Navigation Links
Harnessing the power of stem cells to unlock the secrets of motor neuron disease
Date:5/23/2010

urons. As a result, we will be able to home in on the pivotal biochemical pathways that are altered in motor neuron disease, opening up promising new treatment strategies."

The research

The principal aim of the Association's 800,000 three-year programme is to develop and characterise human brain cells, derived from the skin cells of MND patients with the hereditary TDP-43 form of the disease and also from 'control' donors who do not have MND and carry the normal TDP-43 gene.

The TDP-43 gene appears to be a direct cause of MND in around 1% of cases but the protein that the gene produces is found in up to 90% of MND cases. This discovery has been described as 'a seismic shift' in understanding the disease, as it points to TDP-43 playing a pivotal role in many forms of MND. The TDP-43 protein has also been implicated in other conditions - in particular some forms of dementia - so it may prove to play a contributory role in a wider number of neurodegenerative diseases. (For further information on TDP-43 and its role in this programme please see the background briefing paper.)

The skin cells are initially 'reprogrammed' to generate induced pluripotent stem cells (iPS cells) which are very similar to stem cells derived from human embryos. The iPS cells can then be induced to turn into either of the two main cell types known to be involved in the disease: the motor neurons which degenerate in MND; and other vital support cells called astrocytes.

Although it is the motor neurons that die in MND, it is known that the disease is not solely restricted to these cells. The support cells that normally play a role in nurturing motor neurons can inadvertently cause damage, and it is through this mechanism that scientists believe that the disease spreads from one part of the brain and spine to the next.

The MND Association's programme will address a fundamental question of whether the support cells from healthy or TDP
'/>"/>

Contact: Louise Coxon
louise.coxon@mndassociation.org
44-776-076-5142
University of Edinburgh
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Harnessing cloud computing for data-intensive research on oceans, galaxies
2. Protein power for Jack and the beanstalk
3. New book from the AGA empowers celiac disease patients to get healthy
4. ONR scientist generates mud power for NPR radio audience
5. Purple Pokeberries hold secret to affordable solar power worldwide
6. Georgia Powers Green Energy Program Redesigned to Include More Solar Power
7. Fish oil supplements provide no benefit to brain power
8. Powerful new method allows scientists to probe gene activation
9. SuperPower and UH sign high temperature superconducting wire license agreements
10. Researchers harness the power of plants to fight hemophilia
11. First whole genome sequencing of family of 4 reveals new genetic power
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... store four times more carbon than the atmosphere ... have a big effect on atmospheric greenhouse gas ... Nature Climate Change concludes that climate warming ... affect soil carbon storage, despite increases in ecosystem ... Forest Service Research Ecologist Dr. Christian Giardina, with ...
(Date:9/23/2014)... Scientists often measure the effects of temperature on insects ... and abundance, but a Dartmouth study shows for the ... addition to temperature, ultimately limits how fast they grow. ... more about the overall environmental conditions that shape the ... lead author Lauren Culler , an Arctic postdoctoral ...
(Date:9/23/2014)... today that the Company has secured $21 million in ... used to expand the Company,s cancer immunotherapy pipeline and ... Yuan Capital led the round, with participation from Majuven ... Suma Venture and Harbinger Venture Capital. , Eureka ... antibodies engineered to mimic the functions of a T ...
Breaking Biology News(10 mins):Study helps assess impact of temperature on belowground soil decomposition 2Insects' fear limits boost from climate change, Dartmouth study shows 2
... in the Journal of Proteome Research, authored by ... GmbH, Rosetta Inpharmatics LLC, CXR Biosciences Ltd, the ... synergisms and enhanced analytic power of the combination ... proprietary microarray analysis methods of Genomatix Software GmbH., ...
... The Ohio State University have demonstrated that Target Region ... preserving the important genetic diversity of ornamental flower collections. ... the most popular flowers the world. So popular, in ... 3,000 varieties of geranium in their 2004 distribution catalogue. ...
... common dietary molecules found in legumes and bran ... radiation, researchers from the University of Maryland report. ... skin cells and a skin cancer-prone mouse from ... radiation found in sunlight, the team reported today ...
Cached Biology News:'TRAP' preserves genetic properties of popular geranium 2Antioxidants could provide all-purpose radiation protection 2Antioxidants could provide all-purpose radiation protection 3
(Date:9/23/2014)... Calif. , Sept. 23, 2014 ... in India devoted to genome-based research ... Biomedical Genomics (NIBMG) is taking a bite out of ... cancer among males in India with ... storage solutions from DataDirect Networks (DDN). , To fuel ...
(Date:9/23/2014)... --  GenoSpace , a precision medicine software company that ... the broad use of genomic data in research and ... Phase I of a Fast Track Small Business Innovation ... (NIH) to enable enhanced data access and cohort construction ... During the past decade, the cost ...
(Date:9/23/2014)... September 23, 2014 Dr. Williams says, ... book on healthcare offers a three phase process that ... healthcare delivery system that would go far beyond anything ... regarding the delivery of healthcare.” , “Every effort to ... failed to provide discernable progress throughout that system because ...
(Date:9/22/2014)... 22, 2014 Patients who were treated with a statin ... were significantly more likely to survive than those who ... JAMA Neurology . This study was conducted by ... of cholesterol-lowering statins can improve survival in victims of ... or obstruction of a blood vessel that blocks blood ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5GenoSpace Awarded Fast Track SBIR Grant to Enable Data Access and Cohort Construction for Biorepositories 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2
... SAN FRANCISCO, Calif., Aug. 23 Monogram,Biosciences, Inc. (Nasdaq: ... CEO,and Chairman, is scheduled to present a corporate overview ... September 5, 2007,at 3:15 p.m. (Eastern Time) at the ... live audio broadcast or the subsequent archived,recording, log on ...
... (Nasdaq: KNDL ), a,leading, global full-service clinical ... 10th anniversary as a public company by,ringing the ... also marked the,anniversary with an Investor Day at ... and shareholders the company,s perspective on the,latest industry ...
... Initiative to Pursue Cures for Patients, ... controversial Human Cloning, WASHINGTON, Aug. 22 Today, a ... taxpayer funds,support cures for patients, without involving human cloning. ... statement on the new initiative, Cures Without Cloning. "I ...
Cached Biology Technology:Monogram Biosciences to Present at the Thomas Weisel Partners Healthcare Conference 2007 2Kendle Marks 10th Anniversary as Public Company With NASDAQ Opening Bell Ceremony and Investor Day Event 2Kendle Marks 10th Anniversary as Public Company With NASDAQ Opening Bell Ceremony and Investor Day Event 3Kendle Marks 10th Anniversary as Public Company With NASDAQ Opening Bell Ceremony and Investor Day Event 4Kendle Marks 10th Anniversary as Public Company With NASDAQ Opening Bell Ceremony and Investor Day Event 5
... clone d1-174 GenBank Accession Number : ... N-terminal tagged fusion protein corresponding to full ... Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium ... 30% Quality Assurance: routinely evaluated by immunoblot ...
Rat CXCL7/Thymus Chemokine-1 DuoSet Economy Pack, 45 Plate...
Recombinant Rat Fas Ligand/TNFSF6...
FGF Receptor 1 Antibody...
Biology Products: