Navigation Links
Height, weight and BMI changes seen in children treated with peginterferon alpha for hepatitis C
Date:8/9/2012

Follow-up research from the Pediatric Study of Hepatitis C (PEDS-C) trial reveals that children treated with peginterferon alpha (pegIFNα) for hepatitis C (HCV) display significant changes in height, weight, body mass index (BMI), and body composition. Results appearing in the August issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, indicate that most growth-related side effects are reversible with cessation of therapy. However, in many children the height-for-age score had not returned to baseline two years after stopping treatment.

In the U.S. an estimated 240,000 children have the HCV antibody and up to 100,000 have chronic HCV (Jonas, 2002). "While HCV in children is typically mild, some cases do progress to cirrhosis and liver cancer," explains lead author Maureen Jonas, Director of the Center for Childhood Liver Disease and Medical Director of the Liver Transplant Program at Boston Children's Hospital in Massachusetts. "Treatment of HCV with peginterferon and ribavirin is approved for young children and offers the most benefit while liver disease is mild. However, there are concerns about the potential side effects of peginterferon therapy in children, which is the focus of our current study."

Children between the ages of 5 to 18 years with chronic HCV were recruited for the Pediatric Study of Hepatitis C (PEDS-C), a multi-center trial of the safety of pegIFNα with and without ribavirin that took place from December 2004 through May 2006. For the present study, children were followed for an additional two years to determine if height, weight, or BMI were affected by treatment. Subjects were placed into three groups based on duration of pegIFNα therapy at 24, 48 or 72 weeks.

The study group included 107 children with a mean age of 11 years of age; 55% were male, 82% were Caucasian, and all were of normal height, weight, BMI, and body composition at baseline. While
'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Tennessee professor releases weight management product
2. Hormone in fruit flies sheds light on diabetes cure, weight-loss drug for humans
3. Infants of overweight mothers grow more slowly
4. Weight-loss clinic drop-out rates are a huge barrier to treating obesity
5. Genetic link to rapid weight gain from antipsychotics discovered
6. Weight gain induced by high-fat diet increases active-period sleep and sleep fragmentation
7. Overweight? Theres a vaccine for that
8. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
9. Low vitamin D levels linked to weight gain in some older women
10. Eating disorder behaviors and weight concerns are common in women over 50
11. Omega-3 lowers inflammation in overweight older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 2015   Guidepoint , a leading global research ... Pain Management TRACKER, part of the Guidepoint TRACKER ... the medical device and therapeutics markets. The Post-Surgical Pain ... volumes, market share, and adoption rates across three major ... surgery. The Post-Surgical Pain Management TRACKER will ...
(Date:3/26/2015)... The Granite Club, Canada,s ... announced it has implemented a state-of-the-art access and security ... and staff, while restricting access to authorized users only. ... IMID Access system because it has the perfect combination ... in addition to unparalleled security," said James DiRenzo ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands by the following Segments: Face Biometrics, and ... Canada , Japan , ... Middle East & Africa , and ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... The ecological value of coastal mangrove forests in Mexico has ... first time, researchers have used a wide-ranging compilation of fisheries ... economic price tag on that value. Scientists at ... the new online edition of the Proceedings of the ...
... spread well beyond the continental shelf and drive carbon capture ... multi-year study. The finding does not change estimates of ... large role of tropical oceans and major rivers. The ... carbon from the respiration of ocean life. A 2007 study ...
... engineers have developed a new imaging system that allows ... mutation. The work, which could help scientists understand ... have been able to pinpoint the number and location ... In this case, the researchers worked with mouse pancreatic ...
Cached Biology News:Scripps study sets high economic value on threatened Mexican mangroves 2Scripps study sets high economic value on threatened Mexican mangroves 3Amazon powers tropical ocean's carbon sink 2MIT researchers offer glimpse of rare mutant cells 2
(Date:4/21/2015)... April 21, 2015  scPharmaceuticals, Inc., a ... products for subcutaneous delivery, announced today that ... its investigational proprietary drug product, Furosemide Injection ... with congestive heart failure. Concurrently ... a proprietary patch pump.  The patch pump ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 ... will sponsor and exhibit at the ACRP 2015 Global ... Lake City, Utah. The Association of Clinical Research Professionals ... clinical research conference solely focused on the conduct of ... training and development, and widely recognized industry certifications. , ...
(Date:4/21/2015)... 2015 Progyny, Inc., the new combined ... that it has secured additional capital from investors including ... One and Merck Serono Ventures. The funding will enable ... best fertility outcomes by aligning science, technology, clinics and ... for families seeking fertility solutions and we are committed ...
(Date:4/21/2015)... Springfield, Mo. (PRWEB) April 21, 2015 ... vessels, HOLLOWAY AMERICA is slated to discuss its custom ... also present its reimagined website, which launched just prior ... Wed. and Thurs. (April 21, 22 and 23) at ... than 12,000 representatives of the world’s largest and most ...
Breaking Biology Technology:scPharmaceuticals Announces Start of Pivotal Trial for Novel Furosemide Solution for Subcutaneous Delivery 2scPharmaceuticals Announces Start of Pivotal Trial for Novel Furosemide Solution for Subcutaneous Delivery 3PRC Clinical Sponsors The ACRP 2015 Global Conference And Meets Biotech Companies in the Salt Lake City Area. 2Announcing Progyny: Combining Best-in-Class Clinical Solutions with Consumer Expertise 2HOLLOWAY AMERICA to Reveal Newly Designed Responsive Website at INTERPHEX 2015 Today 2HOLLOWAY AMERICA to Reveal Newly Designed Responsive Website at INTERPHEX 2015 Today 3
... New Haven, Conn.A team led by Yale University scientists ... different cells in the blood using magnetizable liquids. The ... 7 in the online edition of the Proceedings ... improve the speed and sensitivity of tests used to ...
... quickly produce ultra-lightweight, bendable batteries and supercapacitors in ... a sheet of paper with ink made of ... conductive storage device, said Yi Cui, assistant professor ... needs a low-cost, high-performance energy storage device, such ...
... , QUINCY, Mass., ... International), a leading biotech developer and manufacturer of renewable biochemicals, ... to receive up to $50 million for its planned biobased ... integrated biorefinery projects that won funding or loan guarantees, Myriant ...
Cached Biology Technology:New technology could boost disease detection tests' speed and sensitivity 2Dip ordinary paper into ink infused with nanotubes and nanowires to create an instant battery 2Myriant Technologies LLC Selected for $50 Million Award for Succinic Acid Biorefinery Project 2
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
Chicken polyclonal to QPRT ( Abpromise for all tested applications). Antigen: Synthetic peptide, corresponding to Internal sequence amino acids 123-237 of Human QPRT Entrez Gene ID: 23475 ...
...
Antibody Diluent for IHC 125 ml...
Biology Products: