Aromatase is the only enzyme in the vertebrate world that makes estrogens from androgens. All estrogens in the human body are made by aromatase. Drugs, such as Tamoxifen, that prevent aromatase from making estrogens constitute one of the foremost therapies for estrogen-dependent breast cancer. These drugs do not discriminate in what they target in the body, which results in significant side effects. Aromatase inhibitor drugs (AIs) have only been on the market a few years and are targeted to inhibit aromatase specifically. But because the structure was not known, nor the mechanism of androgen to estrogen conversion, the AIs currently in use have been developed using trial and error methods resulting in greater vulnerability to contraindications and side effects.
"Now that the Ghosh Lab has unraveled the molecular details of aromatase, drugs can be designed to specifically target aromoatase," Dr. Walter A. Pangborn, Executive Vice President at HWI, said. "This means that results from this research will form the basis for novel breast cancer drugs that are highly specific for aromatase but cause minimal side effects."
What Happens Next?
Ghosh now will work to test his hypothesis of the chemical mechanism involved in the conversion of an
|Contact: Tara A. Ellis|
Hauptman-Woodward Medical Research Institute