Navigation Links
Hebrew University, American researchers show 'trigger' to stem cell differentiation

Jerusalem A gene which is essential for stem cells' capabilities to become any cell type has been identified by researchers at the Hebrew University of Jerusalem and the University of California, San Francisco.

The discovery represents a further step in the ever-expanding field of understanding the ways in which stem cells develop into specific cells, a necessary prelude towards the use of stem cell therapy as a means to reverse the consequences of disease and disability.

The identification of the gene, known as Chd1, was made by Dr. Eran Meshorer of the Alexander Silberman Institute of Life Sciences at the Hebrew University and Dr. Miguel Ramalho-Santos (UCSF), together with their graduate students Adi Alajem (the Hebrew University) and Alexandre Gaspar-Maia (UCSF).

Embryonic stem (ES) cells, which are primary cells derived from the early developing embryo, are capable of giving rise, according to their environment and conditions, to any cell type -- a trait known as pluripotency.

It was assumed that the ES cells have a relatively high degree of open chromatin, which is thought to enable their pluripotency, a theory which awaited proof. Chromatin, which is found in all cells, is composed of DNA and its surrounding proteins and can be found in one of two conformations: closed chromatin (heterochromatin) when the genetic material is packed in a way that prevents the expression of the genes -- and open chromatin (euchromatin) when chromatin is accessible to the gene expression machinery. Different cells display varying degrees of open and closed chromatin as a function of the genes required for their function.

In their current study, which was published recently in Nature magazine, the researchers from the Hebrew University and UCSF showed, using mouse ES cells, that Chd1 regulates open chromatin in ES cells. The open chromatin conformation, maintained by Chd1, enabled the expression of a wide variety of genes, leading to proper differentiation into all types of specific cells. Depletion of Chd1 in embryonic stem cells led to formation of heterochromatin (closed chromatin) and prevented the ability of the cells to generate all types of tissues.

The study, therefore, showed a proven link between open chromatin in ES cells and their pluripotency an important finding on the road to the implementation of stem cell applications in future medical treatment.


Contact: Jerry Barach
The Hebrew University of Jerusalem

Related biology news :

1. Antioxidant to retard wrinkles discovered by Hebrew University researcher
2. Hebrew SeniorLife researchers search for aging, osteoporosis genes
3. Five young Hebrew University scientists win first competitive EU grants
4. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
5. Hebrew University study opening new route for combating viruses
6. Hebrew University develops novel approach for treating mitochondrial disorders
7. Scent on demand: Hebrew University scientists enhance the scent of flowers
8. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
9. Hebrew University professors work leads to FDA approval for product
10. Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
11. Promising new treatment for Alzheimers suggested based on Hebrew University research
Post Your Comments:
Related Image:
Hebrew University, American researchers show 'trigger' to stem cell differentiation
(Date:10/29/2015)... 2015  The J. Craig Venter Institute (JCVI) policy ... and Biosecurity: Lessons Learned and Options for the Future," ... Human Services guidance for synthetic biology providers has worked ... --> --> Synthetic biology promises ... to pose unique biosecurity threats. It now is easier ...
(Date:10/29/2015)... NXTD ) ("NXT-ID" or ... the growing mobile commerce market and creator of ... leading marketplace to discover and buy innovative technology ... on StackSocial for this holiday season.   ... a biometric authentication company focused on the growing ...
(Date:10/27/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... has adopted the Synaptics ® ClearPad ® ... its newest flagship smartphones, the Nexus 5X by LG ... --> --> Synaptics works closely ... collaboration in the joint development of next generation technologies. ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
(Date:11/24/2015)... -- SHPG ) announced today that Jeff Poulton ... th Annual Healthcare Conference in New York City ... EST (1:30 p.m. GMT). --> SHPG ) announced today ... the Piper Jaffray 27 th Annual Healthcare Conference in ... 2015, at 8:30 a.m. EST (1:30 p.m. GMT). --> ...
Breaking Biology Technology: