Navigation Links
Heidelberg researcher awarded Animal Welfare Prize of the German Research Foundation
Date:3/20/2014

Professor Thomas Korff of the Department of Physiology and Pathophysiology at Heidelberg University, Germany, will be awarded the German Research Foundation (DFG)'s Ursula M. Hndel Animal Welfare Prize on March 20, 2014, at a ceremony in Berlin. The physiologist investigates the formation and remodeling of blood vessels and has developed methods that minimize the distress experienced by animals and reduce the number of test animals. In certain areas, animal experiments can be replaced completely. Professor Korff plans to use the prize money in the amount of 100,000 euros to refine his methods and standardize them so that they can be introduced and applied in other research laboratories without a great deal of effort.

Blood vessels in the petri dish

The award winner and his group study the processes and mechanisms in blood vessels that underlie normal development as well as pathological remodeling processes associated with, e.g. atherosclerosis or varicose veins. In order to use human cells for his experiments to the greatest extent possible, Korff has developed special culture methods. To this end, he cultivates spherical cellular aggregates from cells that are isolated from the blood vessels of human umbilical cord after birth. These cell masses mimic two layers of the vessel wall.

This model system for human blood vessels is not only well suited for basic research, but is now also being used in industrial applications. Scientists from Beiersdorf AG in Hamburg, Germany, are using the model system to test the protective effect of cosmetic substances on microscopic skin vessels. "Since we categorically excludeanimal testing, we use these kinds of realistic methods with human cells, which are especially significant for us," said Dr. Gitta Neufang, Head of Medical Management at Beiersdorf AG.

Test mice affected as little as possible

"However, cell cultures reach their limits for applications beyond cosmetics, for instance, if we want to find out how and why vessels undergo pathological changes," Korff pointed out. In this case, it is not possible to avoid direct manipulations on animals, he clarified. "However, we have developed new surgical techniques that are much less stressful for the test animal than other proceduresused in vascular research." The new methods are easy to perform and mean less distress for the animals. "The animals behave normally and the success rate of the surgical procedures is higher. We need fewer animals for reliable results, which also reduces the costs," he added.

For experiments on the living organism, the team often uses the ear of the mouse, in which the blood vessels are already clearly visible with the naked eye. The mouse ear is also easily accessible for many imaging techniquesand is suitable as a model for investigating many research questions. Without a single incision, for instance, a vein can be tied off in order to raise blood pressure in the afferent vessels. In so doing, the formation of varicose veins can be simulated and their development observed over a period of several days. With this model, Korff investigates what signal pathways and molecules promote the pathological enlargement of the veins and whether certain substances can influence it. These kinds of studies are essential for identifying approaches for future therapeutic treatment.

In another project, the research group uses the mouse ear to investigate how tumors influence existing vessels or stimulate the formation of new vessels and, in so doing, can ensure their own blood supply. "Processes that are so complex can only be studied in live animals," Korff explained.


'/>"/>

Contact: Dr. Gerd König
gerd.koenig@physiologie.uni-heidelberg.de
49-622-154-4067
Heidelberg University Hospital
Source:Eurekalert  

Related biology news :

1. Miscarriage clues identified in new DNA test according to researchers at Montefiore and Einstein
2. Researchers uncover allergy-cancer connection
3. Vanderbilt diabetes researchers track cells ability to regenerate
4. Researchers devise new, stretchable antenna for wearable health monitoring
5. Researchers find high acceptability of 3-colored raspberry jelly
6. Motion and muscles dont always work in lockstep, researchers find in surprising new study
7. CNIO researcher awarded by the Prostate Cancer Foundation
8. New bilateral pilot opportunity will fund collaborations between US and UK bioscience researchers
9. Bucking conventional wisdom, researchers find black sea bass tougher than expected
10. Researchers reveal gap in carbon capture and sequestration education
11. Researchers show that bold baboons learn to solve tasks from other baboons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heidelberg researcher awarded Animal Welfare Prize of the German Research Foundation
(Date:3/9/2017)... , Australia , March 9, 2017 ... data at the prestigious World Lung Imaging Workshop at ... Andreas Fouras , was invited to deliver the latest ... medicine. This globally recognised event brings together leaders at ... the latest developments in lung imaging. ...
(Date:3/6/2017)... , March 6, 2017 ... sales technology, today announced Predictive Sales Coach TM ... infusing actionable sales intelligence into Salesforce. This unique ... enable their sales organizations with deep knowledge of ... allow for intelligent engagement. Predictive Sales Coach extends ...
(Date:3/2/2017)... , March 2, 2017 Australian stem ... (ASX: CYP), has signed an agreement with the ... the Monash Biomedicine Discovery Institute and Department of Pharmacology ... conduct a further preclinical study to support the use ... of asthma.  Asthma is a chronic, ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... 23, 2017  GlobeImmune, Inc. today announced it has ... of 12,835,490 shares of its common stock to NantCell, ... connection with the sale of its common stock, NantCell ... issue to GlobeImmune 200,000 shares, an estimated $2.0 million ... "We are pleased to enter into this strategic agreement ...
(Date:3/23/2017)... ... 23, 2017 , ... Ellen Matloff, president and CEO of ... as a 2017 Women of Innovation® finalist. Matloff will be among several women ... The dinner recognizes women accomplished in science, technology, engineering and math (STEM), along ...
(Date:3/23/2017)... , March 23, 2017 NetworkNewsWire ... ... death, putting significant strain on health care systems, in terms ... diagnoses rises, so too does the development of innovative and ... side effects. Among the many types of cancer treatments, a ...
(Date:3/23/2017)... 2017  Agriculture technology company Cool Planet has closed ... conversion to commercialize its Cool Terra and Cool Fauna ... products that are simultaneously profitable as well as sustainable ... 18 months. This latest round of funding was led ... The company,s primary product, Cool Terra, can ...
Breaking Biology Technology: