Navigation Links
Hebrew University study finds key mechanism in calcium regulation
Date:1/3/2013

Jerusalem, January 3, 2013 All living cells keep their cellular calcium concentration at a very low level. Since a small increase in calcium can affect many critical cellular functions (an elevated calcium concentration over an extended period can induce cell death), powerful cellular mechanisms ensure that calcium concentration quickly returns to its low level.

It is known that impairments of cellular calcium regulation underlie almost all neurodegenerative diseases. For example, age-related loss of calcium regulation was shown to promote cell vulnerability in Alzheimer's disease.

In a study recently published in the Journal of Neuroscience, Hebrew University of Jerusalem researchers, along with others from Israel and the US, presented their findings of a previously undescribed cellular mechanism which is essential for keeping cellular calcium concentration low. This mechanism operates together with other already characterized mechanisms.

Dr. Shirley Weiss and Prof. Baruch Minke of the Hebrew University's Institute of Medical Research Israel-Canada (IMRIC) and the Edmond and Lily Safra Center for Brain Sciences (ELSC) characterized this mechanism using photoreceptor cells of the fruit fly, which is a powerful model for studying basic biological processes.

They found that a protein-designated calphotin (a calcium buffer) operates by sequestering elevated calcium concentration. Genetic elimination of calphotin led to a light-induced rise in cellular calcium for an abnormally extended time, leading to retinal photoreceptor degeneration in the fruit flies.

The researchers stress that this kind of research, leading to a better understanding of the fundamental mechanisms underlying cellular calcium regulation, is critical for the development of new drugs and treatments for neurodegenerative diseases.


'/>"/>

Contact: Jerry Barach
Jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1

Related biology news :

1. Researchers at Hebrew University identify genetic systems disrupted in autistic brain
2. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
3. Carin Görings remains identified by researchers at Uppsala University
4. University of Alberta research working towards treatment for aortic aneurysms in the abdomen
5. University of Tennessee study predicts extreme climate in Eastern US
6. University of Illinois receives grant to study ozone resistance in corn
7. Mercyhurst University study probes impact of climate change on ectotherms
8. University of Illinois to improve crop yield through photosynthesis in a new global effort
9. University of Chicagos Graeme Bell receives international diabetes prize
10. University of Tennessee researchers find fungus has cancer-fighting power
11. University of Tennessee engineering professor looks to whirligig beetle for bio-inspired robots
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew University study finds key mechanism in calcium regulation
(Date:5/11/2015)... 2015  Synaptics Incorporated (NASDAQ: SYNA ), ... announced the appointment of Wajid Ali ... reporting to Rick Bergman , President and ... Officer, Kathleen Bayless , who announced her ... Ali brings extensive financial management expertise to Synaptics, ...
(Date:5/8/2015)... -- Synaptics Inc. (NASDAQ: SYNA ), the leading developer ... executive management team will present at the following investor events: ... Conference Date: May 18, 2015 Time: 10:40am ET ... Cowen and Company Technology, Media & Telecom ... New York Palace Hotel, New York, NY ...
(Date:4/27/2015)... 27, 2015  For more than four decades, AUVSI,s ... been the premier worldwide event for the unmanned land, ... must-attend event for any local, national, or trade news ... commercial markets and current applications of unmanned technologies. The ... projected $48 billion industry, and how it will soon ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... genetic techniques led by Adelaide researchers are making it ... protected rainforests. DNA fingerprinting for timber products has ... the University of Adelaide that traces individual ... they came from. Professor Andrew Lowe, Director of ...
... the Institute of Food Research and The Genome Analysis ... bacterium, to help understand how these organisms evolved their ... gut bacteria and the gastrointestinal tract is one of ... of bacteria in establishing and maintaining gut health is ...
... think nicotine receptors are only important to smokers trying ... published in the FASEB Journal ( http://www.fasebj.org ... role in social interaction and the ability to choose ... the nicotinic receptors in the prefrontal cortex are essential ...
Cached Biology News:Using DNA in fight against illegal logging 2Genome analysis will reveal how bacteria in our guts make themselves at home 2Your brain on nicotine: Nicotine receptors affect social behavior 2
(Date:5/21/2015)... uBiome, the leading startup focused ... PicnicHealth, a healthcare company that collects and consolidates ... Bowel Disease (IBD) will receive a complementary PicnicHealth ... kit. Both companies were funded by Y Combinator ... more information on this partnership and how to ...
(Date:5/21/2015)... May 21, 2015  CytRx Corporation (NASDAQ: ... specializing in oncology, today announced positive updated results ... aldoxorubicin for the treatment of unresectable glioblastoma multiforme ... open-label, multisite trial is designed to investigate the ... whose tumors have progressed following prior treatment with ...
(Date:5/21/2015)... 2015 Tunnell Consulting, Inc. ... as senior statistician and Principal, a position to which ... the management and analysis of complex and large data ... , “We’re delighted to have Julia join the Tunnell ... said Dr. Philippe Cini, Group Vice President and leader ...
(Date:5/20/2015)... , May 20, 2015  Select Medical Corporation ... Federal Trade Commission granted early termination of the ... Act of 1976, as amended, applicable to the ... Corporation, a joint venture that Select has created ... As previously announced, MJ Acquisition Corporation has ...
Breaking Biology Technology:uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... released its upcoming schedule of CLE accredited,teleconferences for tort litigators, ... , , Upcoming teleconferences include:, ... the State of the Art., February ... February 5 - Nanotechnology: Is it the Next Plastics or ...
... NEW YORK, Jan. 20 Immtech Pharmaceuticals, Inc. ... Company has appointed Virchow, Krause & Company, LLP ... immediately. The decision to change the Company,s independent ... Company,s board of directors. The appointment will ...
... REYKJAVIK, Iceland, Jan. 20 deCODE genetics (Nasdaq: ... agreement with NBI, an Icelandic financial institution, pursuant to which ... price of $11 million. Pursuant to the agreement, deCODE has ... back to the company at any time prior to December ...
Cached Biology Technology:Asbestos, Pharmaceutical Liability, Construction Defects, Nanotech: Covered by Targeted CLE Teleconferences 2Immtech Announces Appointment of Virchow Krause as Independent Registered Public Accounting Firm 2deCODE Sells Auction Rate Securities 2deCODE Sells Auction Rate Securities 3
Monoclonal antibodies conjugated with rhodamine...
... to Rhodopsin Rhodopsin is a glycoprotein ... birds, amphibians, and reptiles. The rhodopsin protein ... the retina. Immunogen: Membrane ... Specificity: This antibody specifically labels the ...
... 3′-(α-Amino- p- methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine, 2HCl ... PROTECT FROM MOISTURE. Protein synthesis inhibitor. ... of nascent polypeptide chains. Induces DNA ... HL-60 leukemia cells. Purity: ≥98% ...
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
Biology Products: