Navigation Links
Harm reduction cigarettes can be more harmful than conventional brands, researchers report
Date:10/20/2010

RIVERSIDE, Calif. To reduce the toxicity of cigarette smoke, tobacco companies have introduced "harm reduction cigarettes," often marketed as safer than conventional brands.

But stem cell scientists at the University of California, Riverside have found that even sidestream smoke (which burns off the tip of a cigarette) from harm reduction cigarettes impairs growth of human embryonic stem cells more than sidestream smoke from a conventional brand.

"Harm reduction products are not necessarily safer than their conventional counterparts," said Prue Talbot, the director of UC Riverside's Stem Cell Center and the research team leader. "Our analyses show there is significant toxicity in harm reduction products, and our data show that reduction of carcinogens in harm reduction mainstream smoke does not necessarily reduce the toxicity of unfiltered sidestream smoke."

Because it is not possible to directly determine chemical toxicity on actual human embryos, the researchers developed tests with human embryonic stem cells, which model young embryos, to measure and compare the toxicity of mainstream (smoke actively inhaled by smokers) and sidestream smoke from both conventional and harm reduction cigarette brands.

"Embryonic stem cells provide the best model currently available for evaluating the effects of environmental toxicants on prenatal stages of development, which are usually the most sensitive to chemical stress," said Talbot, a professor of cell biology and neuroscience.

Her group also found that sidestream smoke was consistently more potent to the embryonic stem cells than mainstream smoke, regardless of whether the cigarette brand was harm reduction or conventional.

"This information should be valuable to potential users of harm reduction cigarettes and should be taken into account when establishing policies regarding the sale, advertising, and use of harm reduction products," Talbot said.

Study results appear in the November issue of Toxicological Sciences.

For the analyses, the researchers used a rapid human embryonic stem cell-based test that provides data on dynamic cellular processes by combining time-lapse video data with video bioinformatics tools.

Talbot's research team examined the following harm-reduction cigarette brands: Marlboro Lights, Advance Premium Lights, and Quest. The team used Marlboro Red cigarettes to represent conventional brands.

Tobacco smoke is comprised of both mainstream smoke and sidestream smoke. The latter is the major component of secondhand smoke, also called environmental tobacco smoke, and is inhaled by passive smokers.

Harm reduction cigarettes are made using complex filters or by genetically altering tobacco plants to reduce nicotine concentration.


'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California -- Riverside
Source:Eurekalert  

Related biology news :

1. Organic soils continue to acidify despite reduction in acidic deposition
2. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
3. Reduction in parasite infections ahead for India
4. Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths
5. A reductionist approach to HIV research
6. Improved near-real-time tracking of 2010 El Niño reveals marine life reductions
7. Fires in Amazon challenge emission reduction program
8. CO2 reduction policies in Spain strengthen the services sector
9. Improving crisis prediction, disaster control and damage reduction
10. Optimizing climate change reduction
11. Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harm reduction cigarettes can be more harmful than conventional brands, researchers report
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
(Date:1/13/2016)... New York , January 13, 2016 ... Market Research has published a new market report titled ... Growth, Trends, and Forecast, 2015 - 2023. According to the ... in 2014 and is anticipated to reach US$1,625.8 mn ... 2015 to 2023. In terms of volume, the biometric ...
(Date:1/11/2016)... , Jan. 11, 2016  higi, the leading ... 10,000 retail locations, web and mobile, today announced ... million from existing investors. --> ... devoted to further innovate higi,s health platform – ... web portal – including expanding services and programs ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... EDISON, N.J. , Feb. 4, 2016 ... company focused on the development and commercialization of targeted ... BIO CEO & Investor Conference 2016, to be held ... and Source Capital Group,s 2016 Disruptive Growth & Healthcare ... on February 10-11, 2016. James Sapirstein ...
(Date:2/4/2016)... , February 4, 2016 ... Laboratories (ABL), Inc. --> Strasbourg, France ... --> PharmaVentures is pleased to announce that it ... its biopharmaceutical manufacturing unit in Strasbourg, France ... --> --> Transgene (Euronext: ...
(Date:2/3/2016)... -- With the growing need for better therapeutics, and ... such as monoclonal antibodies, recombinant protein therapeutics and ... are in high demand. Conventionally expression systems were ... of these therapeutics. However, due to issues with ... approaches and novel expression systems are currently being ...
(Date:2/3/2016)... ... February 03, 2016 , ... ... a new office dedicated to the North American healthcare market. , Aerocom Healthcare, ... healthcare facilities. The company will provide new pneumatic tube systems or expand ...
Breaking Biology Technology: