Navigation Links
Hebrew SeniorLife researchers search for aging, osteoporosis genes
Date:9/20/2007

(Boston, Mass.) Researchers at Hebrew SeniorLifes Institute for Aging Research (IFAR) have examined close to 100,000 genetic markers for low bone mass and aging to help determine which genes are responsible for the development of osteoporosis and longevity.

One of the HSL studies surveyed the entire human genome (all the genetic material in a living organism), called a genome-wide association study (GWAS), to look for common genetic variations in hereditary osteoporosis traits, such as bone mineral density.

Weve examined nearly 100,000 genetic markers, says Douglas Kiel, M.D., M.P.H., director of medical research at IFAR and co-author of two of the papers, Were using this data and bone measurements over the years to see if bone mass is associated with certain genetic markers. Were looking for the genes for osteoporosis.

The other study, conducted by HSL investigators in collaboration with Boston University colleagues, took a GWAS approach to detecting genes related to longevity and aging traits. Two candidates are FOXO1a, which is associated with age at death, and PON1, which is associated with age at death and illness-free survival. These findings, if replicated in others studies, may help scientists understand better the mechanisms responsible for aging and, in turn, aid in health promotion and disease prevention.

The studies, published as part of a 17-paper supplement to the online, open-access journal BMC Medical Genetics, examined the genetic differences that potentially affect the risk for certain diseases, using data collected from the landmark Framingham Heart Study (FHS).

The studies evaluated DNA at 100,000 sites along the human genome where people are known to commonly differ. Researchers then looked for associations between the genotypes (the genetic makeup encoded in an individuals DNA) and hundreds of clinical phenotype measures (observable, physical characteristics) from nearly 60 years of FHS data, including biomarkers for cardiovascular disease, cancer, osteoporosis, longevity and aging, and renal and endocrine function, among others.

In addition to BMC Medical Genetics, the results of the studies are also available through an online database of genotypes and phenotypes (http://view/ncbi.nlm.nih.gov/dbgap), which provides a number of electronic enhancements for viewing and examining the data, such as enabling users to drill down for precise details on all associations and allowing the data to be explored in the context of other National Center for Biotechnology Information genomic resources.

It is important to remember, says David Karasik, Ph.D., an associate scientist at IFAR and co-author of the HSL papers, that we need to replicate our findings in other studies. We havent found the genes for osteoporosis and aging, but weve generated a hypothesis for future work.


'/>"/>

Contact: Scott Edwards
edwards@hrca.harvard.edu
617-363-8385
Hebrew SeniorLife Institute for Aging Research
Source:Eurekalert

Related biology news :

1. New protein discovered by Hebrew University researchers
2. Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher
3. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
4. A first -- Hebrew University scientist observes brain cell development in real time
5. Researchers discover way to make cells in the eye sensitive to light
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Researchers Uncover Key Step In Manufacture of Memory Protein
8. NYU researchers simulate molecular biological clock
9. Researchers reveal the infectious impact of salmon farms on wild salmon
10. Researchers identify target for cancer drugs
11. Vital step in cellular migration described by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... June 22, 2016   Acuant , ... verification solutions, has partnered with RightCrowd ® ... for Visitor Management, Self-Service Kiosks and Continuous ... that add functional enhancements to existing physical ... and venues with an automated ID verification ...
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... Seattle, WA (PRWEB) , ... June 23, 2016 ... ... technology, announces the release of its second eBook, “Clinical Trials Patient Recruitment and ... patient recruitment and retention in this eBook by providing practical tips, tools, and ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology: