Navigation Links
Heidelberg researcher awarded Animal Welfare Prize of the German Research Foundation
Date:3/20/2014

Professor Thomas Korff of the Department of Physiology and Pathophysiology at Heidelberg University, Germany, will be awarded the German Research Foundation (DFG)'s Ursula M. Hndel Animal Welfare Prize on March 20, 2014, at a ceremony in Berlin. The physiologist investigates the formation and remodeling of blood vessels and has developed methods that minimize the distress experienced by animals and reduce the number of test animals. In certain areas, animal experiments can be replaced completely. Professor Korff plans to use the prize money in the amount of 100,000 euros to refine his methods and standardize them so that they can be introduced and applied in other research laboratories without a great deal of effort.

Blood vessels in the petri dish

The award winner and his group study the processes and mechanisms in blood vessels that underlie normal development as well as pathological remodeling processes associated with, e.g. atherosclerosis or varicose veins. In order to use human cells for his experiments to the greatest extent possible, Korff has developed special culture methods. To this end, he cultivates spherical cellular aggregates from cells that are isolated from the blood vessels of human umbilical cord after birth. These cell masses mimic two layers of the vessel wall.

This model system for human blood vessels is not only well suited for basic research, but is now also being used in industrial applications. Scientists from Beiersdorf AG in Hamburg, Germany, are using the model system to test the protective effect of cosmetic substances on microscopic skin vessels. "Since we categorically excludeanimal testing, we use these kinds of realistic methods with human cells, which are especially significant for us," said Dr. Gitta Neufang, Head of Medical Management at Beiersdorf AG.

Test mice affected as little as possible

"However, cell cultures reach their limits for applications beyond cosmetics, for instance, if we want to find out how and why vessels undergo pathological changes," Korff pointed out. In this case, it is not possible to avoid direct manipulations on animals, he clarified. "However, we have developed new surgical techniques that are much less stressful for the test animal than other proceduresused in vascular research." The new methods are easy to perform and mean less distress for the animals. "The animals behave normally and the success rate of the surgical procedures is higher. We need fewer animals for reliable results, which also reduces the costs," he added.

For experiments on the living organism, the team often uses the ear of the mouse, in which the blood vessels are already clearly visible with the naked eye. The mouse ear is also easily accessible for many imaging techniquesand is suitable as a model for investigating many research questions. Without a single incision, for instance, a vein can be tied off in order to raise blood pressure in the afferent vessels. In so doing, the formation of varicose veins can be simulated and their development observed over a period of several days. With this model, Korff investigates what signal pathways and molecules promote the pathological enlargement of the veins and whether certain substances can influence it. These kinds of studies are essential for identifying approaches for future therapeutic treatment.

In another project, the research group uses the mouse ear to investigate how tumors influence existing vessels or stimulate the formation of new vessels and, in so doing, can ensure their own blood supply. "Processes that are so complex can only be studied in live animals," Korff explained.


'/>"/>

Contact: Dr. Gerd König
gerd.koenig@physiologie.uni-heidelberg.de
49-622-154-4067
Heidelberg University Hospital
Source:Eurekalert  

Related biology news :

1. Miscarriage clues identified in new DNA test according to researchers at Montefiore and Einstein
2. Researchers uncover allergy-cancer connection
3. Vanderbilt diabetes researchers track cells ability to regenerate
4. Researchers devise new, stretchable antenna for wearable health monitoring
5. Researchers find high acceptability of 3-colored raspberry jelly
6. Motion and muscles dont always work in lockstep, researchers find in surprising new study
7. CNIO researcher awarded by the Prostate Cancer Foundation
8. New bilateral pilot opportunity will fund collaborations between US and UK bioscience researchers
9. Bucking conventional wisdom, researchers find black sea bass tougher than expected
10. Researchers reveal gap in carbon capture and sequestration education
11. Researchers show that bold baboons learn to solve tasks from other baboons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heidelberg researcher awarded Animal Welfare Prize of the German Research Foundation
(Date:6/13/2019)... BOSTON (PRWEB) , ... June 13, 2019 , ... ... Future of Spine & The Spine, Orthopedic and Pain Management-Driven ASC Conference in Chicago ... Hotels & Resorts 323 E. Wacker Dr. Chicago, IL in the 3rd floor Ticino ...
(Date:6/6/2019)... ... June 05, 2019 , ... ... in the global health and medical technology market, announced that it has selected ... / Robotics Solution” award in the 2019 MedTech Breakthrough Awards program. , ...
(Date:6/4/2019)... ... June 04, 2019 , ... Molecular Devices, a global leader ... the new President of Molecular Devices, replacing Greg Milosevich who has been appointed ... , Since joining Molecular Devices in a scientific engineering role, Ms. Murphy has ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... 2019 , ... Today, at the BIO World Congress on Industrial ... (NCGA) announced the winners of the Consider Corn Challenge II. Three winners were chosen, ... to produce biobased materials. , “Corn is a sustainable, abundant and affordable ...
(Date:6/26/2019)... (PRWEB) , ... June 26, 2019 , ... Alice Branton ... treatment on improving physicochemical properties of Magnesium Gluconate, which can prove to be beneficial ... 125% alteration of characteristic differentiation peak, change in crystallite size , Over ...
(Date:6/12/2019)... ... June 12, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, ... been signed. The agreement will grant exclusive rights for Zillion to represent LDA ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve ... its scientific journals to DeepDyve’s rental service for peer-reviewed journals. , IOPP’s ... of more than 20 million articles, sourced from more than 15,000 journals. , ...
Breaking Biology Technology: