Navigation Links
Heavy pyridine crystallizes differently
Date:1/8/2009

This release is available in German.

The nuclei of ordinary hydrogen atoms contain only a single proton. If a neutron is added, the hydrogen becomes deuterium. In principle, molecules that contain deuterium in place of hydrogen atoms are chemically identical. However, there can be significant differences. Thus "heavy water", water with molecules that contain deuterium in place of hydrogen, is toxic because it disrupts highly sensitive biochemical processes in the body and leads to metabolic failure. As researchers report in the journal Angewandte Chemie, when the hydrogen atoms of pyridine are replaced with deuterium, it adopts a crystalline form that can only be achieved under high pressure with "normal" pyridine. Perhaps the minimal differences responsible for this type of effect can be implemented to improve the spectrum of properties available to pharmaceutical agents.

Pyridine is a six-membered ring with five carbon atoms and one nitrogen atom. The carbon atoms are each attached to one hydrogen atom. These can be replaced with deuterium. Researchers led by Roland Boese at the University of DuisburgEssen have discovered that deuterated pyridine crystallizes at about -85 C with a different crystal structure than that usually adopted by pyridine. In parallel, British researchers working with Simon Parsons determined that non-deuterated pyridine also adopts this structure under high pressure, because it occupies a smaller volume than pyridine's usual structure.

The replacement of hydrogen by deuterium clearly changes the strength of interactions between individual groups of atoms in neighboring molecules, making other arrangements more energetically favorable. Such interactions between groups of atoms also play an important role in pharmaceuticals, such as when a drug is meant to fit into the binding cavity of an enzyme. Subtle changes can result in significant changes in a drug's activity. This is why Boese and his team are interested in deuterated pyridine: pyridine is an important starting material for pharmaceuticals, and its basic framework is found in many medications. Boese thinks it likely that deuteration will allow for the development of drug variants that are more specific or have fewer side effects than their conventional precursors.


'/>"/>

Contact: Roland Boese
roland.boese@uni-due.de
49-201-183-2416
Wiley-Blackwell
Source:Eurekalert  

Related biology news :

1. Heavy rainfall on the increase
2. Heavy metals in the Peak District -- evidence from bugs in blanket bogs
3. Alzheimers starts earlier for heavy drinkers, smokers
4. Heavy metal link to mutations, low growth and fertility among crustaceans in Sydney Harbor tributary
5. Gaining too much weight during pregnancy nearly doubles risk of having a heavy baby
6. Plants can be used to study how and why people respond differently to drugs
7. Breast cancers behave differently before and after the age of 70
8. Nitrous oxide emissions respond differently to no-till depending on the soil type
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heavy pyridine crystallizes differently
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
(Date:1/28/2016)... Jan. 28, 2016 Synaptics (NASDAQ: SYNA ), a ... its second quarter ended December 31, 2015. ... of fiscal 2016 increased 2 percent compared to the comparable quarter ... of fiscal 2016 was $35.0 million, or $0.93 per diluted share. ... income for the first quarter of fiscal 2016 grew 9 percent ...
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... , ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their new ... San Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS Expo ... PIN diode standard packages feature a TO-46 metal can with active areas of 1.0mm ...
(Date:2/10/2016)... ... February 10, 2016 , ... PatientCrossroads announces that ... secure online PatientCrossroads platform, has exceeded both its one-year and overall recruitment goals ... study, which seeks to advance understanding of the hereditary risks for certain kinds ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... announced a new agreement with Singapore-based Global Stem Cells Network (GSCN) and its ... Thailand and Singapore in the latest adipose and bone marrow therapies. , ...
(Date:2/10/2016)... (PRWEB) , ... February 09, 2016 , ... ... services and current winner of the Highest Overall Customer Rating Award from ... all of its business units across the USA, Canada, Mexico and China. , ...
Breaking Biology Technology: