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HWI scientist first in world to unravel structure of key breast cancer target enzyme
Date:1/7/2009

drogens to estrogens. He also will be working with collaborators to develop medicinal complexes for testing. In collaboration with organic synthetic chemist Dr. Huw Davies of Emory University and RPCI colleagues, they will conduct cellular and animal studies of those complexes.

What Was The Project History?

The aromatase and sulfatase projects were started at HWI by Dr. Yoshio Osawa more than 30 years ago. His preliminary work laid the foundation for the eventual solution of the structure of estrone sulfatase. A number of collaborators played a role in the 17beta-hydroxysteroid dehydrogenase project's early work including scientists in Canada, Finland and HWI Hauptman Distinguished Scientist Dr. William Duax. Ghosh and Osawa started to collaborate in 1995. When Osawa retired in 1998, Ghosh took the project over and developed a revolutionary method of purifying and crystallizing these enzymes. "Everyone had given up on crystallizing the enzyme," Ghosh said. "Using a 'secret recipe,' we have been able to crystallize it and identify the structure knowledge which will be used to make much better drugs."

The 9th International Aromatase Meeting held in Shanghai China in October 2008 was the venue for the first formal presentation of ground-breaking breast cancer research conducted by HWI's Dr. Debashis Ghosh. A biennial meeting, the conference draws scientists from all over the world who are interested in the role aromatase plays in various cancers and other diseases.


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Contact: Tara A. Ellis
tellis@hwi.buffalo.edu
716-898-8596
Hauptman-Woodward Medical Research Institute
Source:Eurekalert  

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