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Hebrew University study opening new route for combating viruses
Date:6/25/2008

intriguing possibility that upon viral infection of a host cell, the virus may use microRNAs as weapons in its battle against the host, inhibiting the production of important host proteins.

Indeed, Elefant's algorithm predicted that an immune system protein, essential for the immune system's response against viruses, is inhibited by a viral microRNA. This prediction was confirmed in collaboration with the laboratory of Prof. Ofer Mandelboim of the Hebrew University Faculty of Medicine, who demonstrated experimentally that the microRNA aids the virus in evading the immune system. This study showed for the first time that a viral microRNA inhibits the activity of a gene of the human immune system, placing microRNAs as important players in the battle between viruses and humans.

The discovery holds promising therapeutic implications. It opens a new direction for anti-viral therapy aimed at inhibiting the viral microRNA, and it introduces a possible means to suppress the immune system in autoimmune diseases and transplantations by developing synthetic microRNAs that will mimic the action of natural microRNAs.


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Contact: Rebecca Zeffert
rebeccaz@savion.huji.ac.il
972-025-881-641
The Hebrew University of Jerusalem
Source:Eurekalert  

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