Navigation Links
HapMap browsing and DDDP methods for genetic analysis featured in CSH Protocols
Date:7/2/2008

COLD SPRING HARBOR, N.Y. (Tuesday, July 1, 2008) To aid in the study of genetic diseases, scientists with the International Haplotype Map Project have developed a haplotype map of the human genome, a tool that displays common patterns of genetic variation. While data from the project are available for unrestricted public use from the project's website (www.hapmap.org), the new tools needed to browse the map can be difficult to master for the beginner. This month's issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc7_08.dtl) features a set of articles with clear, step-by-step instructions for the analysis of HapMap data.

"Browsing HapMap Data Using the Genome Browser" provides details on how to navigate to and explore HapMap data for a gene or region of interest. Written by Albert Vernon Smith, this protocol shows how to analyze a candidate gene to find out whether there are any common single nucleotide polymorphisms (SNPs) in the immediate vicinity, what those SNPs' alleles are, and the relative frequencies of the alleles in the population. The protocol is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/8/pdb.prot5023).

The second featured method for July, "In Vitro Screening for Regulated Transcription Factors with Differential Display of DNA-Binding Proteins (DDDP)," provides a method for identifying proteins that are actively binding DNA and playing a role in gene regulation. Developed in the laboratory of Ueli Schibler (http://www.molbio.unige.ch/schibler/index.php), this method provides a new level of sensitivity to complement standard genomic screening and proteomic methods for finding transcription factors. This method is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/8/pdb.prot5028).


'/>"/>

Contact: David Crotty
crotty@cshl.edu
516-422-4007
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
2. Contraception: progress brings hope for new methods for men
3. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
4. New book presents methods to poke and prod individual molecules
5. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
6. Powerful yet reliable proteomics techniques are the focus of a new methods book
7. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
8. Expanded histology methods book covers processing of animal, plant, and microbial tissues
9. Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
10. Does the desire to consume alcohol and tobacco come from our genetic makeup?
11. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
Breaking Biology Technology: