At a time when research funding is hard to come by, a University of Central Florida and University of Florida partnership has landed almost $5.5 million in National Institutes of Health highly competitive grants for hemophilia research.
The first grant worth $3.6 million over five years is aimed at determining whether a green technique pioneered at UCF will help make treatment of hemophilia A more effective. The second grant worth $2 million for four years is for similar research for hemophilia B. The grants were awarded to UCF and UF, which applied for funding jointly thanks to a long-time collaboration between scientists at both institutions. Duke University also is a partner for the research on hemophilia A.
Hemophilia is an incurable bleeding condition that affects about 400,000 adults and children worldwide. Hemophilia is characterized by defects in the gene that produces proteins required for blood to clot. Hemophilia A, the most common type of hemophilia, is characterized by prolonged or spontaneous bleeding, especially in the muscles, joints or internal organs.
Treating hemophilia is challenging and dangerous because many patients suffer fatal allergic reactions to the protein that doctors use to facilitate blood clotting. The scientists are working on a way to make patients resistant to any deadly allergic reactions caused by the protein.
Treatments with the protein are also expensive. They must be provided in a hospital setting under supervision, and they can cost up to $1 million over a patient's lifetime because of the required hospital stays and blood transfusions. Average annual treatment costs are $60,000 to $150,000, according to the National Hemophilia Foundation.
"I am confident we will achieve success sooner than you think," said UCF Professor Henry Daniell. "We are hopeful that this technique will potentially save thousands of lives."
The researchers are using genetically modified pl
|Contact: Zenaida Gonzalez Kotala|
University of Central Florida