Navigation Links
Heparin-like compounds inhibit breast cancer metastasis to bone
Date:5/21/2012

Researchers from VTT Technical Research Centre of Finland have in collaboration with the University of Turku, Indiana University and two Finnish companies, Biotie Therapies Corp. and Pharmatest Services Ltd, discovered a novel mechanism regulating the development of breast cancer bone metastases and showed that heparin-like compounds can potentially be used to inhibit breast cancer metastasis to bone.

These findings were published on the Molecular Cancer Research journal website on 20th April 2012.

The researchers at VTT used RNA interference-based screening in breast cancer cells and found that an enzyme that modifies heparan sulfate glycosaminoglycans, HS6ST2, is an important regulator of breast cancer cellbone interactions. Heparin, which is commonly used as an anticoagulant, also inhibited this regulatory mechanism.

Experiments in a mouse model of breast cancer bone metastasis indicated that heparin-like compounds decreased bone destruction and tumor growth in bone. One of these heparin-like compounds, developed by Biotie Therapies, has a significantly reduced anticoagulant activity as compared to heparin, which improves its applicability as a potential cancer therapeutic agent.

Breast cancer that has metastasized to bone is currently an incurable disease, causing significant morbidity and mortality.


'/>"/>
Contact: Merja Perl, Principal Scientist
merja.perala@vtt.fi
358-207-222-825
VTT Technical Research Centre of Finland
Source:Eurekalert

Page: 1

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Discovery of natural compounds that could slow blood vessel growth
3. New $11 million center to speed production of new compounds for drug discovery
4. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
5. Scripps research scientists identify compounds for stem-cell production from adult cells
6. Two new compounds show promise for eliminating breast cancer tumors
7. 2 new compounds show promise for eliminating breast cancer tumors
8. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
9. Compounds could be new class of cancer drugs
10. MSU discoveries upend traditional thinking about how plants make certain compounds
11. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2016)... According to the new market research report "Biometric System Market by Authentication ... (Hardware and Software), Function (Contact and Non-contact), Application, and Region - Global ... from USD 10.74 Billion in 2015 to reach USD 32.73 Billion by ... Continue Reading ... ...
(Date:11/19/2016)... Securus Technologies, a leading provider of civil and criminal ... monitoring, announced today that it has offered a challenge ... technology judge determine who has the largest and best ... platform, and the best customer service. "ICSolutions ... we do – which clearly is not the case ...
(Date:11/16/2016)... Sensory Inc ., a Silicon ... consumer electronics, and VeriTran , a technology ... today announced a global partnership that will provide ... users of mobile banking and mobile payments solutions.  ... which requires no specialized biometric scanners, yet provides ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... , Nov. 30, 2016 /PRNewswire/ - Portage Biotech ... Securities Exchange: PBT.U), is excited to announce the ... focused on developing preclinical ophthalmology assets through proof ... potent anti-inflammatory created by Portage Pharmaceuticals Limited and ... with ocular surface and anterior segment diseases. This ...
(Date:11/30/2016)... -- The Allen Institute for Cell Science has released ... collection of gene edited, fluorescently tagged human induced ... with unprecedented clarity. Distributed through the Coriell Institute ... crucial first step toward visualizing the dynamic organization ... cells healthy and what goes wrong in disease. ...
(Date:11/30/2016)... 2016  Tempus, a technology company focused on ... Abramson Cancer Center have partnered to better determine ... immunotherapy treatment based on next generation genomic and ... a research collaboration, Tempus will provide sequencing and ... data to Penn. Utilizing next-generation sequencing, machine learning ...
(Date:11/30/2016)... , 30. November 2016   Merck ... heute die Unterzeichnung einer Reihe von Vereinbarungen ... wird Evotec AG Screeningleistungen für Mercks Palette ... Der Zugriff auf diese Bibliotheken in Kombination ... einen schnelleren Weg zur Ermittlung und Erforschung ...
Breaking Biology Technology: