Navigation Links
Hebrew University, American researchers show 'trigger' to stem cell differentiation
Date:12/10/2009

Jerusalem A gene which is essential for stem cells' capabilities to become any cell type has been identified by researchers at the Hebrew University of Jerusalem and the University of California, San Francisco.

The discovery represents a further step in the ever-expanding field of understanding the ways in which stem cells develop into specific cells, a necessary prelude towards the use of stem cell therapy as a means to reverse the consequences of disease and disability.

The identification of the gene, known as Chd1, was made by Dr. Eran Meshorer of the Alexander Silberman Institute of Life Sciences at the Hebrew University and Dr. Miguel Ramalho-Santos (UCSF), together with their graduate students Adi Alajem (the Hebrew University) and Alexandre Gaspar-Maia (UCSF).

Embryonic stem (ES) cells, which are primary cells derived from the early developing embryo, are capable of giving rise, according to their environment and conditions, to any cell type -- a trait known as pluripotency.

It was assumed that the ES cells have a relatively high degree of open chromatin, which is thought to enable their pluripotency, a theory which awaited proof. Chromatin, which is found in all cells, is composed of DNA and its surrounding proteins and can be found in one of two conformations: closed chromatin (heterochromatin) when the genetic material is packed in a way that prevents the expression of the genes -- and open chromatin (euchromatin) when chromatin is accessible to the gene expression machinery. Different cells display varying degrees of open and closed chromatin as a function of the genes required for their function.

In their current study, which was published recently in Nature magazine, the researchers from the Hebrew University and UCSF showed, using mouse ES cells, that Chd1 regulates open chromatin in ES cells. The open chromatin conformation, maintained by Chd1, enabled the expression of a wide varie
'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Antioxidant to retard wrinkles discovered by Hebrew University researcher
2. Hebrew SeniorLife researchers search for aging, osteoporosis genes
3. Five young Hebrew University scientists win first competitive EU grants
4. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
5. Hebrew University study opening new route for combating viruses
6. Hebrew University develops novel approach for treating mitochondrial disorders
7. Scent on demand: Hebrew University scientists enhance the scent of flowers
8. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
9. Hebrew University professors work leads to FDA approval for product
10. Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
11. Promising new treatment for Alzheimers suggested based on Hebrew University research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew University, American researchers show 'trigger' to stem cell differentiation
(Date:1/22/2015)... , Europe,s ... European Patent Office to present a video retrospective of the most ... featured: Christofer Toumazou and Sophie Wilson   ... of the Award   Starting on 22 January 2015 ...
(Date:12/24/2014)... Dec. 23, 2014  Since its launch in December 2014, the ... the pain of trying to remember their usernames and passwords ... to their smartphones. To assist people who have struggled to ... that created 1U and focuses on redefining identity, announced today ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and Markets ... of the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... 2012, Apple introduced the fingerprint reading feature with the ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 31U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... international team of scientists has identified a nesting population ... the world,s largest. The research, published in the May ... and aerial surveys that estimated a population of between ... The study highlights the importance of conservation work to ...
... A new sponge-like material that is black, brittle and ... pull off some pretty impressive feats. Designed by Northwestern ... easily separate hydrogen from other gases and, perhaps most ... the one currently used to pull sulfur out of ...
... with collaborators from research institutions across Europe and the ... genes that are involved in determining when girls begin ... Genetics this weekend. The findings of the ... weight too, because early-age menstruation is also associated with ...
Cached Biology News:Scientists identify world's largest leatherback turtle population 2One sponge-like material, three different applications 2One sponge-like material, three different applications 3Genes that influence start of menstruation identified for first time 2
(Date:1/22/2015)... January 22, 2015 The laboratory information ... has witnessed a number of technological advancements due to ... requirements, growing need to integrate healthcare systems, and increasing ... challenges in system integration. Key players in the market ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... zFlo Motion , a US leader in biomechanics ... from a new partner. STT-Systems has developed an ... years, with offerings in the optical-motion capture, 3D scanning, and ... measurement unit), iSen, is opening eyes around the world. With ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project ... the legal requirements around using controlled substances in pharmaceutical ... As their international operations expand and become increasingly complex, ... as a result of the first phase of the ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2
... to Pursue Cures for Patients, ... Human Cloning, WASHINGTON, Aug. 22 Today, a new ... funds,support cures for patients, without involving human cloning. Tony ... on the new initiative, Cures Without Cloning. "I applaud ...
... ... 2007, COPENHAGEN, August 22 ... 30, 2007.,During this period, Genmab reported the following results: Genmab,s revenues were ... the same period of 2006, Genmab recognized DKK,74.3 million (approx. USD 13.5 million) ...
... NuVasive, Inc. (Nasdaq:,NUVA), a medical device company focused ... the spine, announced today,that Kevin O,Boyle, Executive Vice ... at the Thomas Weisel Partners Healthcare Conference,at the ... 6, 2007, at,9:45 a.m. ET. A live ...
Cached Biology Technology:Genmab Announces 2007 First Half Year Results 2Genmab Announces 2007 First Half Year Results 3Genmab Announces 2007 First Half Year Results 4NuVasive to Present at Thomas Weisel Partners Healthcare Conference 2NuVasive to Present at Thomas Weisel Partners Healthcare Conference 3
... NightOWL is a dedicated imaging system ... size. Equipped with a very sensitive camera ... or plants in tumor research, infectious disease ... Western blots. NightOWL is the only imager ...
Mouse polyclonal antibody raised against a partial recombinant TSEN2. NCBI Entrez Gene ID = 80746...
Mouse monoclonal antibody raised against a partial recombinant RAB11B. NCBI Entrez Gene ID = RAB11B...
...
Biology Products: