Navigation Links
Hebrew SeniorLife researchers search for aging, osteoporosis genes
Date:9/20/2007

(Boston, Mass.) Researchers at Hebrew SeniorLifes Institute for Aging Research (IFAR) have examined close to 100,000 genetic markers for low bone mass and aging to help determine which genes are responsible for the development of osteoporosis and longevity.

One of the HSL studies surveyed the entire human genome (all the genetic material in a living organism), called a genome-wide association study (GWAS), to look for common genetic variations in hereditary osteoporosis traits, such as bone mineral density.

Weve examined nearly 100,000 genetic markers, says Douglas Kiel, M.D., M.P.H., director of medical research at IFAR and co-author of two of the papers, Were using this data and bone measurements over the years to see if bone mass is associated with certain genetic markers. Were looking for the genes for osteoporosis.

The other study, conducted by HSL investigators in collaboration with Boston University colleagues, took a GWAS approach to detecting genes related to longevity and aging traits. Two candidates are FOXO1a, which is associated with age at death, and PON1, which is associated with age at death and illness-free survival. These findings, if replicated in others studies, may help scientists understand better the mechanisms responsible for aging and, in turn, aid in health promotion and disease prevention.

The studies, published as part of a 17-paper supplement to the online, open-access journal BMC Medical Genetics, examined the genetic differences that potentially affect the risk for certain diseases, using data collected from the landmark Framingham Heart Study (FHS).

The studies evaluated DNA at 100,000 sites along the human genome where people are known to commonly differ. Researchers then looked for associations between the genotypes (the genetic makeup encoded in an individuals DNA) and hundreds of clinical phenotype measures (observable, physical characteristics) from nearly 60 years of FHS data, including biomarkers for c
'/>"/>

Contact: Scott Edwards
edwards@hrca.harvard.edu
617-363-8385
Hebrew SeniorLife Institute for Aging Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. New protein discovered by Hebrew University researchers
2. Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher
3. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
4. A first -- Hebrew University scientist observes brain cell development in real time
5. Researchers discover way to make cells in the eye sensitive to light
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Researchers Uncover Key Step In Manufacture of Memory Protein
8. NYU researchers simulate molecular biological clock
9. Researchers reveal the infectious impact of salmon farms on wild salmon
10. Researchers identify target for cancer drugs
11. Vital step in cellular migration described by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... 2015. The new marketing campaign is being spearheaded by ... Group ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ). ... retail driven marketing and brand awareness and has a ...
(Date:8/11/2015)... GOTHENBURG, Sweden , August 11, 2015 ... sensor FPC1155. Already received as well as expected revenues in 2015 ... included in FPC,s communicated revenue guidance of approximately 2,200 MSEK for ... is a prominent smartphone manufacturer ... ZUK selected FPC1 155 ...
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics Inc. ... human interface solutions, today announced collaboration with Microsoft ... Windows 10. Microsoft leveraged Synaptics, deep expertise in ... system. Through stringent testing, Synaptics, ... certified with Microsoft,s Precision TouchPad (PTP) specification empowering ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2
... The final agenda for the Conference on Cell Therapy ... is now available online at http://www.crf.org/celltherapy/the-conference/agenda . The ... the premier meeting dedicated to the evolving field of ... and vascular disease, as well as related diseases such ...
... Boulder, Colo., USA New Geology postings extend ... years; determine erosion rates for exposure of today,s ... pulses; call mudstones "so complicated as to almost ... the oldest rocks on Earth; postulate that biomarkers ...
... Philadelphia, PA, January 8, 2014 Food prepared away ... in nutrition than food prepared at home, but it ... purchased in the United States. Consumers tend to view ... fast-food restaurants, but some studies have found much higher ...
Cached Biology News:Final agenda available for CRF Conference on Stem Cell Therapy for Heart Disease 2Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 2Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 3Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 4Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 5Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 6Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 7Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 8Geological Society of America's top journal, Geology, begins 2014 with 10 new articles 9Nutrition guidelines needed for full-service restaurant chains 2
(Date:9/2/2015)... ... September 02, 2015 , ... ... of their entire waste to energy process and continue to contribute to the ... Upgrade , Temarry’s Waste to Energy process has been operating at their Mexico ...
(Date:9/2/2015)... ... September 02, 2015 , ... Genedata, a leading ... unveiled Genedata Screener ® version 13.0 at ELRIG Drug Discovery 2015. This ... a rich set of new capabilities. Screener now supports High Throughput Flow Cytometry ...
(Date:9/1/2015)... Carolina (PRWEB) , ... September 02, 2015 , ... ... released new features to its eCommerce site Spirax Sarco Anytime. This platform, offering ... Why wait to place your next order? Log on to Spirax Sarco Anytime ...
(Date:9/1/2015)... EDISON, N.J. , Sept. 1, 2015  ContraVir ... focused on the development and commercialization of targeted antiviral ... Rodman & Renshaw 17 th Annual Global Investment ... taking place September 8-10, 2015 at The St. Regis ... James Sapirstein , Chief Executive ...
Breaking Biology Technology:Temarry Recycling’s New $100,000 Waste to Energy Renovation 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 3New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 4Spirax Sarco Announces New Features to Anytime Platform 2ContraVir to Present at Rodman & Renshaw 17th Annual Global Investment Conference 2
... we talk all the time about Midwest technology workplaces in ... ,Could you qualify as a Midwest tech employee if you ... vendor? Yes, technically. After all, technology is so integrated into ... are online three seconds after the "bleep" noise from the ...
... Apple Records (of Beatles fame) is now headed for the ninth ... McCartney, with the title of a legendary musical artist and boyish ... youthful boy wonder, Steve Jobs with his intellect and a legendary ... personal computer revolution. , ,The fight is all about the name ...
... The first is that any mildly successful software program will ... system. Thats a topic for another column. The second is ... software that its designers never imagined. , ,EBays recent experience ... Half.com intending to shut it down and move its users ...
Cached Biology Technology:You might work in a Midwest technology environment if... 2You might work in a Midwest technology environment if... 3Why you should never name your company after a fruit 2Why you should never name your company after a fruit 3Byron's laws of software 2Byron's laws of software 3