Navigation Links
Healthy or diseased?
Date:7/2/2008

This release is available in German.

Metabolomics aims to determine the totality of all small molecules of a cell or a tissue. The exponents of bioinformatics analyzed data collected in the framework of a pre-clinical metabolomics study in healthy and diabetic mice. In each case, a subgroup of the animals was treated with the diabetes drug RoziglitazoneTM. Then, more than 800 metabolites were quantitatively determined in a blood plasma sample of a total of forty mice, representing the factors "healthy/diabetic" and "treated/untreated".

Karsten Suhre, who led the work at the Helmholtz Zentrum Mnchen, explains the results: "It transpired that in many cases the ratios between the concentrations of certain metabolites were much more informative than their absolute concentrations." By a subsequent clustering of the test statistics of such metabolite pairs, it is possible to identify groups of metabolites which discriminate the animals by the factors "healthy/diabetic" or "treated/untreated".

The present results show that diabetes-biomarkers can be identified by means of an objective bioinformatics analysis of complex metabolomics data obtained in high-throughput experiments. Suhre added: "This bioinformatics approach can be used, in conjunction with the new metabolomics technology platform (metaP) at the HelmholtzZentrum mnchen, for the automatic identification of groups of relevant biomarkers of disease. Additionally, with the pre-clinical investigation of the effect of new drugs, metabolomics permits for the early identification of possible side effects on the metabolism.

Hitherto, genetic methods and/or transcription analyses stood rather to the fore in the investigation of metabolic diseases. Now, advances in the area of mass spectroscopy allow for the extensive examination of the metabolome. "With this recent quantum leap in the area of metabolite analysis, the challenge to bioinformatics is to develop customized, numerical evaluation methods to handle the complexity of these high quantity metabolomic data sets", explains Karsten Suhre.


'/>"/>

Contact: Karsten Suhre
karsten.suhre@helmholtz-muenchen.de
49-893-187-2627
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related biology news :

1. Caloric intake negatively influences healthy adults sleep patterns
2. Fat intake negatively influences the sleep pattern in healthy adults
3. Study finds healthy intestinal bacteria within chicken eggs
4. Healthy parents provide clues to survival of young haddock on Georges Bank
5. Crop management strategies key to a healthy Gulf, planet
6. Macadamia nuts can be included in heart healthy diet
7. U of M research finds teens who have TV in their bedroom are less likely to engage in healthy habits
8. Healthy rivers needed to remove nitrogen
9. Iowa Staters talk biofuels, healthy oils and pharma crops at AAAS meeting
10. Want healthy gums? Hit the dairy aisle
11. Insect gut detects unhealthy meal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/19/2016)... DUBAI , UAE, April 20, 2016 ... can be implemented as a compact web-based "all-in-one" system ... in the biometric fingerprint reader or the door interface ... requirements of modern access control systems. The minimal dimensions ... the ID readers into the building installations offer considerable ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... San Diego, CA (PRWEB) , ... April 29, 2016 , ... ... Cell Foundation (NSCF) to support the development of a patient-specific stem cell therapy for ... Bratt-Leal in the lab of Dr. Jeanne Loring at The Scripps Research Institute in ...
(Date:4/28/2016)... ... April 28, 2016 , ... Connecticut Innovations ... growing companies, today announced the launch of VentureClash , a $5 million ... , “VentureClash looks to attract the best early-stage companies here in Connecticut, ...
(Date:4/27/2016)... ... 2016 , ... Shimadzu Scientific Instruments (SSI) will be showcasing ... Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for ... stop by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... to announce the appointment of John Tilton as Chief Commercial Officer.  Mr. Tilton ... one of the founding commercial leaders responsible for the commercialization of multiple orphan ...
Breaking Biology Technology: