Navigation Links
Harvard researchers publish MRI images of genes in action in the living brain
Date:3/30/2008

Biologists have just confirmed what poets have known for centuries: eyes really are windows of the soulor at least of the brain. In a new study published in the April 2008 print issue of The FASEB Journal (http://www.fasebj.org), Harvard researchers describe the development of gene probe eye drops thatfor the first timemake it possible to monitor and detect tissue repair in the brain of living organisms using MRI. Current methods involve a risky, invasive, and relatively slow process of penetrating the skull to extract tissue samples and then examining those samples in a laboratory.

We hope our study provides a tool for better treatments of neurological diseases, diagnosis, prognosis during therapy, and improved delivery of therapeutic agents to the brain, said Philip Liu of Harvard, one of the researchers involved in the study. Liu also said that more research is necessary to determine exactly how these gene probes reach brain tissue.

In this report, Harvard researchers describe how they link a relatively common MRI probe (superparamagnetic iron oxide nanoparticles) to a short DNA sequence that binds to proteins in cells responsible for brain tissue repair (glia and astrocytes). Then, researchers used the eye drops on mice with conditions that cause leaks in the blood-brain barrier. When the animals brains were scanned using MRI, brain repair activity was visible. Glia and astrocytes help repair brain and nerve tissue, and have a role in numerous diseases and disorders that cause at least microscopic breaches in the blood-brain barrier, including traumatic brain injury, multiple sclerosis, stroke, cardiac arrest, and glioma, among others. Furthermore, the researchers believe that the probes may also help diagnose thinning of vascular walls in brains, which occurs as Alzheimers disease progresses.

When people are sick, the last thing you want to do is puncture their skulls for a biopsy, said Ge
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert  

Page: 1 2

Related biology news :

1. BASF and Harvard University announce extensive research collaboration
2. Researchers use high tech in mold watermark to protect plastic products from piracy
3. Womens health-related scientific findings presented by University of Pittsburgh researchers
4. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
5. Yerkes researchers identify language feature unique to human brain
6. Stanford researchers developing 3-D camera with 12,616 lenses
7. 19 researchers selected as 2008 Leopold Leadership Fellows
8. Researchers discover how stealthy HIV protein gets into cells
9. Researchers at Stockholm University awarded the Descartes prize
10. Wisconsin researchers describe how digits grow
11. Antarcticas coldest, darkest season draws Montana State University researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harvard researchers publish MRI images of genes in action in the living brain
(Date:7/25/2014)... WA Nearly 600 scientists from 25 countries ... Genetics Meeting organized by the Genetics Society of ... Washington in Seattle. The conference will feature close ... research results on topics including gene expression and ... emerging technologies, evolution, aging, and a variety of ...
(Date:7/25/2014)... congenital central nervous system disease that is caused ... during the embryonic phase. Many patients have varying ... neurocognitive retardation. Such problems decrease the patients, functional ... Ankara Physical Medicine and Rehabilitation Education and Research ... with SB, using the Pediatric Evaluation of Disability ...
(Date:7/25/2014)... the first time, Spanish researchers have detected an unknown ... cells are introduced into a droplet of salt ... sodium chloride crystallisation to create biomineralogical biosaline 3D morphologically ... the material, bacteria are revived. The discovery was made ... the cover of the Astrobiology journal and ...
Breaking Biology News(10 mins):Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2Bacteria manipulate salt to build shelters to hibernate 2
... journal Genetics this month, neurobiologist Dan Chase and ... experimental technique they developed that will allow scientists to study ... a living organism. The advance should allow deeper ... get a true understanding of what that single protein does ...
... DC The Microbial Diversity Course at the Marine Biological ... Milestones in Microbiology site by the American Society for ... recognizes institutions and the scientists who worked there that ... microbiology. A ceremony unveiling the plaque that will ...
... AT&T * and NEC Corporation of America ... among ruggedized 4G LTE smartphones , the NEC ... with AT&T Enhanced Push-to-Talk (EPTT)**, NEC Terrain ... aimed at breaking productivity barriers to keep workforces moving ...
Cached Biology News:UMass Amherst researchers develop powerful new technique to study protein function 2UMass Amherst researchers develop powerful new technique to study protein function 3Microbial diversity course designated as a 'Milestones in Microbiology' site 2AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 2AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 3AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 4AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 5
(Date:7/25/2014)... Pittsburgh, PA (PRWEB) July 25, 2014 ... annual Call for Topics for Conferee Networking. These two-hour ... similar interests to meet and resolve problems, discuss new ... , The deadline to submit a topic for consideration ... at pittcon.org . The Conferee Networking committee will ...
(Date:7/25/2014)... Israel , July 25, 2014  Galmed Pharmaceuticals ... biopharmaceutical company focused on the development and commercialization of ... diseases and cholesterol gallstones, today announced financial results for ... Half 2014 Financial Summary: , Reported cash and ... compared with $137,000 at December 31, 2013.  , ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 At the ... has granted a 60-day extension for the public comment ... Special Rule for Model Aircraft established by Congress as ... 2012. The 60-day extension establishes the new deadline for ... States Department of Transportation/FAA notice published in the Federal ...
(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
Breaking Biology Technology:Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6FAA Grants Comment Extension at the Request of AMA 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4
... - In a value-added move aimed at media-savvy ... social computing craze, Sonic Foundry has ... its Mediasite web communications product. , ,The ... a Madison-based rich media company, calls Mediasite Podcast. ...
... for the next wave of high-growth investments, and judging by ... range of opportunities await later-stage institutional investors. , ,In its ... Venture Research at the University of New Hampshire ... in 2006, with total investments of $25.6 billion. , ...
... yet to turn a profit, and it operates in a biotech ... by Madison research tool manufacturer NimbleGen Systems to file ... the latest bit of evidence that the Wisconsin biotech company is ... of growth and visibility for NimbleGen, which saw its revenues grow ...
Cached Biology Technology:National angel investment grew 11 percent in `06 2National angel investment grew 11 percent in `06 3IPO-bound NimbleGen traveling in fast company 2IPO-bound NimbleGen traveling in fast company 3IPO-bound NimbleGen traveling in fast company 4
...
Goat polyclonal to Rabenosyn 5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: ELKHTLAKQKGGTD, corresponding to C terminal amino acids 771-784 of Human Rabenosyn 5. Entr...
... ( Abpromise for all tested ... Synthetic peptide derived from residues 231 ... (Note: the amino acid sequence is ... Entrez Gene ID: 80829 ...
Anti-Salmonid Ig (H), Alk Phos, (Clone IPA5F12) (mouse IgG2a)...
Biology Products: