Navigation Links
Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
Date:5/6/2009

Jerusalem, May 5, 2009 Researchers at the Hebrew University of Jerusalem have discovered a method to potentially eliminate the tumor-risk factor in utilizing human embryonic stem cells. Their work paves the way for further progress in the promising field of stem cell therapy.

Human embryonic stem cells are theoretically capable of differentiation to all cells of the mature human body (and are hence defined as "pluripotent"). This ability, along with the ability to remain undifferentiated indefinitely in culture, make regenerative medicine using human embryonic stem cells a potentially unprecedented tool for the treatment of various diseases, including diabetes, Parkinson's disease and heart failure.

A major drawback to the use of stem cells, however, remains the demonstrated tendency of such cells to grow into a specific kind of tumor, called teratoma, when they are implanted in laboratory experiments into mice. It is assumed that this tumorigenic feature will be manifested upon transplantation to human patients as well. The development of tumors from embryonic stem cells is especially puzzling given that these cells start out as completely normal cells.

A team of researchers at the Stem Cell Unit in the Department of Genetics at the Silberman Institute of Life Sciences at the Hebrew University has been working on various approaches to deal with this problem.

In their latest project, the researchers analyzed the genetic basis of tumor formation from human embryonic stem cells and identified a key gene that is involved in this unique tumorigenicity. This gene, called survivin, is expressed in most cancers and in early stage embryos, but it is almost completely absent from mature normal tissues.

The survivin gene is especially highly expressed in undifferentiated human embryonic stem cells and in their derived tumors. By neutralizing the activity of survivin in the undifferentiated cells as well as in the t
'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Antioxidant to retard wrinkles discovered by Hebrew University researcher
2. Hebrew SeniorLife researchers search for aging, osteoporosis genes
3. Five young Hebrew University scientists win first competitive EU grants
4. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
5. Hebrew University study opening new route for combating viruses
6. Hebrew University develops novel approach for treating mitochondrial disorders
7. Scent on demand: Hebrew University scientists enhance the scent of flowers
8. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
9. Hebrew University professors work leads to FDA approval for product
10. A study by the MUHC and McGill University opens a new door to understanding cancer
11. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
(Date:12/11/2014)... 2014  That blood pressure plays a role in human ... the medical term for high blood pressure – was first ... inflatable cuff that,s used in measuring blood pressure was invented ... new about hypertension, its triggers and its effects. In fact, ... and the best ways to treat it. For ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... N.H. Small streams play a significant role in ... by removing nitrogen before it ends up in estuaries ... the journal Nature. University of New Hampshire professor William ... department of natural resources, are among the co-authors of ...
... one of the worlds most endangered speciesa North Island brown ... been incubating the egg for five weeks, following a month ... signs of pipping: the process in which the chick starts ... isolet for four days and is now in a specially ...
... minimizing the amount of human-generated pollutants, such as nitrogen, ... excess nitrogen degrades lakes and coastal oceans by stimulating ... phenomenon, also known as eutrophication, threatens fisheries around the ... that included Cary Institute ecologists Dr. Stuart E.G. Findlay ...
Cached Biology News:Streams remove significant amounts of nitrogen, preventing downstream 'dead zones' 2Rare North Island brown kiwi hatches at the Smithsonian's National Zoo 2Small streams mitigate human influence on coastal ecosystems 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... 6 Memory Pharmaceuticals,Corp. (Nasdaq: MEMY ) today ... Business Development, will provide a company update at,the Rodman ... 2008 at 11:10 a.m. EST at the New York ... access the live webcast of the presentation by,visiting the ...
... PHOENIX, Nov. 6 NutraCea (OTC Bulletin Board:,NTRZ), ... nutrient research and,technology announced today that it has ... Financial Officer. Todd Crow, in accordance with,his previously ... remain,available in a consulting and advisory capacity., ...
... today at 5:00 p.m. Eastern to discuss ... recent business highlights -, SAN DIEGO, Calif., Nov. 6 ... focused on,the treatment of obesity and other central nervous system-related,disorders, ... ended September 30, 2008., Three Months Ended September 30, ...
Cached Biology Technology:NutraCea Appoints New Chief Financial Officer 2Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 2Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 3Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 4Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 5Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 6Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 7Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 8Orexigen(R) Therapeutics Announces Third Quarter 2008 Financial Results 9
FluoSpheres® biotin-labeled microspheres, 1.0 µm, yellow-green fluorescent (505/515) *1% solids*...
chk 1 kinase...
muscle actin (HUC1-1)...
... The Human Neural Stem Cell ... media supplements, which can be used ... expansion of NSCs and the induction ... oligodendrocyte lineages. An antibody panel consisting ...
Biology Products: