Navigation Links
HWI scientist first in world to unravel structure of key breast cancer target enzyme
Date:1/7/2009

drogens to estrogens. He also will be working with collaborators to develop medicinal complexes for testing. In collaboration with organic synthetic chemist Dr. Huw Davies of Emory University and RPCI colleagues, they will conduct cellular and animal studies of those complexes.

What Was The Project History?

The aromatase and sulfatase projects were started at HWI by Dr. Yoshio Osawa more than 30 years ago. His preliminary work laid the foundation for the eventual solution of the structure of estrone sulfatase. A number of collaborators played a role in the 17beta-hydroxysteroid dehydrogenase project's early work including scientists in Canada, Finland and HWI Hauptman Distinguished Scientist Dr. William Duax. Ghosh and Osawa started to collaborate in 1995. When Osawa retired in 1998, Ghosh took the project over and developed a revolutionary method of purifying and crystallizing these enzymes. "Everyone had given up on crystallizing the enzyme," Ghosh said. "Using a 'secret recipe,' we have been able to crystallize it and identify the structure knowledge which will be used to make much better drugs."

The 9th International Aromatase Meeting held in Shanghai China in October 2008 was the venue for the first formal presentation of ground-breaking breast cancer research conducted by HWI's Dr. Debashis Ghosh. A biennial meeting, the conference draws scientists from all over the world who are interested in the role aromatase plays in various cancers and other diseases.


'/>"/>

Contact: Tara A. Ellis
tellis@hwi.buffalo.edu
716-898-8596
Hauptman-Woodward Medical Research Institute
Source:Eurekalert  

3

GOOD

Page: 1 2 3

Related biology news :

1. Florida professor creates endowment for insect scientists
2. NYU scientists discover dangerous new method for bacterial toxin transfer
3. Scientists can now differentiate between healthy cells and cancer cells
4. Scientists make strides toward defining genetic signature of Alzheimers disease
5. Johns Hopkins scientists pull proteins tail to curtail cancer
6. Trees wont stop tsunamis, scientists warn
7. UCSB scientists show how certain vegetables combat cancer
8. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
9. Haag honored with Presidential Early Career Scientists Award
10. UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology
11. Scientists study how asbestos fibers trigger cancer in human cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
HWI scientist first in world to unravel structure of key breast cancer target enzyme
(Date:5/17/2013)... of a group of proteins in the brain responsible ... new target that could increase cell survival. , The ... Biochemistry and published in the EMBO journal ... to new therapies for stroke and other brain diseases. ... team which identified a protein, known as SUMO, responsible ...
(Date:5/17/2013)... Sustainable Global Logistics Operations) is aiming to cut CO2 ... intermodal loading systems and the boosting of intelligent systems ... with experience in the logistics sector and in supply ... a duration of three and a half years. , ... components and ontologies shared by the users, objects and ...
(Date:5/17/2013)... of American Societies for Experimental Biology (FASEB) released a ... (NIH) funding trends highlighting the devastating impact of sequestration ... FASEB analysis follows a May 15th Senate Appropriations Committee ... testified that the $1.6 billion cut the agency sustained ... substantial impact on the scientific community." , According ...
Breaking Biology News(10 mins):SUMO wrestling cells reveal new protective mechanism target for stroke 2New logistics services that will cut energy consumption and CO2 emissions 2
... Plant leaves and surfaces are teeming with microbial life, ... immune systems to fend off any intruding microorganisms they ... the online open access journal, BMC Biology shows how ... authors Dalial Freitak, David Heckel and Heiko Vogel from ...
... University and the National Center for Ecological Analysis and ... to predict gene flow across landscapes. Their approach could ... spots for wildlife corridors, which are crucial to protecting ... circuit theory and ecological connectivity, said Brad McRae, head ...
... started out as obscure inventions but are now indispensable for ... with modern society look like" The answer may lie in ... University of Calgary biologist who is trying to figure out ... Unlike most creatures, geckos dont use sticky secretions to help ...
Cached Biology News:Insect gut detects unhealthy meal 2Model connects circuit theory to wildlife corridors 2Sticky questions tackled in gecko research 2
(Date:5/20/2013)...  Dr. Gerald Zon , noted ... launched a new blog in conjunction with TriLink BioTechnologies. ... focuses on what,s trending in the field of nucleic ... discussions of research presented at conferences and meetings, reviews ... Zon (PhD Princeton University 1971) developed automated synthesis of ...
(Date:5/20/2013)... ROCKVILLE , Md. and BALTIMORE ... Inc. (BHI), a regional private-public partnership focusing ... to early-stage funding in Central Maryland ... Aiyar, Ph.D., M.B.A., as the first Entrepreneur-in-Residence (EIR) ... (NIH) National Heart, Lung and Blood Institute ...
(Date:5/20/2013)... -- Rhythm announced today the results of a second ... ghrelin agonist for the treatment of diabetic gastroparesis in ... significantly accelerates early gastric emptying and reduces upper gastrointestinal ... gastroparesis. The findings were presented at the Digestive Disease ... and recently published in Clinical Gastroenterology and Hepatology. ...
(Date:5/20/2013)... 20, 2013 Recognizing exciting and ... members to its 2013 Class of Young Professors. ... will provide this outstanding international group with more ... basic science to meet global challenges.     , The ... promising young and untenured research faculty working in ...
Breaking Biology Technology:Dr. Gerald 'Jerry' Zon Launches New Blog for TriLink BioTechnologies 2BioHealth Innovation, Inc. Names Ram Aiyar as Entrepreneur-in-Residence to NIH National Heart, Lung and Blood Institute 2BioHealth Innovation, Inc. Names Ram Aiyar as Entrepreneur-in-Residence to NIH National Heart, Lung and Blood Institute 3BioHealth Innovation, Inc. Names Ram Aiyar as Entrepreneur-in-Residence to NIH National Heart, Lung and Blood Institute 4Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Gastroparesis in Patients with Type 1 Diabetes 2Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Gastroparesis in Patients with Type 1 Diabetes 3DuPont Celebrates Scientific Innovation by Recognizing Young Professors 2DuPont Celebrates Scientific Innovation by Recognizing Young Professors 3
... Calif.) Smaller. Faster. More efficient. These are the ... nanoscale structures that will help to speed up computers. ... have made a major contribution to this field by ... computers smaller, faster, and more efficient. The new process ...
... VANCOUVER, Sept. 25 /PRNewswire-FirstCall/ - Dragon Pharmaceutical Inc.,("Dragon ... BBSE: DRP), a,leading international pharmaceutical company, today announced ... Garry Wong, Chief Financial,Officer will present at 9:30 ... Quebec 2008 at the Chateau Frontenac hotel in ...
... U.S. Senate to Take Similar Action, WASHINGTON, ... (ATA), the industry trade organization for the,leading U.S. ... taking action that if adopted by the Senate, ... (DHS) US-VISIT,Exit program., The House-approved language would ...
Cached Biology Technology:New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 2New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 3New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 4New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 5
...
...
...
... in the submicron range are part of ... and control of particle size is important ... can reliably detect the component populations in ... Particle Size Analyzer uses Photon Correlation Spectroscopy ...
Biology Products: