Navigation Links
Hebrew U. scientists show for first time how early human embryo acquires its shape
Date:7/19/2011

Jerusalem, July 19, 2011 -- How is it that a disc-like cluster of cells transforms within the first month of pregnancy into an elongated embryo? This mechanism is a mystery that man has tried to unravel for millennia.

The first significant step towards understanding the issue was made nearly a century ago in experiments conducted by the German embryologists Hans Spemann and Hilde Mangold. The two used early newt embryos and identified a group of cells within them which, upon transplantation, formed a two-headed tadpole.

In trying to understand why this happened, they concluded that what occurred is that the transplanted cells organized the vicinity into which they were placed to form a typical embryonic shape. They therefore dubbed such cells "organizer" cells. The newt embryo possessed both its own organizers and the transplanted ones, both of which organized nearby cells to form a head structure.

Recently, Israeli scientists from the Hebrew University of Jerusalem have managed to generate human organizer cells, using human embryonic stem cells. Based on the similarity that dominates the initial developmental processes of all vertebrates, the group raised the human cells in conditions which recapitulate those of early amphibian embryogenesis. Within two days, the human cells started expressing genes characteristic of the organizer cells.

To verify that these cells derived from human embryonic stem cells posses a true organizing ability, the researchers repeated Spemann and Mangold's experiments. Only this time, the human cells, rather than those of amphibians, were transplanted into frog embryos.

The midline of an amphibian embryo is marked by a neural tube a tissue destined to form the embryo's central nervous system. To the group's astonishment, some of the frog embryos that were transplanted with the human cells possessed not one but two neural tubes. The second tube was composed from frog cells, proving
'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research teams at Hebrew University, University of Kentucky win Israel-US science award
2. Two Hebrew University professors win prestigious Canadian medical science award
3. Researchers from Hebrew U., US discover how mercury gets into fish we eat
4. Climate change threatens many tree species, say Hebrew U. researchers
5. Hebrew University research carries cautionary warning for future stem cell applications
6. Unlike us, honeybees naturally make quick switch in their biological clocks, says Hebrew University researcher
7. Hebrew University research holds promise for development of new osteoporosis drug
8. How algae enslavement threatens freshwater bodies described by Hebrew University researcher
9. Hebrew University researchers identify gene related to chronic pain
10. Research on stem cells wins first prize for Hebrew University researcher
11. JDRF, Pfizer, Hadassah Medical and the Hebrew University announce collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew U. scientists show for first time how early human embryo acquires its shape 
(Date:4/18/2014)... feeding a world population predicted to reach 9 ... to conservation that considers human-altered landscapes such as ... the natural habitat that supports it might be ... at least three-quarters of the land surface is ... vulnerable to human-caused impacts such as climate change. ...
(Date:4/18/2014)... Ancient DNA adds a twist to the story of how ... published April 21 in the journal Proceedings of the ... bones of chickens that lived 200-2300 years ago in Europe, ... chickens may have looked far different from the chickens we ... traits we associate with modern domestic chickens -- such as ...
(Date:4/18/2014)... and comet impacts can cause widespread ecological havoc, killing ... scales. But new research from Brown University shows that ... at the time of an impact. , A research ... fragments of leaves and preserved organic compounds lodged inside ... The material could provide a snapshot of environmental conditions ...
Breaking Biology News(10 mins):Stanford researchers rethink 'natural' habitat for wildlife 2Stanford researchers rethink 'natural' habitat for wildlife 3Stanford researchers rethink 'natural' habitat for wildlife 4Ancient DNA offers clues to how barnyard chickens came to be 2Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
... horned beetles' wild protrusions has been a matter of ... mate selection, more likely. Even Charles Darwin once weighed ... some frustration -- the horns were merely ornamental. ... the Nov. 2006 issue of Evolution, Indiana University Bloomington ...
... age 40 and older have a significantly increased risk ... fathers are younger than 30 years, according to an ... Psychiatry, one of the JAMA/Archives journals. , Autism is ... of behavior, according to background information in the article. ...
... the University of Warwick is developing an entirely new ... shown to protect animals against various strains of flu, ... influenza A infections, including H5N1 and any new pandemic ... instant protection, and completely prevents flu symptoms developing by ...
Cached Biology News:Vanishing beetle horns have surprise function 2Vanishing beetle horns have surprise function 3Older fathers more likely to have autistic children 2'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines 2'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines 3
(Date:1/14/2014)... 2014 In recent years, growing suspicion ... in product development and promotion has led to unprecedented ... fueled by concerns about the insidious impact of commercialization ... spectacular fines to the world’s biggest pharmas for illegal ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... 14, 2014 During the 1600’s through the ... “The Doctor’s Plague.” In this time period, doctors did not ... at times, to the death of vulnerable patients. In the ... that they may be unwittingly transmitting herpes viruses to their ...
(Date:1/14/2014)... Springfield, MO (PRWEB) January 14, 2014 ... a comprehensive database of material test reports (MTRs) for ... and fabricates. Documenting test results is particularly important for ... other regulations. The MTR Library features search functionality that ...
Breaking Biology Technology:The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 2Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 3
... CryoLife, Inc. (NYSE: CRY ), a,biomaterials, medical ... scheduled to participate in the FBR Capital Markets Annual,Spring ... Hyatt Hotel,in New York City., Steven G. Anderson, ... at 12:50 p.m. Eastern Time., CryoLife,s live presentation ...
... Neb., May 27 Pacific,Biosciences announced today ... from LI-COR Biosciences of Lincoln Nebraska.,Sequencing by ... based upon synthesis of a complementary DNA ... Biosciences, existing intellectual,property related to the SMRT(TM), ...
... 27 Cord Blood America, Inc.,(OTC Bulletin Board: ... ( http://www.cordblood-america.com ) focused on bringing the ... and internationally,today reported that CorCell Companies Inc., Philadelphia, ... first operationally profitable quarter,ever for the three months ...
Cached Biology Technology:CryoLife to Present at FBR Capital Markets Annual Spring Investor Conference 2Pacific Biosciences Acquires Single Molecule Sequencing Technology from LI-COR Biosciences 2Pacific Biosciences Acquires Single Molecule Sequencing Technology from LI-COR Biosciences 3Cord Blood America Reports CorCell, Its Major Acquisition in 2006, Turns Profitable 2
...
... Multidizer is designed with a variety of ... - all in one unit. Shake, rock, ... operating compartments allow for hybridization and blotting ... , The upper chamber uses a ...
... sleek design loaded with class-leading features, the 1400 Series ... work is safe and consistent every time you use ... 1400 Series reduces power consumption by as much as ... over the life of the cabinet. Multiply this ...
... Concentrator, the SPD series takes the 'Classic' ... twist., The SPD121P SpeedVac comes equipped with ... runs; preventing samples from freezing; and allowing ... end-users preset level., Standard features on the ...
Biology Products: