Navigation Links
Hebrew U. scientists show for first time how early human embryo acquires its shape
Date:7/19/2011

Jerusalem, July 19, 2011 -- How is it that a disc-like cluster of cells transforms within the first month of pregnancy into an elongated embryo? This mechanism is a mystery that man has tried to unravel for millennia.

The first significant step towards understanding the issue was made nearly a century ago in experiments conducted by the German embryologists Hans Spemann and Hilde Mangold. The two used early newt embryos and identified a group of cells within them which, upon transplantation, formed a two-headed tadpole.

In trying to understand why this happened, they concluded that what occurred is that the transplanted cells organized the vicinity into which they were placed to form a typical embryonic shape. They therefore dubbed such cells "organizer" cells. The newt embryo possessed both its own organizers and the transplanted ones, both of which organized nearby cells to form a head structure.

Recently, Israeli scientists from the Hebrew University of Jerusalem have managed to generate human organizer cells, using human embryonic stem cells. Based on the similarity that dominates the initial developmental processes of all vertebrates, the group raised the human cells in conditions which recapitulate those of early amphibian embryogenesis. Within two days, the human cells started expressing genes characteristic of the organizer cells.

To verify that these cells derived from human embryonic stem cells posses a true organizing ability, the researchers repeated Spemann and Mangold's experiments. Only this time, the human cells, rather than those of amphibians, were transplanted into frog embryos.

The midline of an amphibian embryo is marked by a neural tube a tissue destined to form the embryo's central nervous system. To the group's astonishment, some of the frog embryos that were transplanted with the human cells possessed not one but two neural tubes. The second tube was composed from frog cells, proving that the injected human cells organized the cells in their vicinity to acquire a tubular shape.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related biology news :

1. Research teams at Hebrew University, University of Kentucky win Israel-US science award
2. Two Hebrew University professors win prestigious Canadian medical science award
3. Researchers from Hebrew U., US discover how mercury gets into fish we eat
4. Climate change threatens many tree species, say Hebrew U. researchers
5. Hebrew University research carries cautionary warning for future stem cell applications
6. Unlike us, honeybees naturally make quick switch in their biological clocks, says Hebrew University researcher
7. Hebrew University research holds promise for development of new osteoporosis drug
8. How algae enslavement threatens freshwater bodies described by Hebrew University researcher
9. Hebrew University researchers identify gene related to chronic pain
10. Research on stem cells wins first prize for Hebrew University researcher
11. JDRF, Pfizer, Hadassah Medical and the Hebrew University announce collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew U. scientists show for first time how early human embryo acquires its shape 
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber Ventures ... it has led a $3.5 million investment in  Polarity ... Strategic Cyber Ventures is DC based and is led ... Hank Thomas . Ron Gula , also a ... also participated in this series A round of funding. ...
(Date:2/22/2017)... 2017 With the biometrics market to ... four technologies that innovative and agile startups must ... in the changing competitive landscape: multifactor authentication (MFA), ... "Companies can no longer afford to ... Dimitrios Pavlakis , Industry Analyst at ABI ...
(Date:2/16/2017)... 2017  Genos, a community for personal genetic ... received Laboratory Accreditation from the College of American ... laboratories that meet stringent requirements around quality, accuracy ... "Genos is committed to maintaining the ... honored to be receiving CAP accreditation," said ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... , ... March 21, 2017 , ... ... , more than tripling its goal and raising over $30,000 in the first ... that grows nutritious veggies & herbs fast, easy, and affordably, anywhere. , “Simply ...
(Date:3/22/2017)... ... March 21, 2017 , ... ... peristaltic pump with patented ReNu single-use (SU) cartridge technology. Engineered by the ... feed pumps in SU tangential flow filtration (TFF), virus filtration (VF) and ...
(Date:3/22/2017)... , ... March 22, 2017 , ... The Society for ... agencies as outlined in the Administration’s recently published fiscal year 2018 budget request. ... Institutes of Health (NIH) by $5.8 billion or roughly 20% of its total budget. ...
(Date:3/22/2017)... and PETACH TIKVAH, Israel ... (NASDAQ: BCLI), a leading developer of adult stem cell ... Lebovits , Chief Executive Officer, will provide an update ... Associates 2 nd Annual Neuroscience Biopartnering and Investment ... the New York Academy of Sciences. ...
Breaking Biology Technology: