Navigation Links
Having first-degree relative with atrial fibrillation linked with increased risk
Date:11/13/2010

An examination of the heritability of atrial fibrillation (AF) among more than 4,000 participants in the Framingham Heart Study finds the occurrence of AF in first-degree relatives was associated with AF risk after adjustment for established AF risk factors and AF-related genetic variants, according to a study that will appear in the November 24 issue of JAMA. The study is being released early online because it will be presented at the American Heart Association's annual meeting.

"A heritable component underlying atrial fibrillation has been well demonstrated, and it is now evident that genetic variants are associated with AF risk," the investigators write. However, the contribution of familial AF (defined in this study as the occurrence of AF in a first-degree relative prior to an examination commencing an 8-year follow-up period) to predicting new-onset AF remains unknown.

Steven A. Lubitz, M.D., M.P.H., of the Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Mass., and colleagues examined the association between AF occurrence in a first-degree relative and AF risk and hypothesized that considering familial AF would improve prediction of new-onset AF. Participants were from the Framingham Heart Study, a prospective community-based cohort study started in 1948. Original and offspring participants were at least 30 years of age, free of AF at the beginning of the study, and had at least 1 parent or sibling enrolled in the study. The 4,421 participants in this analysis (average age, 54 years; 54 percent women) were followed up through December 2007.

During the period 1968-2007, 440 participants developed AF. Familial AF occurred among 1,185 participants (26.8 percent) and premature familial AF (onset 65 years of age or younger) occurred among 351 participants (7.9 percent). Of the 2,393 baseline examinations at which familial AF was present, sources included fathers (n = 1,163), mothers (n = 1,068), and siblings (n = 404). Among participants with familial AF, the number of affected relatives ranged from 1 to 5.

The researchers found that AF occurred more frequently (approximately 40 percent increased risk) among participants with familial AF than without familial AF (unadjusted absolute event rates of 5.8 percent and 3.1 percent, respectively). The association was not weakened by adjustment for AF risk factors or reported AF-related genetic variants. Atrial fibrillation risk was associated with increasing number of affected first-degree relatives.

Assessment of premature familial AF was associated with a very slight increase in predictive accuracy compared with traditional risk factors.

"Future efforts should attempt to discern the factors that mediate the association between familial AF and AF risk, further explore the relationships between premature familial AF and risk prediction, and determine whether incorporating genetic variants into an AF prediction model enhances its performance," the authors conclude.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8491
JAMA and Archives Journals
Source:Eurekalert

Related biology news :

1. Women with diabetes having more C-sections and fetal complications: study
2. Caltech researchers obtain first brain recordings from behaving fruit flies
3. Womens soccer -- get fit while having fun
4. Immigrant women may be at higher risk of having a baby with a birth defect
5. Gaining too much weight during pregnancy nearly doubles risk of having a heavy baby
6. UF to help sequence genome of flowering plants ancient living relative
7. Gulf oil dispersants unlikely to be endocrine disruptors and have relatively low cell toxicity
8. New book reviews research on p53 -- the guardian of the genome -- and its relatives
9. UF researchers: Ancient crocodile relative likely food source for Titanoboa
10. Comprehensive look at rare leukemia finds relatively few genetic changes launch disease
11. Gene decides whether coral relative will fuse or fight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... Calif. , Nov. 14, 2016 /PRNewswire/ ... biometric identification market, Frost & Sullivan recognizes ... & Sullivan Award for Visionary Innovation Leadership. ... in the biometric identification market by pioneering ... verification solution for instant, seamless, and non-invasive ...
(Date:6/22/2016)... , June 22, 2016  The American College of ... Trade Show Executive Magazine as one of the fastest-growing ... May 25-27 at the Bellagio in Las Vegas ... the highest percentage of growth in each of the following ... exhibiting companies and number of attendees. The 2015 ACMG Annual ...
(Date:6/22/2016)... June 22, 2016 On Monday, the Department ... industry to share solutions for the Biometric Exit Program. ... and Border Protection (CBP), explains that CBP intends to ... the United States , in order ... defeat imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... ... automation and IT solutions, today announced the company has successfully completed its 50th ... executed automation and control systems integration services to leading companies in life sciences, ...
(Date:12/6/2016)... , Dec. 6, 2016 Zimmer Biomet Holdings, ... announced the pricing terms of its previously-announced cash ... aggregate purchase price (excluding accrued and unpaid interest ... and excluding fees and expenses related to the ... securities identified in the table below (collectively, the ...
(Date:12/5/2016)... -- Axovant Sciences Ltd. (NYSE: AXON ), ... of dementia, today announced that data on the investigational ... will be presented at the 2016 Clinical Trials in ... in San Diego . Intepirdine presentations ... complex measures of activities of daily living (ADLs) and ...
(Date:12/5/2016)... 5, 2016 According to ... by Products (Consumable, Instruments, Automated Cell Expansion System), ... Stem Cell Research, Cancer, and Cell-Based Research), End-users ... - Global Revenue, Trends, Growth, Share, Size and ... the global cell expansion market is expected to ...
Breaking Biology Technology: