, with up to 150 million patients living with chronic infection according to the World Health Organization (WHO). Previous research shows that chronic HCV leads to the development liver cirrhosis, hepatocellular carcinoma (HCC) or liver cancer, liver failure and death. WHO reports that 350,000 to 500,000 deaths each year are caused by liver diseases related to HCV.

"While the HCV infection rate is decreasing in developed countries, deaths from liver disease secondary to HCV will continue increasing over the next 20 years," explains lead co-author Dr. Jane Messina with the University of Oxford in the U.K. "Understanding the global trends in the genetic makeup of HCV is the focus of our study and imperative in developing new treatment strategies that may save millions of lives around the world."

Researchers identified 1,217 medical studies between 1989 (the year HCV was discovered) and 2013 that reported HCV genotypes. The data were then combined with HCV prevalence estimates from the WHO Global Burden of Disease project. Roughly 90% of the global population, representing 117 countries was included in this study.

Analysis shows that HCV genotype 1 is the most prevalent at 46% of all HCV cases, followed by genotype 3 at 30%; genotypes 2, 4, and 6 with a combined total of 23% and genotype 5 at less than 1%. Researchers highlight that genotypes 1 and 3 are most dominant regardless economic status, but found lower-income countries had larger concentrations of genotypes 4 and 5.

Dr. Eleanor Barnes with the University of Oxford adds: "The testing of new therapeutics is still dependent upon knowledge of viral genotype. Non-genotype 1 HCV, comprises more than half of all HCV cases. Our study provides evidence of genotype prevalence for specific countries and regions that will help improve access to new viral therapies to combat HCV."


Contact: Dawn Peters

Related biology news :

1. The search is on for a hepatitis B drug, thanks to a million dollars in NIH grants to SLU
2. New technique brings us closer to HIV and Hepatitis C vaccines
3. EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus
4. MassBiologics receives orphan drug status from FDA for hepatitis C treatment
5. Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
6. Transcription factor may protect against hepatic injury caused by hepatitis C and alcohol
7. Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
8. New Loyola study on hepatitis C virus entry factor
9. Vitamin D deficiency may help spread of hepatitis B throughout liver
10. New mouse viruses could aid hepatitis research
11. HIV sufferers need hepatitis safeguards
Post Your Comments:
Related Image:
Hepatitis C virus genotype 1 is most prevalent worldwide
(Date:11/10/2015)... 10, 2015 About signature ... helps to identify and verify the identity of ... as the secure and accurate method of authentication ... particular individual because each individual,s signature is highly ... when dynamic signature of an individual is compared ...
(Date:11/4/2015)... New York , November 4, 2015 ... to a new market report published by Transparency Market ... Share, Growth, Trends and Forecast 2015 - 2022", the global ... of US$ 30.3 bn by 2022. The market is ... the forecast period from 2015 to 2022. Rising security ...
(Date:10/29/2015)... 29, 2015  The J. Craig Venter Institute (JCVI) ... Synthesis and Biosecurity: Lessons Learned and Options for the ... and Human Services guidance for synthetic biology providers has ... --> --> Synthetic biology ... potential to pose unique biosecurity threats. It now is ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , England , November 26, 2015 ... Lightpoint Medical, an innovative medical device company specializing in imaging ... grant from the European Commission as part of the Horizon ... the company to carry out a large-scale clinical trial in ... -->      (Logo: , --> ...
(Date:11/25/2015)... , November 25, 2015 2 ... première fois les différences entre les souches bactériennes ... celles des êtres humains . Ces recherches ... et envisager la prise en charge efficace de ... diagnostiqués chez les chats .    --> ...
(Date:11/25/2015)... 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... and CEO of Neurocrine Biosciences, will be presenting at ... New York . .   ... approximately 5 minutes prior to the presentation to download ... presentation will be available on the website approximately one ...
(Date:11/25/2015)... , Nov. 25, 2015 Orexigen® Therapeutics, Inc. ... participate in a fireside chat discussion at the Piper ... York . The discussion is scheduled for Wednesday, ... .  A replay will be available for ... Stilwell  , Julie NormartVP, Corporate Communications and Business ...
Breaking Biology Technology: