Navigation Links
Health benefits, consequences of folic acid dependent on circumstances
Date:4/1/2009

Boston, MA and Washington, D.C.April 1, 2009For the past several decades, evidence has shown that greater dietary intake of the B-vitamin, folate, offers protection against the development of certain common cancers and reduces neural tube defects in newborns, opening new avenues for public health interventions that have a great impact on health. However, folate's central role as an essential factor in DNA synthesis also means that abundant availability of the vitamin can enhance the development of pre-cancerous and cancerous tumors. Further, the intake of folic acid that results from consuming foods that are voluntarily fortified (e.g.: ready-to-eat cereals) in combination with the additional intake received from mandatory fortification of flour means that supplementary intake of folic acid is unnecessary for many segments of the population, and may even present a risk. Nevertheless, the issue is a complicated one since women of child-bearing age seem to benefit from supplemental folic acid in regard to its protection against birth defects. In the April issue of the journal Nutrition Reviews, two new articles by Omar Dary, Ph.D., and Joel B. Mason, M.D., assess the conditions under which folic acid can be beneficial and harmful and contribute to guidelines for the healthful intake of folic acid as a complement to dietary folate.

The consequences of inadequate folate intake remain prevalent in many countries, even in industrial countries where specific interventions of folic acid have not been implemented. Moreover, there continues to be some concernwhich, to date, lacks compelling scientific evidencethat the synthetic form of the vitamin, folic acid, might have adverse effects that do not exist with natural sources of folate.

Under most circumstances, adequate intake of folate appears to assume the role of a protective agent against cancer, most notably colorectal cancer. However, in select circumstances in which an individual who harbors a pre-cancerous or cancerous tumor consumes too much folic acid, the additional amounts of folate may instead facilitate the promotion of cancer. In countries in which the fortification of flour with folic acid is working well, additional supplementation in the form of vitamin pills can lead to excessive intakes of the vitamin, which can then have undesirable adverse effects.

Thus, folate appears to assume different guises depending on the circumstances. The level of intake of this micronutrient that is safe for one person may be potentially harmful to another.

"These effects of folate on the risk of developing cancer have created a global dilemma in the efforts to institute nationwide folic acid fortification programs around the world," Mason notes.

Most individuals in the U.S. population are now folate-replete, so one consideration would be to reduce the doses of the vitamin that are present in most over-the-counter supplements. Many people receive sufficient amounts of folate through their diet.

Now that the supply of folic acid in the diet is much larger than it was prior to mandatory fortification, food policies may need to be adjusted to the current knowledge and the new circumstances.

"The design of cogent public health policies that effectively optimize health for many while presenting no or minimal risk to others, must often occur in the absence of complete information," Mason concludes. "However, we are nevertheless obliged to deliberate with as much of an in-depth understanding as the existing science allows."


'/>"/>

Contact: Amy Molnar
professionalnews@bos.blackwellpublishing.net
201-748-8844
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
2. Youre likely to order more calories at a healthy restaurant
3. UC health news: molecular pathway may predict chemotherapy effectiveness
4. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
5. UCR engineers to develop new tool to measure how environmental exposures affect health
6. Researchers developing device to predict proper light exposure for human health
7. Thousands of starving children could be restored to health with peanut butter program
8. Smithsonian researchers develop models to assess wetland health
9. AIBS to cohost symposium on evolution, disease and human health
10. NASA celebrates a decade observing climate impacts on health of worlds oceans
11. Conference to examine role technology can play in helping US manage healthcare costs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
Breaking Biology News(10 mins):
(Date:8/18/2017)... , ... August 18, 2017 , ... ... Equipment for the Semiconductor, MEMS, and Microfluidics Industries, announces the new Model 800E ... found more often in automated production mask aligners. OAI has already received ...
(Date:8/16/2017)... Arizona (PRWEB) , ... August ... ... proud to introduce the Fluidnatek® Electrospinning and Electrospraying ... electrospraying equipment scales from table-top equipment for the lab to fully automated ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... Food and Drug Administration (FDA) inspection at our Dilworth, MN site. The inspection ... issued. This inspection was conducted as part of a routine Bioresearch Monitoring Program ...
(Date:8/15/2017)... ... 2017 , ... Kapstone Medical is proud to announce that it ... companies and inventors develop and safeguard their latest innovations. The company has grown ... portfolio of clients in the United States and around the world. , Company ...
Breaking Biology Technology: