Navigation Links
Harvard Stem Cell researchers create cells that line blood vessels
Date:8/22/2013

In a scientific first, Harvard Stem Cell Institute scientists have successfully grown the cells that line the blood vesselscalled vascular endothelial cellsfrom human induced pluripotent stem cells (iPSCs), revealing new details about how these cells function. Using a unique approach, the researchers induced the differentiation of specific cell types by generating mechanical forces on the surface of the iPSC-derived endothelium mimicking the flow of blood. For example, cells that felt a stronger "flow" became artery cells, while those that felt a weaker "flow" became vein cells.

"It was especially exciting to us to discover that these cells are basically responding to biomechanical cues," research leader Guillermo Garca-Cardena, PhD, an HSCI Affiliated Faculty member, said. "By exposing cells to 'atheroprone flow,' we can direct differentiation of these cells into cells that are present in areas of the circulatory system that we know are affected by diseases like atherosclerosis." Garca-Cardena is now working on modeling the formation of arterial plaques using human iPSC-derived vascular endothelial cells and identifying potential drugs that might prevent plaque formation.

Garca-Cardena's team, which included Harvard School of Engineering and Applied Sciences graduate student William Adams, found that the iPS-derived human endothelial cells display three critical functions carried out by mature endothelium in the body: mounting inflammatory responses, keeping blood from leaking out of the blood vessel, and preventing blood clots.

Based on this information, Garca-Cardena's work, published this month in the journal Stem Cell Reports, has another exciting implicationit could potentially reduce, or even eliminate the need for heparin use during kidney dialysis and lung failure treatmentmaking both markedly safer.

Traditionally, patients undergoing dialysis are treated with heparin, a powerful drug, which prevents the blood from clotting as it's routed through the dialysis machine. While heparin is quite effective in preventing clotting, because it considerably thins the blood, it can also cause loss of blood, internal bleeding, and interfere with the healing process.

"The iPSC-derived endothelial cells cells beautifully function as an anticoagulant surface," said Garca-Cardena, an Associate Professor of Pathology at Harvard Medical School and Brigham and Women's Hospital. "In the future, we may take a tissue sample from a patient, generate iPSCs, and then cover an extracorporeal device with the patient's own endothelial cellsso the patient can go home with the device without the need for regular heparin shots."


'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert

Related biology news :

1. Harvard and USC scientists show how DHA resolves inflammation
2. Harvards Wyss Institute and Sony DADC announce collaboration on Organs-on-Chips
3. Renewed Harvard-BASF initiative to advance functional materials
4. Got to go? Harvard scientists figure out how you know
5. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
6. Researchers figure out why gold nanoparticles can penetrate cell walls
7. Finnish researchers develop quick test kit for detecting phenolic compounds in drinking water
8. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
9. UC Davis researchers discover molecular target for the bacterial infection brucellosis
10. Researchers report a critical role for the complement system in early macular degeneration
11. Researchers study seleniums effects on horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... BOUNTIFUL, Utah (PRWEB) , ... May 24, 2017 ... ... announces the selection and implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient Recovery ... a key component of a $24 million plant upgrade to sustainably meet current ...
(Date:5/24/2017)... , May 23, 2017 As Ebola resurfaces ... with four deaths and 20 suspected cases now reported, a ... the PubMed database, showed a correlation between the 2014 and ... Replikin counts rose sharply in 2012-13, which preceded the 2014 ... in the Ebola gene Replikin counts in 2014-15, which again ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... month its 20th anniversary, marking the occasion with a strong presence at Bio-IT ... Welcome Reception and further extends an invitation to all attendees to view ...
(Date:5/23/2017)... ... May 23, 2017 , ... Energetiq Technology, ... announced a facility expansion to accommodate its rapid growth. , The renovations at ... and renovation of the existing areas. The expansion includes, a state-of-the-art engineering facility, ...
Breaking Biology Technology: