Navigation Links
Hebrew SeniorLife researchers search for aging, osteoporosis genes
Date:9/20/2007

(Boston, Mass.) Researchers at Hebrew SeniorLifes Institute for Aging Research (IFAR) have examined close to 100,000 genetic markers for low bone mass and aging to help determine which genes are responsible for the development of osteoporosis and longevity.

One of the HSL studies surveyed the entire human genome (all the genetic material in a living organism), called a genome-wide association study (GWAS), to look for common genetic variations in hereditary osteoporosis traits, such as bone mineral density.

Weve examined nearly 100,000 genetic markers, says Douglas Kiel, M.D., M.P.H., director of medical research at IFAR and co-author of two of the papers, Were using this data and bone measurements over the years to see if bone mass is associated with certain genetic markers. Were looking for the genes for osteoporosis.

The other study, conducted by HSL investigators in collaboration with Boston University colleagues, took a GWAS approach to detecting genes related to longevity and aging traits. Two candidates are FOXO1a, which is associated with age at death, and PON1, which is associated with age at death and illness-free survival. These findings, if replicated in others studies, may help scientists understand better the mechanisms responsible for aging and, in turn, aid in health promotion and disease prevention.

The studies, published as part of a 17-paper supplement to the online, open-access journal BMC Medical Genetics, examined the genetic differences that potentially affect the risk for certain diseases, using data collected from the landmark Framingham Heart Study (FHS).

The studies evaluated DNA at 100,000 sites along the human genome where people are known to commonly differ. Researchers then looked for associations between the genotypes (the genetic makeup encoded in an individuals DNA) and hundreds of clinical phenotype measures (observable, physical characteristics) from nearly 60 years of FHS data, including biomarkers for cardiovascular disease, cancer, osteoporosis, longevity and aging, and renal and endocrine function, among others.

In addition to BMC Medical Genetics, the results of the studies are also available through an online database of genotypes and phenotypes (http://view/ncbi.nlm.nih.gov/dbgap), which provides a number of electronic enhancements for viewing and examining the data, such as enabling users to drill down for precise details on all associations and allowing the data to be explored in the context of other National Center for Biotechnology Information genomic resources.

It is important to remember, says David Karasik, Ph.D., an associate scientist at IFAR and co-author of the HSL papers, that we need to replicate our findings in other studies. We havent found the genes for osteoporosis and aging, but weve generated a hypothesis for future work.


'/>"/>

Contact: Scott Edwards
edwards@hrca.harvard.edu
617-363-8385
Hebrew SeniorLife Institute for Aging Research
Source:Eurekalert

Related biology news :

1. New protein discovered by Hebrew University researchers
2. Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher
3. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
4. A first -- Hebrew University scientist observes brain cell development in real time
5. Researchers discover way to make cells in the eye sensitive to light
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Researchers Uncover Key Step In Manufacture of Memory Protein
8. NYU researchers simulate molecular biological clock
9. Researchers reveal the infectious impact of salmon farms on wild salmon
10. Researchers identify target for cancer drugs
11. Vital step in cellular migration described by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... February 3, 2016 --> ... research report "Automated Fingerprint Identification System Market by Component ... Application (Banking & Finance, Government, Healthcare, and Transportation) and ... the market is expected to be worth USD 8.49 ... between 2015 and 2020. The transformation and technology evolution ...
(Date:2/3/2016)... 2016 http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ... "Emotion Detection and Recognition Market by ... Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020" report ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition of ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of the bioinformatic market by reviewing the recent ... enabled tools that drive the field forward. Includes ... to: Identify the challenges and opportunities that ... providers and software solution developers, as well as ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Buffalo, New York (PRWEB) , ... February 11, ... ... and analytical instruments for more than 150 years, continues today to pursue the ... to its line of analytical instruments: the AR9 Refractometer and the AR5 Refractometer. ...
(Date:2/10/2016)... , Feb. 10, 2016  The Maryland House ... , has announced that University of Maryland School of ... MBA and University of Maryland Medical System President and ... the "Speaker,s Medallion," the highest honor given to the ... Delegates. Dean Reece and Mr. Chrencik ...
(Date:2/10/2016)... Feb. 10, 2016  Allergan plc (NYSE: AGN ... Brent Saunders , Allergan,s CEO and President, will ... chat session at the RBC Capital Markets Healthcare Conference ... at The New York Palace Hotel in ... webcast live and can be accessed on Allergan,s Investor ...
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare Medical, ... and support program, Sonalinkā„¢ remote monitoring. The inaugural launch of this new technology ... 5th, connecting Dr. Samuel Peretsman to a HIFU technical expert at SonaCare Medical ...
Breaking Biology Technology: