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Having first-degree relative with atrial fibrillation linked with increased risk
Date:11/13/2010

siblings (n = 404). Among participants with familial AF, the number of affected relatives ranged from 1 to 5.

The researchers found that AF occurred more frequently (approximately 40 percent increased risk) among participants with familial AF than without familial AF (unadjusted absolute event rates of 5.8 percent and 3.1 percent, respectively). The association was not weakened by adjustment for AF risk factors or reported AF-related genetic variants. Atrial fibrillation risk was associated with increasing number of affected first-degree relatives.

Assessment of premature familial AF was associated with a very slight increase in predictive accuracy compared with traditional risk factors.

"Future efforts should attempt to discern the factors that mediate the association between familial AF and AF risk, further explore the relationships between premature familial AF and risk prediction, and determine whether incorporating genetic variants into an AF prediction model enhances its performance," the authors conclude.


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Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8491
JAMA and Archives Journals
Source:Eurekalert

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