Navigation Links
Harnessing anticancer drugs for the future fight against influenza
Date:9/5/2012

Medical Systems Virology group at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki, together with its national and international collaborators, developed a new cell screening method that can be used to identify potential anti-influenza drugs. The researchers were able to identify two novel compounds with anti-influenza activity, obatoclax and gemcitabine and prove the efficacy of a previously known drug saliphenylhalamide.

The study was recently accepted for publication in the Journal of Biological Chemistry and is now available online.

Influenza viruses cause significant human morbidity and mortality. To treat the infections, different virus-directed drugs have been developed. However, the currently available drugs are targeting viral proteins and due to a high mutation rate the influenza viruses quickly develop resistance to them. For that reason, next-generation antiviral drugs should be directed towards the host functions. The results of this study provide a foundation for development of next-generation antiviral drugs. Furthermore, these identified compounds can be used as chemical tools when studying the molecular mechanisms of virus-host interactions.

"An interesting aspect of this study is that the antiviral effects of obatoclax, saliphenylhalamide and gemcitabine, which all are either investigational or approved anticancer agents, are achieved at much lower concentrations than that needed to mediate cancer cell death" said the group leader Denis Kainov.

However, further research is still needed before these drugs can be clinically tested and applied in influenza infections.

This research project is a good example of repurposing of drugs, i.e. finding new applications for existing drugs and thus saving money and time on drug development.

"We anticipate that these types of drugs could in the future reinforce the therapeutic arsenal and address the needs of the society to control influenza outbreaks", said Olli Kallioniemi, the Director of FIMM.


'/>"/>
Contact: Dr. Laura Kakkola
laura.kakkola@fimm.fi
358-503-112-552
University of Helsinki
Source:Eurekalert  

Related biology news :

1. Harnessing the Materials Genome Conference
2. A new vision for harnessing data about life on Earth
3. High levels of TRAIL protein in breast milk might contribute to anticancer activity
4. Chemicals today, drugs tomorrow: U-Ms new Center for Drug Discovery
5. Target for potent first-strike influenza drugs identified
6. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
7. Single protein promotes resistance to widely used anti-estrogen drugs
8. Efforts to develop new drugs that hopefully will never be used
9. Arsenic for better drugs and cleaner crops
10. MIT-designed cooler preserves tuberculosis drugs, records doses
11. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harnessing anticancer drugs for the future fight against influenza
(Date:12/6/2016)... DALLAS , Dec. 6, 2016 ... criminal justice technology solutions for public safety, investigation, ... (PEP) jointly announced today a five (5) year ... exclusive agreement to expand the rehabilitation and reentry ... PEP History Established in 2004, the Prison ...
(Date:11/30/2016)... , Nov. 30, 2016 Not many of us realize that we ... of recovery so we need to do it well. Inadequate sleep levels have been ... blood pressure, stroke, diabetes, and even cancer. Maybe now is the best ... that could help them to manage their sleep quality? ... ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... ... December 09, 2016 , ... DuPont Industrial Biosciences ... the Breakthrough Solution of the Year Award from Platts Global Energy for ... The award was announced at the 18th Platts Global Energy Awards, held in ...
(Date:12/9/2016)... ALBANY, New York , December 9, 2016 /PRNewswire/ ... Research states that the top five players in the  ... of 62.7% in the overall market in 2015. Players ... and Perkin Elmer have remained dominant in the global ... persistent efforts to ensure product innovation. Product upgrades and ...
(Date:12/9/2016)... Dec. 9, 2016 China Cord Blood Corporation (NYSE: ... China,s leading provider of cord blood collection, laboratory ... today announced the results of its 2016 Annual General Meeting, ... S.A.R., China . At ... the re-appointment of KPMG Huazhen LLP as the independent auditors ...
(Date:12/9/2016)... India , December 9, 2016 According ... & Services (Primer, Probe, Custom, Predesigned, Reagent Equipment), Application (Research, PCR, ... Forecasts to 2021" published by MarketsandMarkets, the global market is expected ... in 2016, at a CAGR of 10.6% during the forecast period. ... ...
Breaking Biology Technology: