Navigation Links
Harvard researchers publish MRI images of genes in action in the living brain
Date:3/30/2008

Biologists have just confirmed what poets have known for centuries: eyes really are windows of the soulor at least of the brain. In a new study published in the April 2008 print issue of The FASEB Journal (http://www.fasebj.org), Harvard researchers describe the development of gene probe eye drops thatfor the first timemake it possible to monitor and detect tissue repair in the brain of living organisms using MRI. Current methods involve a risky, invasive, and relatively slow process of penetrating the skull to extract tissue samples and then examining those samples in a laboratory.

We hope our study provides a tool for better treatments of neurological diseases, diagnosis, prognosis during therapy, and improved delivery of therapeutic agents to the brain, said Philip Liu of Harvard, one of the researchers involved in the study. Liu also said that more research is necessary to determine exactly how these gene probes reach brain tissue.

In this report, Harvard researchers describe how they link a relatively common MRI probe (superparamagnetic iron oxide nanoparticles) to a short DNA sequence that binds to proteins in cells responsible for brain tissue repair (glia and astrocytes). Then, researchers used the eye drops on mice with conditions that cause leaks in the blood-brain barrier. When the animals brains were scanned using MRI, brain repair activity was visible. Glia and astrocytes help repair brain and nerve tissue, and have a role in numerous diseases and disorders that cause at least microscopic breaches in the blood-brain barrier, including traumatic brain injury, multiple sclerosis, stroke, cardiac arrest, and glioma, among others. Furthermore, the researchers believe that the probes may also help diagnose thinning of vascular walls in brains, which occurs as Alzheimers disease progresses.

When people are sick, the last thing you want to do is puncture their skulls for a biopsy, said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, but sometimes this is unavoidable. These probes of genes in action go a long way toward ushering in an age where extracting brain tissue to identify a disease will seem as crude as when doctors measured skulls to diagnose a mental disease.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert  

Related biology news :

1. BASF and Harvard University announce extensive research collaboration
2. Researchers use high tech in mold watermark to protect plastic products from piracy
3. Womens health-related scientific findings presented by University of Pittsburgh researchers
4. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
5. Yerkes researchers identify language feature unique to human brain
6. Stanford researchers developing 3-D camera with 12,616 lenses
7. 19 researchers selected as 2008 Leopold Leadership Fellows
8. Researchers discover how stealthy HIV protein gets into cells
9. Researchers at Stockholm University awarded the Descartes prize
10. Wisconsin researchers describe how digits grow
11. Antarcticas coldest, darkest season draws Montana State University researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harvard researchers publish MRI images of genes in action in the living brain
(Date:3/21/2016)... , March 22, 2016 ... recognition with passcodes for superior security   ... a leading provider of secure digital communications services, today ... biometric technology and offer enterprise customers, particularly those in ... facial recognition and voice authentication within a mobile app, ...
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s Board of ... 2016 in San Francisco. Located at booth number 7301, representatives from the Thai ... and discuss the Thai biotechnology and life sciences sector. , Deputy Secretary ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on ... that Charles W. Stellar has been named by the WEDI Board of Directors as ... As an executive leader with more than 35 years of experience in healthcare, association ...
(Date:5/24/2016)... , ... May 24, 2016 , ... Last week, Callan ... corporate executives and entrepreneurs, held The Future of San Diego Life Science event at ... Diego life science community attended the event with speakers Dr. Rich Heyman, former CEO ...
(Date:5/23/2016)... -- Oxitec CEO Hadyn Parry will ... ET before the United States House Committee on Science, Space ... in controlling the spread of the Aedes aegypti ...      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) Oxitec has ... Trials in Brazil , Panama ...
Breaking Biology Technology: