Navigation Links
Heparin-like compounds inhibit breast cancer metastasis to bone
Date:5/21/2012

Researchers from VTT Technical Research Centre of Finland have in collaboration with the University of Turku, Indiana University and two Finnish companies, Biotie Therapies Corp. and Pharmatest Services Ltd, discovered a novel mechanism regulating the development of breast cancer bone metastases and showed that heparin-like compounds can potentially be used to inhibit breast cancer metastasis to bone.

These findings were published on the Molecular Cancer Research journal website on 20th April 2012.

The researchers at VTT used RNA interference-based screening in breast cancer cells and found that an enzyme that modifies heparan sulfate glycosaminoglycans, HS6ST2, is an important regulator of breast cancer cellbone interactions. Heparin, which is commonly used as an anticoagulant, also inhibited this regulatory mechanism.

Experiments in a mouse model of breast cancer bone metastasis indicated that heparin-like compounds decreased bone destruction and tumor growth in bone. One of these heparin-like compounds, developed by Biotie Therapies, has a significantly reduced anticoagulant activity as compared to heparin, which improves its applicability as a potential cancer therapeutic agent.

Breast cancer that has metastasized to bone is currently an incurable disease, causing significant morbidity and mortality.


'/>"/>
Contact: Merja Perl, Principal Scientist
merja.perala@vtt.fi
358-207-222-825
VTT Technical Research Centre of Finland
Source:Eurekalert

Page: 1

Related biology news :

1. Duke team finds compounds that prevent nerve damage
2. Discovery of natural compounds that could slow blood vessel growth
3. New $11 million center to speed production of new compounds for drug discovery
4. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
5. Scripps research scientists identify compounds for stem-cell production from adult cells
6. Two new compounds show promise for eliminating breast cancer tumors
7. 2 new compounds show promise for eliminating breast cancer tumors
8. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
9. Compounds could be new class of cancer drugs
10. MSU discoveries upend traditional thinking about how plants make certain compounds
11. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... 16, 2016 The global wearable medical device market, in ... 2021 from USD 5.31 billion in 2016, at a CAGR of ... ... technological advancements in medical devices, launch of a growing number of ... connectivity among healthcare providers, and increasing focus on physical fitness. ...
(Date:12/15/2016)... 2016  There is much more to innovative access ... engine. Continental will demonstrate the intelligence of today,s solutions ... . Through the combination of the keyless entry and ... elements, the international technology company is opening up new ... "The integration of biometric elements brings our ...
(Date:12/7/2016)... 7, 2016 According to a new market research report ... (Facial Expression, Voice Recognition), Service, Application Area, End User, And Region - Global ... from USD 6.72 Billion in 2016 to USD 36.07 Billion by 2021, at ... Continue Reading ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 18, 2017 , ... ... of Health (NIH) to update its Data Sharing Policy. Specifically, the nation’s leading ... grant applications subject to the existing policy. AMIA recommended that NIH earmark funding ...
(Date:1/19/2017)... ... 19, 2017 , ... FireflySci Inc. is a go-getter type of company that ... accounted to two main factors. The first is the amazing customer service that ... FireflySci products all around the world. , 2016 was a tremendous sales year for ...
(Date:1/19/2017)... 2017 The global biotechnology services outsourcing ... by 2025, according to a new report by ... adaptive of the function of outsourcing certain clinical ... the services outsourced, clinical trial management and contract ... Johnson was the first pharmaceutical company to outsource ...
(Date:1/19/2017)... 18, 2017 Acupath Laboratories, Inc., a leading ... of an Executive Committee that will guide the company,s ... John Cucci , a 15-year veteran of the ... Business Development to Chief Sales Officer .  Prior ... in senior sales leadership roles at several leading lab ...
Breaking Biology Technology: