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Helping horses come to term
Date:8/2/2013

d an early loss of pregnancy compared with those that either aborted much later (for whatever reason) or gave birth to live foals. The results suggest that high numbers of Tregs might somehow be required to suppress the mare's natural immune reaction against the conceptus. In other words, low levels of Treg cells in mares might cause pregnancy loss in the five weeks after fertilization.

The differences in the levels of Tregs between horses in the "successful pregnancy" and the "unsuccessful" groups were too small to be useful to predict whether an individual mare is likely to suffer early pregnancy failure. Nevertheless, the results may help breeders solve the problem. There is evidence from human medicine that oestradiol may enhance the function of Tregs during pregnancy and treatment with this hormone could possibly benefit mares prone to losing the conceptus. Another possible course would be to expose mares to the stallion's semen before implantation, which might increase the number of Tregs in the blood and the animal's tolerance to the conceptus, thereby helping avoid early pregnancy losses.

Aurich is optimistic: "A number of reasons have been proposed to account for early pregnancy failure in the horse but our work suggests that a low level of Tregs may actually be among the most important factors. It can only be a matter of time before we find out how to solve the problem."


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Contact: Susanna Kautschitsch
susanna.kautschitsch@vetmeduni.ac.at
43-125-077-1153
University of Veterinary Medicine -- Vienna
Source:Eurekalert

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