Navigation Links
Hebrew University, American researchers show 'trigger' to stem cell differentiation
Date:12/10/2009

Jerusalem A gene which is essential for stem cells' capabilities to become any cell type has been identified by researchers at the Hebrew University of Jerusalem and the University of California, San Francisco.

The discovery represents a further step in the ever-expanding field of understanding the ways in which stem cells develop into specific cells, a necessary prelude towards the use of stem cell therapy as a means to reverse the consequences of disease and disability.

The identification of the gene, known as Chd1, was made by Dr. Eran Meshorer of the Alexander Silberman Institute of Life Sciences at the Hebrew University and Dr. Miguel Ramalho-Santos (UCSF), together with their graduate students Adi Alajem (the Hebrew University) and Alexandre Gaspar-Maia (UCSF).

Embryonic stem (ES) cells, which are primary cells derived from the early developing embryo, are capable of giving rise, according to their environment and conditions, to any cell type -- a trait known as pluripotency.

It was assumed that the ES cells have a relatively high degree of open chromatin, which is thought to enable their pluripotency, a theory which awaited proof. Chromatin, which is found in all cells, is composed of DNA and its surrounding proteins and can be found in one of two conformations: closed chromatin (heterochromatin) when the genetic material is packed in a way that prevents the expression of the genes -- and open chromatin (euchromatin) when chromatin is accessible to the gene expression machinery. Different cells display varying degrees of open and closed chromatin as a function of the genes required for their function.

In their current study, which was published recently in Nature magazine, the researchers from the Hebrew University and UCSF showed, using mouse ES cells, that Chd1 regulates open chromatin in ES cells. The open chromatin conformation, maintained by Chd1, enabled the expression of a wide variety of genes, leading to proper differentiation into all types of specific cells. Depletion of Chd1 in embryonic stem cells led to formation of heterochromatin (closed chromatin) and prevented the ability of the cells to generate all types of tissues.

The study, therefore, showed a proven link between open chromatin in ES cells and their pluripotency an important finding on the road to the implementation of stem cell applications in future medical treatment.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related biology news :

1. Antioxidant to retard wrinkles discovered by Hebrew University researcher
2. Hebrew SeniorLife researchers search for aging, osteoporosis genes
3. Five young Hebrew University scientists win first competitive EU grants
4. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
5. Hebrew University study opening new route for combating viruses
6. Hebrew University develops novel approach for treating mitochondrial disorders
7. Scent on demand: Hebrew University scientists enhance the scent of flowers
8. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
9. Hebrew University professors work leads to FDA approval for product
10. Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
11. Promising new treatment for Alzheimers suggested based on Hebrew University research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew University, American researchers show 'trigger' to stem cell differentiation
(Date:1/28/2016)... SYNA ), a leading developer of human interface solutions, today ... --> --> Net revenue ... to the comparable quarter last year to $470.5 million. Net income ... $0.93 per diluted share. --> ... 2016 grew 9 percent over the prior year period to $60.3 ...
(Date:1/25/2016)... Pa. , Jan. 25, 2016   Unisys Corporation ... system at John F. Kennedy (JFK) International Airport, New ... Protection (CBP) identify imposters attempting to enter the ... not belong to them. pilot testing of the ... initially at three terminals at JFK during January 2016. --> ...
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , ... February 10, 2016 , ... ... three states, announced today the promotion of two long-standing principal investigators (PI) to ... Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, a Benchmark Research ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... on Microsoft Azure. On Azure, Arvados provides capabilities for managing and processing genomic ... for Microsoft Azure from major institutions collecting and analyzing genomic data,” said Adam ...
(Date:2/9/2016)... 2016  Regenicin, Inc. (OTC Bulletin Board: ... development and commercialization of regenerative cell therapies to ... recently reported the Company,s operating results for 2015 ... Lonza America , Inc. (the "Lonza ... in the process of consummating an agreement to ...
(Date:2/9/2016)... ... February 09, 2016 , ... The American Academy of Thermology ... offering its 2016 AAT Member Certification Qualification Course for Technicians via a two part ... which will include a detailed review of hardware, software, and camera setup/operations, aligns with ...
Breaking Biology Technology: