Navigation Links
HPV vaccine may prevent preterm births

Chronic human papilloma virus (HPV)-infections can lead to cellular changes in the cervix that can be a pre-stage to cervical cancer. Surgical treatment of these pre-stages gives an increased risk of preterm birth in subsequent pregnancies. As the HPV-vaccine can prevent pre-stages of cervical cancer, it may therefore reduce the number of preterm births. A new Norwegian study has calculated the benefits of HPV-vaccination.

Cervical cancer development is a step-wise process that begins with minor cell changes caused by HPV infection. Cellular changes can progress and become more serious. Long-term, they can cause cervical cancer if untreated. Serious cellular changes are treated by surgically removing a part of the cervix (conisation). This gynaecological procedure gives an increased risk of a woman giving birth preterm in subsequent pregnancies.

In a newly published study in Acta Obstretica et Gynecologica, Katrine D. Sjborg and Anne Eskild calculated how many preterm deliveries could be avoided by systematic HPV-vaccination. Sjborg is a consultant at stfold Hospital and Eskild is based at the Norwegian Institute of Public Health and Akershus University Hospital.

Calculations in the study are based on the following parameters:

  • proportion of pregnant women treated with conisation
  • proportion with preterm births among women who have had conisation compared those who have not had conisation
  • proportion of conisations that can be prevented by HPV-vaccination
  • proportion of fertile women who are HPV-vaccinated

Benefits of HPV-vaccination

In the study, figures from Europe and North-America are used. The results suggest that if 2 % of pregnant women are treated with conisation, between 60 and 220 preterm births per 100 000 births could be caused by surgical treatment. Nearly 60 % of these may be prevented by the HPV-vaccine, assuming that vaccination coverage is 90 %. This would mean that 35-128 preterm births per 100 000 births could be avoided. If 4 % of pregnant women are treated with conisation, 70 to 257 preterm births per 100 000 births could be avoided.

The study was not intended to state an exact figure of how many preterm births could be prevented by HPV-vaccination, but to illustrate potential benefits in this field.

Up to 10 % of all births in Scandinavia are preterm births. Only a small number of these are linked with conisation. Preterm birth can cause serious conditions in the child. Every case that can be prevented could save suffering for each child and their family. Nevertheless, there is a proven link between conisation and shorter pregnancy duration. HPV-vaccination can therefore have an important effect on prevention of extremely preterm births.


Contact: Julie Johansen
Norwegian Institute of Public Health

Related biology news :

1. Possible hepatitis C vaccine
2. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
3. New nanoparticle vaccine is more effective but less expensive
4. Flu vaccine in painless skin patches under development at Emory, Georgia Tech with NIH grants
5. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
6. An Alzheimers vaccine?
7. Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine
8. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
9. HIV isolate from Kenya provides clues for vaccine design
10. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
11. Vaccine for Ebola virus
Post Your Comments:
(Date:10/29/2015)... 29, 2015 Today, LifeBEAM , ... with 2XU, a global leader in technical performance ... hat with advanced bio-sensing technology. The hat will ... monitor key biometrics to improve overall training performance. ... two companies will bring together the most advanced technology, ...
(Date:10/26/2015)... India , October 26, 2015 ... --> adds ... 2015 to 2021 as well as ... 2015-2019 research reports to its collection ... . --> ...
(Date:10/23/2015)... GOLETA, California , October 23, 2015 ... Instruments (SMI) announce a mobile plug and play integration ... interactive real-world tasks SensoMotoric Instruments (SMI) ... established wearable solutions for eye tracking and physiological data ... with SMI Eye Tracking Glasses 2w and ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Studies reveal the differences in ... pave the way for more effective treatment for one of ...   --> --> Gum ... in cats, yet relatively little was understood about the bacteria ... been conducted by researchers from the WALTHAM Centre for Pet ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/25/2015)... Oregon , November 25, 2015 ... Market Research Report is a professional and in-depth ... industry.      (Logo: ) ... overview of the industry including definitions, classifications, applications ... is provided for the international markets including development ...
(Date:11/24/2015)... ... , ... The United States Golf Association (USGA) today announced Dr. Bruce Clarke, ... annually since 1961, the USGA Green Section Award recognizes an individual’s distinguished service to ... Clarke, of Iselin, N.J., is an extension specialist of turfgrass pathology in the department ...
Breaking Biology Technology: