Navigation Links
Hebrew SeniorLife researchers search for aging, osteoporosis genes
Date:9/20/2007

(Boston, Mass.) Researchers at Hebrew SeniorLifes Institute for Aging Research (IFAR) have examined close to 100,000 genetic markers for low bone mass and aging to help determine which genes are responsible for the development of osteoporosis and longevity.

One of the HSL studies surveyed the entire human genome (all the genetic material in a living organism), called a genome-wide association study (GWAS), to look for common genetic variations in hereditary osteoporosis traits, such as bone mineral density.

Weve examined nearly 100,000 genetic markers, says Douglas Kiel, M.D., M.P.H., director of medical research at IFAR and co-author of two of the papers, Were using this data and bone measurements over the years to see if bone mass is associated with certain genetic markers. Were looking for the genes for osteoporosis.

The other study, conducted by HSL investigators in collaboration with Boston University colleagues, took a GWAS approach to detecting genes related to longevity and aging traits. Two candidates are FOXO1a, which is associated with age at death, and PON1, which is associated with age at death and illness-free survival. These findings, if replicated in others studies, may help scientists understand better the mechanisms responsible for aging and, in turn, aid in health promotion and disease prevention.

The studies, published as part of a 17-paper supplement to the online, open-access journal BMC Medical Genetics, examined the genetic differences that potentially affect the risk for certain diseases, using data collected from the landmark Framingham Heart Study (FHS).

The studies evaluated DNA at 100,000 sites along the human genome where people are known to commonly differ. Researchers then looked for associations between the genotypes (the genetic makeup encoded in an individuals DNA) and hundreds of clinical phenotype measures (observable, physical characteristics) from nearly 60 years of FHS data, including biomarkers for cardiovascular disease, cancer, osteoporosis, longevity and aging, and renal and endocrine function, among others.

In addition to BMC Medical Genetics, the results of the studies are also available through an online database of genotypes and phenotypes (http://view/ncbi.nlm.nih.gov/dbgap), which provides a number of electronic enhancements for viewing and examining the data, such as enabling users to drill down for precise details on all associations and allowing the data to be explored in the context of other National Center for Biotechnology Information genomic resources.

It is important to remember, says David Karasik, Ph.D., an associate scientist at IFAR and co-author of the HSL papers, that we need to replicate our findings in other studies. We havent found the genes for osteoporosis and aging, but weve generated a hypothesis for future work.


'/>"/>

Contact: Scott Edwards
edwards@hrca.harvard.edu
617-363-8385
Hebrew SeniorLife Institute for Aging Research
Source:Eurekalert

Related biology news :

1. New protein discovered by Hebrew University researchers
2. Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher
3. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
4. A first -- Hebrew University scientist observes brain cell development in real time
5. Researchers discover way to make cells in the eye sensitive to light
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Researchers Uncover Key Step In Manufacture of Memory Protein
8. NYU researchers simulate molecular biological clock
9. Researchers reveal the infectious impact of salmon farms on wild salmon
10. Researchers identify target for cancer drugs
11. Vital step in cellular migration described by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2017)... , Feb. 6, 2017 According to ... are driving border authorities to continue to embrace ... there are 2143 Automated Border Control (ABC) eGates ... deployed at more than 163 ports of entry ... to 2016 achieving a combined CAGR of 37%. ...
(Date:2/2/2017)... , Feb. 1, 2017  Central to ... and meaningful advances worldwide, The Japan Prize Foundation ... Prize, who have pushed the envelope in their ... and Communication. Three scientists are being recognized with ... achievements that not only contribute to the advancement ...
(Date:1/26/2017)... 26, 2017  Acuity Market Intelligence today released ... Digital Identity".  Acuity characterizes 2017 as a "breakout" ... adoption reflects a new understanding of the potential ... and digital identity are often perceived as threats ... , Principal of Acuity Market intelligence. "However, taken ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... ... February 17, 2017 , ... The BMT Tandem ... Center for International Blood & Marrow Transplant Research (CIBMTR) will take place Feb. ... , The combined scientific sessions offer investigators, clinicians, laboratory technicians, clinical research professionals, ...
(Date:2/17/2017)... According to a new ... Service), Type (Safety, Efficacy, Validation), Disease Indication (Cancer, ... Development, Disease-Risk) - Global Forecast to 2021" published ... USD 53.34 Billion by 2021 from USD 27.95 ... 13.8% during the forecast period (2016-2021). ...
(Date:2/17/2017)... ... February 17, 2017 , ... Academy of Model ... world’s leading maker of unmanned aircraft systems (UAS), are launching a joint program ... drones effectively, and support educational outreach efforts. , AMA and DJI will collaborate ...
(Date:2/16/2017)... ... February 16, 2017 , ... Avomeen & MichBio will be hosting a BioMixer ... at Avomeen Analytical Services (4840 Venture Dr., Ann Arbor, Michigan 48108). BioMixers are ... opportunity to interact with peers, make new connections and talk bio biz. , Cost:, ...
Breaking Biology Technology: