Navigation Links
HapMap browsing and DDDP methods for genetic analysis featured in CSH Protocols
Date:7/2/2008

COLD SPRING HARBOR, N.Y. (Tuesday, July 1, 2008) To aid in the study of genetic diseases, scientists with the International Haplotype Map Project have developed a haplotype map of the human genome, a tool that displays common patterns of genetic variation. While data from the project are available for unrestricted public use from the project's website (www.hapmap.org), the new tools needed to browse the map can be difficult to master for the beginner. This month's issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc7_08.dtl) features a set of articles with clear, step-by-step instructions for the analysis of HapMap data.

"Browsing HapMap Data Using the Genome Browser" provides details on how to navigate to and explore HapMap data for a gene or region of interest. Written by Albert Vernon Smith, this protocol shows how to analyze a candidate gene to find out whether there are any common single nucleotide polymorphisms (SNPs) in the immediate vicinity, what those SNPs' alleles are, and the relative frequencies of the alleles in the population. The protocol is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/8/pdb.prot5023).

The second featured method for July, "In Vitro Screening for Regulated Transcription Factors with Differential Display of DNA-Binding Proteins (DDDP)," provides a method for identifying proteins that are actively binding DNA and playing a role in gene regulation. Developed in the laboratory of Ueli Schibler (http://www.molbio.unige.ch/schibler/index.php), this method provides a new level of sensitivity to complement standard genomic screening and proteomic methods for finding transcription factors. This method is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/8/pdb.prot5028).


'/>"/>

Contact: David Crotty
crotty@cshl.edu
516-422-4007
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
2. Contraception: progress brings hope for new methods for men
3. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
4. New book presents methods to poke and prod individual molecules
5. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
6. Powerful yet reliable proteomics techniques are the focus of a new methods book
7. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
8. Expanded histology methods book covers processing of animal, plant, and microbial tissues
9. Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
10. Does the desire to consume alcohol and tobacco come from our genetic makeup?
11. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... During a two ... into a viable company, CereScan’s CEO, John Kelley, joined other Denver business leaders ... and mentor in the Denver area business community, shared his top fundamental learnings ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intelligent Implant Systems announced today that ... 510(k) for sale in the United States. These components expand the capabilities of ... With one-level sales beginning in October of 2015, the company has seen significant sales ...
(Date:4/28/2016)... , April 28, 2016 ... Stirling, and Brayton Cryocoolers), Service (Technical Support, Product Repairs ... Geography - Global Forecast to 2022", published by MarketsandMarkets, ... 2.94 Billion by 2022, at a CAGR of 7.29% ... market data Tables and 94 Figures spread through 159 ...
(Date:4/28/2016)... Conn. (PRWEB) , ... April 28, 2016 , ... ... financing and ongoing support for Connecticut's innovative, growing companies, today announced the launch ... health and financial technology (fintech) companies. , “VentureClash looks to attract ...
Breaking Biology Technology: