Navigation Links
Healthy or diseased?
Date:7/2/2008

This release is available in German.

Metabolomics aims to determine the totality of all small molecules of a cell or a tissue. The exponents of bioinformatics analyzed data collected in the framework of a pre-clinical metabolomics study in healthy and diabetic mice. In each case, a subgroup of the animals was treated with the diabetes drug RoziglitazoneTM. Then, more than 800 metabolites were quantitatively determined in a blood plasma sample of a total of forty mice, representing the factors "healthy/diabetic" and "treated/untreated".

Karsten Suhre, who led the work at the Helmholtz Zentrum Mnchen, explains the results: "It transpired that in many cases the ratios between the concentrations of certain metabolites were much more informative than their absolute concentrations." By a subsequent clustering of the test statistics of such metabolite pairs, it is possible to identify groups of metabolites which discriminate the animals by the factors "healthy/diabetic" or "treated/untreated".

The present results show that diabetes-biomarkers can be identified by means of an objective bioinformatics analysis of complex metabolomics data obtained in high-throughput experiments. Suhre added: "This bioinformatics approach can be used, in conjunction with the new metabolomics technology platform (metaP) at the HelmholtzZentrum mnchen, for the automatic identification of groups of relevant biomarkers of disease. Additionally, with the pre-clinical investigation of the effect of new drugs, metabolomics permits for the early identification of possible side effects on the metabolism.

Hitherto, genetic methods and/or transcription analyses stood rather to the fore in the investigation of metabolic diseases. Now, advances in the area of mass spectroscopy allow for the extensive examination of the metabolome. "With this recent quantum leap in the area of metabolite analysis, the challenge to bioinformatics is to develop customized, numerical evaluation methods to handle the complexity of these high quantity metabolomic data sets", explains Karsten Suhre.


'/>"/>

Contact: Karsten Suhre
karsten.suhre@helmholtz-muenchen.de
49-893-187-2627
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related biology news :

1. Caloric intake negatively influences healthy adults sleep patterns
2. Fat intake negatively influences the sleep pattern in healthy adults
3. Study finds healthy intestinal bacteria within chicken eggs
4. Healthy parents provide clues to survival of young haddock on Georges Bank
5. Crop management strategies key to a healthy Gulf, planet
6. Macadamia nuts can be included in heart healthy diet
7. U of M research finds teens who have TV in their bedroom are less likely to engage in healthy habits
8. Healthy rivers needed to remove nitrogen
9. Iowa Staters talk biofuels, healthy oils and pharma crops at AAAS meeting
10. Want healthy gums? Hit the dairy aisle
11. Insect gut detects unhealthy meal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it ... Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks Associates ... will speak at the TMA 2017 Annual Meeting , October 11 ... in the residential home security market and how smart safety and security ... Parks Associates: ... "The residential security ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions to ... symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory science, ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
Breaking Biology Technology: