Navigation Links
Hearing loss study reveals role of bone hardness in tissue function
Date:11/17/2010

scovered that TGF-β regulates Runx2 to establish the physical property of the extracellular matrix of the cochlea bone. "This told us," said Chang, "that Runx2 -- a key transcriptional regulator that helps the cell selects its cell fate -- also controls the physical properties of the matrix."

Finally, by manipulating Runx2 activity through TGF-β, the team determined that the physical quality of the bone matrix affects hearing.

Now, the team is investigating the molecules "downstream" of Runx2, to gain further insight into the mechanism regulating the physical properties of bone. They also are studying if these mechanisms define the stiffness of matrices in other skeletal tissues.

"We want to see if TGF-β targets the cartilage transcription factor to make cartilage more or less stiff," Alliston said. "We think that the stiffness is degraded in arthritis and that this further disrupts chondrocyte cells, exacerbating the disease."


'/>"/>

Contact: Jennifer O'Brien
jennifer.obrien@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Hearing colors, seeing sounds: New research explores sensory overlap in the brain
2. Scientists closer to grasping how the brains hearing center spurs responses to sound
3. Squid studies provide valuable insights into hearing mechanisms
4. Autism Speaks on US Senate hearing on potential environmental health factors in autism
5. NY state the focus of Congressional hearing on how research and innovation fuel local economies
6. Research reveals that temporary hearing deprivation can lead to lazy ear
7. Gene linked to a rare form of progressive hearing loss in males is identified
8. Escaped proteins add to hearing loss in elderly, UF researchers find
9. Hearing on the wing: New structure discovered in butterfly ears
10. Gene discovery reveals a critical proteins function in hearing
11. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... struggle to deal with ever-growing piles of electronic waste ... just how much there is and where it really ... Science & Technology , their study found that nearly ... into just seven developing countries with major potential ... Knut Breivik and colleagues note that the export from ...
(Date:7/23/2014)... HOLE, MA -- What do mollusks, starfish, and ... marine habitat, they are all calcifiersorganisms that use ... skeletons and shells for stability and protection. , ... , published by the Marine Biological Laboratory, addresses ... composition changes worldwide. , As atmospheric carbon dioxide ...
(Date:7/23/2014)... getting tangled and forming knots. Scientists study these knots ... them (e.g. useful for gene sequencing techniques). Cristian Micheletti, ... in Trieste and his team have been carrying out ... dynamics. In their latest paper, just published in the ... Di Stefano, first author and PhD student at SISSA, ...
Breaking Biology News(10 mins):Calcification in changing oceans explored in special issue of The Biological Bulletin 2
... the oocysts from the Cryptosporidium genus and cysts ... greatest public health problems in water supply, because these parasites ... Hermida, a scientist at the Galician Institute for Food Quality ... A team led by this researcher took 232 water samples ...
... NextCAT Inc., a Detroit-based company, announced that it has ... developed at the National Biofuels Energy Lab at Wayne ... NextCAT to commercialize a class of catalysts that enable ... waste vegetable oil, animal fats and residual corn oil, ...
... named Brontomerus mcintoshi , or "thunder-thighs" after its enormously powerful ... is described in a paper recently published in the journal ... the U.K. and the U.S. A member of the ... Brachiosaurus , Brontomerus may have used its powerful ...
Cached Biology News:Parasitic protozoons survive waste water and drinking water treatment plants in Galicia 2NextCAT secures license agreement for advanced biofuel technology from Wayne State 2New 'thunder-thighs' dinosaur discovered 2New 'thunder-thighs' dinosaur discovered 3
(Date:7/23/2014)... and Russian Quantum Center at Skolkovo) and Mario ... the Institute of Physics in Bratislava, Slovakia) have ... particles passing through an amplifier and, conversely, when ... provided in an article published in the journal ... Quantum entangled particles are considered to be the ...
(Date:7/23/2014)... ANGELES , July 23, 2014 /PRNewswire-iReach/ -- Think ... cognitive performance for the long term. They are the ... edge of sustained energy as an alternative to the ... Think Drinks on Indiegogo on July 29, 2014, with ... 30-day campaign. Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... Columbia, MD (PRWEB) July 23, 2014 ... Station, an LC/MS amino acid analysis system developed ... analysis, the UF-Amino Station can analyze 38 amino ... , The UF-Amino Station achieves high-speed analysis utilizing ... spectrometer. The LCMS-2020 provides accurate analytical results even ...
(Date:7/23/2014)... 23, 2014  Having the right people at the ... accelerating business growth and achieving clinical and operational goals. ... Leadership Summit, July 20-22, 2014, in San ... executives and healthcare experts discussing how partnerships have positively ... President & Chief Executive Officer of Cape Regional Medical ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2Shimadzu's New UF-Amino Station Provides High-Speed, Multi-Component Analysis of Amino Acids in Food & Beverage and Pharmaceutical Testing 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2
... pfuturbo DNA polymerase for robust, high-fidelity PCR,amplification ... Valerie,Hedden Connie Hansen Janice Cline Frances ... ,Stratagene , Stratagene announces the release of pfuturbo DNA ... for high-fidelity,PCR. PfuTurbo DNA polymerase is a blend ...
... One-column protein purification and native eukaryotic amino ... Lu John Bauer ,Stratagene Cloning Systems, ... expression system features rapid and high-yield,production of ... cloning (LIC) for efficient and directional cloning ...
... Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins ,,,,, ... Sensitive, and Rapid Detection of FLAG -Tagged,Fusion ... Hosfield Peter Pingerelli, Weiping Yang ,Stratagene , Stratagenes TagDetect ... , is an easy-to-use assay kit for detecting ...
Cached Biology Technology:Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 2Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 3Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 4Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 5Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 6Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 7Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 8Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 9Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 10Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 11New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 2New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 3New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 4New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 5Simple, Sensitive, and Rapid Detection of FLAG -Tagged,Fusion Proteins 2Simple, Sensitive, and Rapid Detection of FLAG -Tagged,Fusion Proteins 3Simple, Sensitive, and Rapid Detection of FLAG -Tagged,Fusion Proteins 4
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
... General description: Compatible with AutoGen AutoGenesys, ... high volume automated colony picking systems This ... created to easily match Cornings product number. ... under the old Sigma-Aldrich number (D9314) or ...
... provides a positive selection for creating baculovirus ... in insect cells. The kit improves on ... by eliminating the time-consuming steps of plaque ... genome with a portion of the essential ...
Biology Products: